Drug nanocrystals

Fernandes, Ana Rita; Dias-Ferreira, João; Silva, Classius Ferreira da; Severino, Patrícia; Martins-Gomes, Carlos; Silva, Amélia M.; Souto, Eliana B.

doi:10.1016/b978-0-12-813741-3.00011-x

Cited by 7 publications

(2 citation statements)

References 71 publications

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“…The transfer into the nanodimension is beneficial as it increases poorly soluble compounds’ surface area and dissolution velocity. Thus, absorption from the gastrointestinal tract into the bloodstream can be improved [ 99 ].…”

Section: Nanocrystalsmentioning

confidence: 99%

Fisetin—In Search of Better Bioavailability—From Macro to Nano Modifications: A Review

Szymczak,

Cielecka-Piontek

2023

IJMS

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As secondary plant metabolites, polyphenols are abundant in fruits and vegetables. They are in high demand because of their many health benefits. However, their low bioavailability makes them complex compounds to use for therapeutic purposes. Due to the limited solubility of phytocompounds, dietary supplements made from them may only be partially effective. Such molecules include fisetin, found in strawberries, and have shown great promise in treating Alzheimer’s disease and cancer. Unfortunately, because of their limited water solubility, low absorption, and poor bioavailability, the assistance of nanotechnology is required to allow them to fulfil their potential fully. Here, we provide evidence that nanodelivery methods and structure modifications can improve fisetin bioavailability, which is linked to improvements in therapeutic efficacy. An open question remains as to which nanocarrier should be chosen to meet the abovementioned requirements and be able to enhance fisetin’s therapeutic potential to treat a particular disease.

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Section: Nanocrystalsmentioning

confidence: 99%

Fisetin—In Search of Better Bioavailability—From Macro to Nano Modifications: A Review

Szymczak,

Cielecka-Piontek

2023

IJMS

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“…Molecular laboratory tests could not only make the identification of resistance faster, but they could also be more susceptible and useful in the case of colonization and/or infections caused by fastidious microorganisms, giving the clinician a timely response to reduce the empirical use of antimicrobial drugs [10]. Betalactams are the class of antimicrobials most affected by resistance in general, which is conferred in gramnegatives, mainly by the bla gene family [11,12,13]. Therefore, we seek to develop a molecular assay, capable of identifying all variants of the most relevant genes of the bla family, these being: blaSHV, blaTEM, blaNDM, blaKPC, blaGES, blaCTX-M.…”

Section: Introductionmentioning

confidence: 99%

Molecular Insights into β-Lactams Resistance inKlebsiella pneumoniaeClinical Isolates with a Focus on Multidrug Resistance and Virulence

Nogueira,

Maia,

Clementino

et al. 2023

Preprint

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Klebsiella pneumoniae is associated with high resistance to antimicrobials and is common in isolates from colonization and nosocomial infections. The study aims to detect resistance genes belonging to the bla family and investigate metabolic pathways in K. pneumoniae isolates. Genes from the subfamilies included: blaSHV, blaTEM, blaNDM, blaKPC, blaGES, blaCTX-M and relevant variants of the blaOXA subfamily. Mass spectrometry data were acquired on the Orbitrap IDX spectrometer (Thermo) connected to the Vanquish UPLC system. Isolates from 122 K. pneumoniae samples were collected from 04/23/2019 to 05/29/2021. A high prevalence of resistance to penicillins, cephalosporins and carbapenems was found among the isolates. The identified genotypic profile showed a high prevalence of genes belonging to Ambler's classes of beta-lactamases A, B and D. In the metabolomic study, the N-fructosyl isoleucine metabolite was identified increased in multidrug-resistant (MDR) strains of K pneumoniae compared to strains susceptible to antimicrobials. In conclusion, the assays developed were efficient in detecting the main genes of the bla family of resistance in K. pneumoniae. The use of the pentose phosphate metabolic pathway suggests the regulation of bacterial growth, virulence, and colonization in MDR K. pneumoniae strains.

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Sustainable Clean Energy Production from the Bio-electrochemical Process Using Cathode as Nanocatalyst

Kachroo

Chaurasia

et al. 2022

Handbook of Green and Sustainable Nanotechnology

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Drug nanocrystals

Cited by 7 publications

References 71 publications

Fisetin—In Search of Better Bioavailability—From Macro to Nano Modifications: A Review

Fisetin—In Search of Better Bioavailability—From Macro to Nano Modifications: A Review

Molecular Insights into β-Lactams Resistance inKlebsiella pneumoniaeClinical Isolates with a Focus on Multidrug Resistance and Virulence

Sustainable Clean Energy Production from the Bio-electrochemical Process Using Cathode as Nanocatalyst

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