Drug-Induced Pemphigus

Golberg, Olga; Harman, K. E.

doi:10.1007/978-3-662-45139-7_72

Cited by 53 publications

(4 citation statements)

References 7 publications

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“…Drug-related triggers may contribute in some cases because both DM and AIBD have been associated with medication exposure (Table 5; Delbaldo et al., 2002, Gaffney et al., 2018, Golberg and Harman, 2015, Seidler and Gottlieb, 2008, Stavropoulos et al., 2014, Vassileva, 1998). Medications may act as haptens, modify the antigenicity of structural proteins, or affect the immune tolerance against components of the adhesion structures among keratinocytes or at the dermoepidermal junction (Delbaldo et al., 2002).…”

Section: Discussionmentioning

confidence: 99%

Dermatomyositis in patients with autoimmune blistering diseases

Patsatsi

Pearson

Werth

2019

International Journal of Women's Dermatology

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It is common for multiple autoimmune diseases to occur in the same patient. However, autoimmune blistering diseases (AIBD) do not commonly associate with dermatomyositis (DM). We performed a literature review and found 12 previous reports that may be attributed to misdiagnosis, underreporting, or true rarity of association. Herein, we present a case of pemphigus vulgaris and a case of mucous membrane pemphigoid associated with DM and review the related literature. AIBD-associated interstitial lung disease, genetic predisposition, potential environmental triggers of both AIBD and DM, drug-related triggers, and paraneoplastic processes are discussed. Dermatologists must be vigilant for a second autoimmune disease in patients with AIBD that may have therapeutic implications.

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Section: Discussionmentioning

confidence: 99%

Dermatomyositis in patients with autoimmune blistering diseases

Patsatsi

Pearson

Werth

2019

International Journal of Women's Dermatology

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“…Known drugs include Cilazapril, fosinopril, lisinopril, nifedipine, imiquimod, carbamazepine, chloroquine/hydroxychloroquine, dipyrone, glibenclaimde, ingenol mebutate, acetazolamide, candesartan, ciprofloxacin, cocaine, diazinon, hydrochlorothiazide, irbesartan, methylisothiazolinone, metoprolol, phenytoin ( 11 , 20 , 27 – 29 , 32 – 41 , 44 , 45 ). These groups (sulfur and amides) are postulated to induce PV via immunological mechanisms that stimulate keratinocytes to produce proinflammatory cytokines such as TNF and IL-1 ( 8 , 55 – 57 ), leading to the activation of proteases and complement that contribute to acantholysis.…”

Section: Findings On Environmental and Lifestyle “Exposome” Factorsmentioning

confidence: 99%

“…To our knowledge, reports of PV induction following radiotherapy and immunotherapy are rarely reported in the literature. Isolated case-control studies identify an elevated risk of developing PV with previous radiotherapy (RT) and ultraviolet light ( 42 , 48 – 50 , 55 , 58 – 60 ). These studies report an accompanying malignancy, most commonly breast cancer or lymphomas, with an associated eruption of pemphigus lesions that range from 1 week to 1 year following irradiation.…”

Section: Findings On Environmental and Lifestyle “Exposome” Factorsmentioning

confidence: 99%

The multifactorial complexities of autoimmune development in Pemphigus vulgaris: Critical evaluation of the role of environmental and lifestyle “exposome” factors

et al. 2023

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Pemphigus vulgaris (PV) is a potentially life-threatening blistering disorder characterized by autoantibodies directed against cell-cell adhesion molecules that serves as an excellent model to study human autoimmune development. Numerous studies have identified specific Human Leukocyte Antigen (HLA) genes, in particular DRB1*0402 and DQB1*0503, that confer disease risk. Although HLA is required, it is not sufficient for the initiation of disease. As with all autoimmune diseases, the etio-pathogenesis of PV is complex, meaning it is multifactorial. Susceptibility is polygenic, and the search for non-HLA disease-linked genes continues. Moreover, twin studies across autoimmune conditions indicate that non-genetic environmental and lifestyle factors, which can be collectively grouped under the term “exposome”, are also major contributors to disease development. The literature presents evidence for the potential role of multiple triggers such as medications, infections, stress, diet, immunizations, and sleep to influence the etiology, pathophysiology, and prognosis of PV. However, a clear understanding of the degree to which specific factors impact PV is lacking. In this investigation, we comprehensively review the environmental elements listed above and consider the strength of evidence for these factors. The overall goals of this work are to provide greater insights into the factors that influence disease susceptibility, disease development and disease course and ultimately help to better guide clinicians and inform patients in the management of PV.

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“…These drugs include dpenicillamine, captopril, lisinopril, candesartan, penicillin, rifampicin, carbamazepine, nifedipine, ceftazidime, hydroxychloroquine, phenobarbital, etc. Other reported trigger factors are diseases such as infections, cancers and autoimmune conditions, radiotherapy, pregnancy, stress, UV-radiation, trauma and exposure to pesticides [11,16]. Besides, contact pemphigus is a term that refers to cases of pemphigus occurring after a contact with a variety of chemical substances [11].…”

Section: Pathopysiologymentioning

confidence: 99%

Untitled

2022

FARMACIA

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Pemphigus belongs to autoimmune blistering diseases and affects the skin and/or mucous membranes with a potentially fatal outcome in untreated patients. The main type is represented by pemphigus vulgaris (PV) which accounts for 70% of all cases in Europe. The diagnosis and management of PV in Romania are challenging due to lack of official treatment guidelines, the treatment being based on different protocols of each medical unit. This paper aims to adjust the diagnosis and management of PV in Romania according to the existing and accepted international guidelines. RezumatPemfigusul aparține grupului de boli buloase autoimune și afectează pielea și/sau mucoasele, putând avea o evoluție fatală în cazul pacienților netratați. Principala formă de boală este pemfigusul vulgar, care alcătuiește 70% din totalul cazurilor din Europa. Diagnosticul și managementul pemfigusului vulgar în România reprezintă o provocare din cauza lipsei unui protocol terapeutic oficial; tratamentul fiind bazat pe indicații diferite specifice fiecărei unități medicale. Scopul acestui manuscris este de a adapta diagnosticul și managementul pemfigusului vulgar în România în conformitate cu ghidurile existente și acceptate la nivel internațional.

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Drug-Induced Pemphigus

Cited by 53 publications

References 7 publications

Dermatomyositis in patients with autoimmune blistering diseases

Dermatomyositis in patients with autoimmune blistering diseases

The multifactorial complexities of autoimmune development in Pemphigus vulgaris: Critical evaluation of the role of environmental and lifestyle “exposome” factors

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