Drug-polymer interaction affecting the mechanical properties, adhesion strength and release kinetics of piroxicam-loaded Eudragit E films plasticized with different plasticizers

Lin, Shan‐Yang; Lee, Chau-Jen; Lin, Yih-Yih

doi:10.1016/0168-3659(94)00109-8

Cited by 80 publications

(49 citation statements)

References 13 publications

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“…The expected effect of a plasticizer is a decrease in the TS and an increase in the EB% [26,46]. It is shown that trehalose exhibits an "antiplasticization" effect [26] because it increases TS and decreases EB% and none of the molecules tested acts as a true plasticizer [26,46].…”

Section: Mechanical Propertiesmentioning

confidence: 99%

“…It is shown that trehalose exhibits an "antiplasticization" effect [26] because it increases TS and decreases EB% and none of the molecules tested acts as a true plasticizer [26,46]. A strong interaction between trehalose and the polymers might be occurring, decreasing the molecular mobility of the polymers.…”

Section: Mechanical Propertiesmentioning

confidence: 99%

“…Glycerol at 20% and 40% induced an increase in the PAF and WA in the films. In a study performed on piroxicam-loaded Eudragit E films the plasticizer was also able to increase the adhesion strength of the films [46].…”

Section: Bioadhesionmentioning

confidence: 99%

“…Films intended for skin drug delivery must be flexible enough to follow the movements of the skin and provide a good feel, and at the same time resist the mechanical abrasion caused, for example, by clothes. For simplicity we consider that a film for skin drug delivery should be hard (high TS) and tough (high EB%) [46].…”

Section: Mechanical Propertiesmentioning

confidence: 99%

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Films based on chitosan polyelectrolyte complexes for skin drug delivery: Development and characterization

Silva

Pereira

Ramalho

et al. 2008

Journal of Membrane Science

117

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a b s t r a c tNovel chitosan based polyelectrolyte complexes (PEC) were developed and optimized in order to obtain films possessing the optimal functional properties (flexibility, resistance, water vapour transmission rate and bioadhesion) to be applied on skin. The development was based on the combination of chitosan and two polyacrylic acid (PAA) polymers with different crosslinkers and crosslinking densities. The interaction between the polymers was maximized controlling the pH, and by forming the films at a pH value close to the pK a of the respective components as identified by potentiometric and turbidimetric titrations. The action of glycerol, PEG200, Hydrovance and trehalose upon the functional properties of the films was also evaluated. Glycerol was found to improve the film properties in terms of flexibility, resistance and water vapour transmission rate (WVTR) with a maximum effect at 30%. The application of a pressure sensitive adhesive (PSA) significantly improved bioadhesion with a negligible influence in the resistance and flexibility of the films.The optimized film, including adhesive, has shown very good properties for application in the skin and represents a very promising formulation for further incorporation of drugs for topical and transdermal administration.

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Section: Mechanical Propertiesmentioning

confidence: 99%

Section: Mechanical Propertiesmentioning

confidence: 99%

Section: Bioadhesionmentioning

confidence: 99%

Section: Mechanical Propertiesmentioning

confidence: 99%

See 2 more Smart Citations

Films based on chitosan polyelectrolyte complexes for skin drug delivery: Development and characterization

Silva

Pereira

Ramalho

et al. 2008

Journal of Membrane Science

117

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“…Data fi tting to Equation 1 revealed that only 6.4mg of piperine was released within that time interval, corresponding to 50% of the total amount incorporated into the device (13mg). In most CRDs, only a portion of the active agents is released, due to interactions between the polymeric materials and active substance retention (45) . Thus, the reduced activity may be attributed to degradation of piperine and the retention of the active components in the polymer matrix.…”

Section: Discussionmentioning

confidence: 99%

A biodegradable device for the controlled release of Piper nigrum (Piperaceae) standardized extract to control Aedes aegypti (Diptera, Culicidae) larvae

Custódio

Oliveira

Moterle

et al. 2016

Rev. Soc. Bras. Med. Trop.

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Introduction:The signifi cant increase in dengue, Zika, and chikungunya and the resistance of the Aedes aegypti mosquito to major insecticides emphasize the importance of studying alternatives to control this vector. The aim of this study was to develop a controlled-release device containing Piper nigrum extract and to study its larvicidal activity against Aedes aegypti. Methods: Piper nigrum extract was produced by maceration, standardized in piperine, and incorporated into cotton threads, which were inserted into hydrogel cylinders manufactured by the extrusion of carrageenan and carob. The piperine content of the extract and thread reservoirs was quantifi ed by chromatography. The release profi le from the device was assessed in aqueous medium and the larvicidal and residual activities of the standardized extract as well as of the controlled-release device were examined in Aedes aegypti larvae. Results: The standardized extract contained 580mg/g of piperine and an LC 50 value of 5.35ppm (24h) and the 3 cm thread reservoirs contained 13.83 ± 1.81mg of piperine. The device showed zero-order release of piperine for 16 days. The P. nigrum extract (25ppm) showed maximum residual larvicidal activity for 10 days, decreasing progressively thereafter. The device had a residual larvicidal activity for up to 37 days. Conclusions: The device provided controlled release of Piper nigrum extract with residual activity for 37 days. The device is easy to manufacture and may represent an effective alternative for the control of Aedes aegypti larvae in small water containers.

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Adhesives in Dermal Patches

Lal,

Gaur,

Verma

2023

Adhesives in Biomedical Applications

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Drug-polymer interaction affecting the mechanical properties, adhesion strength and release kinetics of piroxicam-loaded Eudragit E films plasticized with different plasticizers

Cited by 80 publications

References 13 publications

Films based on chitosan polyelectrolyte complexes for skin drug delivery: Development and characterization

Films based on chitosan polyelectrolyte complexes for skin drug delivery: Development and characterization

A biodegradable device for the controlled release of Piper nigrum (Piperaceae) standardized extract to control Aedes aegypti (Diptera, Culicidae) larvae

Adhesives in Dermal Patches

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