Drug polarity effect over the controlled release in casein and chondroitin sulfate-based hydrogels

Simão, Andressa Renatta; Fragal, Vanessa H.; Pellá, Michelly Cristina Galdioli; Garcia, Francielle P.; Nakamura, Celso V.; Silva, Rafael; Tambourgi, Elias Basile; Rubira, Adley F.

doi:10.1016/j.ijbiomac.2020.04.179

Cited by 14 publications

(9 citation statements)

References 40 publications

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“…The excitement surrounding green polymers lies not only in their renewability, biodegradability, and relatively low cost 1 but also in their eco-friendly character, which is capable of preventing the buildup of waste. 2,3 Proteins and polysaccharides are examples of natural (therefore, green) polymers commonly used in materials science for the most varied applications like food coatings, 4 hydrogels, 5 scaffolds, 6 wound dressings, 7 and so on.…”

Section: Introductionmentioning

confidence: 99%

Adjusting Experimental Parameters to Modify Corn Starch with Glycidyl Methacrylate to Tune Specific Properties

Pellá¹,

Simão²,

Maurício³

et al. 2023

J. Braz. Chem. Soc.

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Chemical modification reactions are viable alternatives for improving the properties of starch because they allow the insertion of molecules that change the original behavior of the polymer. Glycidyl methacrylate (GMA) is an example of a vinylic molecule added to starch to decrease its hydrophilicity and improve mechanical properties. This modification reaction is affected by parameters like the volume of the modifier, time, and temperature. Furthermore, the correlation between these parameters might change the response of an individual parameter on the degree of substitution (DS), crystallinity (Xc), and molecular-weight-related parameters. This work evaluated how these effects and their correlations would affect the DS, Xc, molecular weight, and the polydispersity index (PDI) of starch. The results suggested that, while higher volumes of GMA and temperatures decreased the DS and Xc, the correlation between them increased the DS by 2.47, and Xc by 1.25. On the other hand, higher temperatures also favored the occurrence of hydrolysis. Also, although none of the parameter correlations had a significant effect on the assessed properties (at 95%), the statistical analysis confirmed that the correlation between two parameters changed the effect of individual parameters.

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Section: Introductionmentioning

confidence: 99%

Adjusting Experimental Parameters to Modify Corn Starch with Glycidyl Methacrylate to Tune Specific Properties

Pellá¹,

Simão²,

Maurício³

et al. 2023

J. Braz. Chem. Soc.

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“…Polymers have the ability to bind solid dosage form particles. Taste masking, controlled release (e.g., prolonged, pulsatile, and targeted), better stability, and higher bioavailability are all common uses for pharmaceutical polymers 31 – 35 . Non-biodegradable polymers with strong biocompatibility like ethyl cellulose are also utilized as drug carriers (degradable but non biodegradable).…”

Section: Introductionmentioning

confidence: 99%

Impact of dispersion time interval and particle size on release profiles of propranolol HCl and carbamazepines from microparticle blends system

Muhaimin

Chaerunisaa

Bodmeier

2022

Sci Rep

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The objective of this study was to investigate the effect of dispersion time interval (DTI) on physicochemical properties of drug following the incorporation of propranolol HCl (Pro) and carbamazepine (CBZ) within ethyl cellulose (EC) microparticle blends using solvent evaporation method. The first Pro emulsion and second CBZ oil phase were dispersed in an external aqueous phase, with DTI of 0 and 60 min. The morphology of microparticle blends were characterized by SEM. The particle size mean of the emulsion droplets/hardened microparticles were monitored by FBRM. Encapsulation efficiency (EE) and in vitro drug release were also investigated. The resulting microparticle blends were spherical and formed two populations. The particle size mean of microparticle blends ranged from 113.27 µm to 122.42 µm. The EE was 77.28% to 78.64% for Pro and 96.48% to 98.64% for CBZ. FBRM studies showed that the size of microparticle blend prepared as W/O/W (Pro) and O/W (CBZ) system with DTI of 60 min and stirring time 4 h were larger than those prepared with DTI of 0 min. In vitro drug release studies after 28 days that revealed the CBZ release (58.72%) was faster than Pro release (43.16%). Investigation on surface morphology by SEM showed that the second drug CBZ which added as the oil phase in the W/O/W emulsion system had blocked the pores on the surface Pro microparticles prepared from the first primary emulsion, therefore affecting the drug release. This blocking effects of second drug (CBZ) on first emulsion microparticles (Pro) depended on the DTI. This phenomenon is only applicable if the first primary emulsion is W/O/W system.

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“…The porous structure of hydrogels promotes the combination of biological active agents with swelling water. This causes the hydrogel network structure to expand, thus promoting release of encapsulated materials [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Characterization of Chicken- and Bovine-Derived Chondroitin Sulfate/Sodium Alginate Hybrid Hydrogels

Zhao

Lan

et al. 2022

Gels

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The physicochemical properties and microstructure of hybrid hydrogels prepared using sodium alginate (SA) and chondroitin sulfate (CS) extracted from two animal sources were investigated. SA-based hybrid hydrogels were prepared by mixing chicken- and bovine-derived CS (CCS and BCS, respectively) with SA at 1/3 and 2/3 (w/w) ratios. The results indicated that the evaporation water loss rate of the hybrid hydrogels increased significantly upon the addition of CS, whereas CCS/SA (2/3) easily absorbed moisture from the environment. The thermal stability of the BCS/SA (1/3) hybrid hydrogel was higher than that of CCS/SA (1/3) hybrid hydrogel, whereas the hardness and adhesiveness of the CCS/SA (1/3) hybrid hydrogel were lower and higher, respectively, than those of the BCS/SA (1/3) hybrid hydrogel. Low-field nuclear magnetic resonance experiments demonstrated that the immobilized water content of the CCS/SA (1/3) hybrid hydrogel was higher than that of the BCS/SA (1/3) hybrid hydrogel. FTIR showed that S=O characteristic absorption peak intensity of BCS/SA (2/3) was obviously higher, suggesting that BCS possessed more sulfuric acid groups than CCS. SEM showed that the hybrid hydrogels containing CCS have more compact porous microstructure and better interfacial compatibility compared to BCS.

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Drug polarity effect over the controlled release in casein and chondroitin sulfate-based hydrogels

Cited by 14 publications

References 40 publications

Adjusting Experimental Parameters to Modify Corn Starch with Glycidyl Methacrylate to Tune Specific Properties

Adjusting Experimental Parameters to Modify Corn Starch with Glycidyl Methacrylate to Tune Specific Properties

Impact of dispersion time interval and particle size on release profiles of propranolol HCl and carbamazepines from microparticle blends system

Fabrication and Characterization of Chicken- and Bovine-Derived Chondroitin Sulfate/Sodium Alginate Hybrid Hydrogels

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