Drug-loaded polymeric nanoparticles: a review

Castro, Karine Cappuccio de; Costa, Josiel Martins; Campos, Maria Gabriela Nogueira

doi:10.1080/00914037.2020.1798436

Cited by 87 publications

(27 citation statements)

References 110 publications

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“…[ 50 , 51 ]. Finally, to achieve specificity and increase the bioconjugation and targeting of NPs, it is necessary to attach them to suitable biomolecules such as enzymes, antibodies, peptides, drugs etc., which also promotes or maintains their dispersion [ 40 , 52 , 53 , 54 ]. All of these factors are required in designing optimum nanoparticulate systems for bio-imaging applications.…”

Section: Nanoparticles In Molecular Imagingmentioning

confidence: 99%

Recent Advances in Gadolinium Based Contrast Agents for Bioimaging Applications

et al. 2021

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Gadolinium (Gd) based contrast agents (CAs) (Gd-CAs) represent one of the most advanced developments in the application of Gd for magnetic resonance imaging (MRI). Current challenges with existing CAs generated an urgent requirement to develop multimodal CAs with good biocompatibility, low toxicity, and prolonged circulation time. This review discussed the Gd-CAs used in bioimaging applications, addressing their advantages and limitations. Future research is required to establish the safety, efficacy and theragnostic capabilities of Gd-CAs. Nevertheless, these Gd-CAs offer extraordinary potential as imaging CAs and promise to benefit bioimaging applications significantly.

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Section: Nanoparticles In Molecular Imagingmentioning

confidence: 99%

Recent Advances in Gadolinium Based Contrast Agents for Bioimaging Applications

et al. 2021

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“…A review on the drug-laden polymer nanoparticle is done based on the strategies employed in modern medicine. e method was proposed by Castro et al [7], formulation capable of delivering medication in a regulated and precise manner at a given location. In this situation, stimulus-reactive nanoparticles are identified because they have lengthy circulation durations, can reach the illness site, and can optimize intracellular medicine administration.…”

Section: Related Workmentioning

confidence: 99%

Preparation of Polymeric Nanomaterials Using Emulsion Polymerization

Sahoo

Ramesh²,

Nirmala

et al. 2021

Advances in Materials Science and Engineering

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Nanoparticles are said to be active particles which are entrapped in the surface of the polymeric core. Since nanoparticles were used in medical and biotechnological fields, there is a great demand in the preparation of nanoparticles. Nanoparticles are prepared from different substances; mainly, polymer material is used in the field of preparing nanomaterials. There are different methods involved in the preparation of nanoparticles from the polymer. Various experiments and research studies were carried out on the basic preparation of nanoparticles. Emulsion polymerization could be used to make polymeric nanoparticles with a high solid concentration without the need of surfactants. To make carboxylate polystyrene beads or amidine polystyrene nanoparticles, polymeric nanocolloids containing surface functional groups were produced. In this research, the preparation of nanoparticles from emulsion polymerization is represented along with the size and distribution material.

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“…The polymeric nanoparticles (NPs) present several advantages such as versatility, due to the possibility to customize the polymers, in addition to greater bioavailability, high encapsulation capacity for hydrophilic payloads, controlled release, good dispersion in water and ability to overcome the barrier of the lipid bilayer of the cell membrane by different endocytosis pathways [10][11][12][13]. Furthermore, after parenteral administration, the NPs can easily reach the tumor tissues because of the defective and leaky structure of tumor vessels, as well as the impaired lymphatic system.…”

Section: Introductionmentioning

confidence: 99%

Overcoming MDR by Associating Doxorubicin and pH-Sensitive PLGA Nanoparticles Containing a Novel Organoselenium Compound—An In Vitro Study

et al. 2021

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In this study, we developed PLGA nanoparticles (NPs) as an effective carrier for 5′-Se-(phenyl)-3-(amino)-thymidine (ACAT-Se), an organoselenium compound, nucleoside analogue that showed promising antitumor activity in vitro. The PLGA NPs were prepared by the nanoprecipitation method and modified with a pH-responsive lysine-based surfactant (77KL). The ACAT-Se-PLGA-77KL-NPs presented nanometric size (around 120 nm), polydispersity index values <0.20 and negative zeta potential values. The nanoencapsulation of ACAT-Se increased its antioxidant (DPPH and ABTS assays) and antitumor activity in MCF-7 tumor cells. Hemolysis study indicated that ACAT-Se-PLGA-77KL-NPs are hemocompatible and that 77KL provided a pH-sensitive membranolytic behavior to the NPs. The NPs did not induce cytotoxic effects on the nontumor cell line 3T3, suggesting its selectivity for the tumor cells. Moreover, the in vitro antiproliferative activity of NPs was evaluated in association with the antitumor drug doxorubicin. This combination result in synergistic effect in sensitive (MCF-7) and resistant (NCI/ADR-RES) tumor cells, being especially able to successfully sensitize the MDR cells. The obtained results suggested that the proposed ACAT-Se-loaded NPs are a promising delivery system for cancer therapy, especially associated with doxorubicin.

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Drug-loaded polymeric nanoparticles: a review

Cited by 87 publications

References 110 publications

Recent Advances in Gadolinium Based Contrast Agents for Bioimaging Applications

Recent Advances in Gadolinium Based Contrast Agents for Bioimaging Applications

Preparation of Polymeric Nanomaterials Using Emulsion Polymerization

Overcoming MDR by Associating Doxorubicin and pH-Sensitive PLGA Nanoparticles Containing a Novel Organoselenium Compound—An In Vitro Study

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