Drug-Induced Erythema Multiforme

Abstract

Erythema multiforme (EM) is an acute inflammatory, mucocutaneous, psychosomatic, and vesiculobullous condition that varies from minor to major forms. The acral distribution of target lesions is a characteristic of this condition. The aetiology of erythema multiforme is multifactorial. 90% of the cases are triggered by a herpes infection, whereas 10% occur secondary to drug intake. The offending drugs include nonsteroidal anti-inflammatory drugs, antibiotics, and anticonvulsants. The present case series discusses four cases of drug-induced erythema multiforme and their management.

Ibuprofen-Induced Pancytopenia and Erythema Multiforme in an Elderly Female Patient

“…The search for the underlying etiology can be challenging. Common pharmacological causes of EM include NSAIDS, antibiotics, and anticonvulsants [9]. Further laboratory investigations may be necessary, i.e., HSV testing, autoimmune workup, and other serological tests.…”