Drug-induced psychosis associated with crystalline methamphetamine

Abstract

A drug-induced psychosis resembling paranoid schizophrenia can occur with repeated or high-dose use of methamphetamine. While this generally resolves rapidly with cessation of stimulant use, some cases of protracted drug-induced psychosis in vulnerable individuals have been documented. Behavioural sensitization can also occur, and neuroleptics may prevent the recurrence of further psychosis triggered by ongoing low-dose methamphetamine use.

Treating Methamphetamine-Induced Resistant Psychosis with Clozapine

“…In many of studies, atypical antipsychotics have been prescribed in order to treat MIP, and the efficacy of such drugs as risperidone [13], olanzapine [14], quetiapine [15, 16], and aripiprazole [17] in treating it to some extent has been demonstrated. However, in the state of drug-resistant psychosis, there is no reliable evidence.…”

Treatment for amphetamine psychosis

“…Patients with schizophrenia and with amphetamine induced psychosis show significantly increased peripheral plasma levels of norepinephrine than levels in methamphetamine users who do not have psychosis and non-methamphetamine-using controls (Yui 1997, Yui 2000. In both conditions, patients appear for treatment with psychiatric manifestations that include hallucinations, delusions of reference and intense suspiciousness and paranoia in the setting of agitation and clear consciousness (Dore 2006;Srisurapanont 2003). In amphetamine psychosis, persecutory delusions are most frequent, followed by auditory and visual hallucinations.…”