Drug‐Loaded Mucoadhesive Patch with Active Delivery and Controlled Releasing Ability

Kim, Dongin; Bang, Seungmin; Park, Sukho

doi:10.1002/aisy.202100203

Cited by 15 publications

(7 citation statements)

References 50 publications

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“…The robotic pill is rotated along its longitudinal axis, producing displacement by each magnetic field turn. [46][47][48][49][50][51] The robotic pill can be guided through predetermined paths, as illustrated in Figure 4b, which shows the overlap of multiple images taken from Video S3, Supporting Information. This locomotion mechanism can be used to navigate the structure over complex and uneven routes.…”

Section: Resultsmentioning

confidence: 99%

Robotic Pill for Biomarker and Fluid Sampling in the Gastrointestinal Tract

Soto

Purcell

Özen

et al. 2022

Advanced Intelligent Systems

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Health relevant information is coded in circulating signatures or biomarkers, such as the secretome, extracellular vesicles, nucleic acids, bacteria, and other markers. [1][2][3] The collection and analysis of such signatures can serve as an early sign of disease initiation and its progression through repeated sampling. [4][5][6][7][8][9][10] Nevertheless, it remains a challenge to isolate or sample biomarkers from regions of the body with limited accessibility, such as the gastrointestinal (GI) tract, which is more than 9 meters in total length. [11,12] To gain access to these challenging locations, invasive medical procedures, such as surgery, biopsies, and colonoscopies, are required to extract information, limiting the repeatability of such measurements. [13][14][15] These techniques involve trained practitioners, expensive instruments, and specialized facilities, making them hard to expand to a large population. In contrast, minimally invasive approaches can also be used for sampling biomarkers. [16] For instance, liquid biopsy is a standard approach to obtain a snapshot of the signature pool from biofluids (blood, urine, or stool samples). [17,18] Although useful, liquid biopsy frequently provides indirect data that is averaged across the sample and not specific to a particular region of the body.Smart pills have been deployed as a method to investigate cavities inside the body. [19][20][21][22][23][24] For instance, the PillCam, an ingestible capsule with an embed camera, is commonly used to search for polyps in the GI. [25][26][27][28][29][30][31][32][33] More recently, smart pills have been applied to capture and sense biomarkers through lab-on-a-chip systems, [26][27][28] osmotic gradients, [29] and passive absorption in refs. [30][31][32] methods. The ability to isolate biomarkers within localized environments

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Section: Resultsmentioning

confidence: 99%

Robotic Pill for Biomarker and Fluid Sampling in the Gastrointestinal Tract

Soto

Purcell

Özen

et al. 2022

Advanced Intelligent Systems

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“…This comprehensive system not only provides precise and controlled deployment of drug-loaded patches to targeted gut lesions but also demonstrates the effectiveness and utility of magnetic systems in gastroretentive medical devices. 73…”

Section: Mechanisms Of Retentionmentioning

confidence: 99%

Intestinal retentive systems – recent advances and emerging approaches

Naik,

Matonis,

Balakrishnan

et al. 2024

J. Mater. Chem. B

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“…[1,21] Once approaching the target, the robot can perform diagnostic and potentially interventional procedures via various types of end-effector tools, with examples summarized in Table 1. [11,[22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] This section outlines some of the fundamental soft medical robots, i.e., endoscopes, catheters, and ingestible devices for minimally invasive procedures.…”

Section: An Overview Of Soft Medical Robotsmentioning

confidence: 99%

Integrated Sensors for Soft Medical Robotics

Qiu,

Ashok,

Nguyen

et al. 2024

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Minimally invasive procedures assisted by soft robots for surgery, diagnostics, and drug delivery have unprecedented benefits over traditional solutions from both patient and surgeon perspectives. However, the translation of such technology into commercialization remains challenging. The lack of perception abilities is one of the obstructive factors paramount for a safe, accurate and efficient robot‐assisted intervention. Integrating different types of miniature sensors onto robotic end‐effectors is a promising trend to compensate for the perceptual deficiencies in soft robots. For example, haptic feedback with force sensors helps surgeons to control the interaction force at the tool‐tissue interface, impedance sensing of tissue electrical properties can be used for tumor detection. The last decade has witnessed significant progress in the development of multimodal sensors built on the advancement in engineering, material science and scalable micromachining technologies. This review article provides a snapshot on common types of integrated sensors for soft medical robots. It covers various sensing mechanisms, examples for practical and clinical applications, standard manufacturing processes, as well as insights on emerging engineering routes for the fabrication of novel and high‐performing sensing devices.

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Drug‐Loaded Mucoadhesive Patch with Active Delivery and Controlled Releasing Ability

Cited by 15 publications

References 50 publications

Robotic Pill for Biomarker and Fluid Sampling in the Gastrointestinal Tract

Robotic Pill for Biomarker and Fluid Sampling in the Gastrointestinal Tract

Intestinal retentive systems – recent advances and emerging approaches

Integrated Sensors for Soft Medical Robotics

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