Drug Interaction Between Sevelamer and Levetiracetam: The First Clinical Experience

Binding interactions with sevelamer and polystyrene sulfonate in vitro

“…Clinical studies and case reports have shown that sevelamer binds to levothyroxine, ciprofloxacin, mycophenolic acid, tacrolimus, cyclosporine, vitamin D analogues, lipid soluble vitamins like vitamins A, E, and K, folic acid, quetiapine, furosemide, and levetiracetam. 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 For polystyrene sulfonate, binding interactions have been described with lithium, quetiapine, and levothyroxine. 21 , 22 , 23 CKD patients often use many different drugs (average of eight drugs a day), and the prevalence of potential drug–drug interactions in CKD patients is high (75%–91%).…”

“…Clinical studies and case reports have shown that sevelamer binds to levothyroxine, ciprofloxacin, mycophenolic acid, tacrolimus, cyclosporine, vitamin D analogues, lipid soluble vitamins like vitamins A, E, and K, folic acid, quetiapine, furosemide, and levetiracetam 6‐21 . For polystyrene sulfonate, binding interactions have been described with lithium, quetiapine, and levothyroxine 21‐23 .…”

“…3 Because of their binding properties, resins are known to bind other drugs in the gastrointestinal tract, decreasing their bioavailability and clinical effectiveness.Clinical studies and case reports have shown that sevelamer binds to levothyroxine, ciprofloxacin, mycophenolic acid, tacrolimus, cyclosporine, vitamin D analogues, lipid soluble vitamins like vitamins A, E, and K, folic acid, quetiapine, furosemide, and levetiracetam. [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] For polystyrene sulfonate, binding interactions have been described with lithium, quetiapine, and levothyroxine. [21][22][23] CKD patients often use many different drugs (average of eight drugs a day), and the prevalence of potential drug-drug…”