Drug Reactions

Breathnach, S.M.; BChir,; Dermatologist, Frcp Consultant

doi:10.1002/9781444317633.ch75

Cited by 40 publications

(35 citation statements)

References 3,869 publications

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“…FDE is commonly associated with NSAIDs, tetracyclins, doxycyclin, cotrimoxazole, pencillins, cephalosporins and phenobarbitone, Exfoliative dermatitis is known to be induced by antibiotics, NSAIDs, dapsone, anticonvulsants etc., Macrolide antibiotics, hydroxychloroquin, and diltiazem are well known to induce AGEP. [ 10 ] The female patient who presented with multiple lesions of FDE gave a history of recurrent attacks of one or two FDE lesions for the past one year. A detailed drug history revealed that she was receiving amitryptilline and NSAID for peripheral neuropathy intermittently during the above mentioned period.…”

Section: Discussionmentioning

confidence: 99%

Severe cutaneous adverse drug reactions: A clinicoepidemiological study

et al. 2015

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Background:Drug eruptions range from transient erythema to the life threatening severe cutaneous adverse reactions (SCAR) that encompass Stevens–Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP) and drug reaction with eosinophilia and systemic symptoms complex (DRESS).Aims and Objectives:To study the clinical and epidemiological aspects of cutaneous adverse drug reactions (CADR).Materials and Methods:Ethical clearance was obtained from the institutional ethics committee. All patients admitted in the Dermatology ward of our tertiary care hospital with CADR (those who fit in the category of probable or possible drug reaction as per WHO casuality assessment) from first September 2011 to 31st August 2012 were included in this cross sectional study after obtaining written informed consent. The drug reaction patterns observed in the study population were determined and the common offending drugs were identified.Results:In the study, population of males outnumbered females and the majority were between 46 and 60 years of age. The commonest reaction pattern observed was SJS- TEN spectrum of illness and aromatic anticonvulsants were the common offending drugs. Prompt withdrawal of the culprit drug and administration of systemic steroids with or without I/V Ig reverted the adverse reaction in all except one.Conclusion:Severe drug reactions predominated as the study population was comprised of inpatients of a tertiary referral centre. Though; previous authors had reported a mortality rate of up to 20% in DRESS, all our patients with this reaction pattern, responded well to treatment. The mortality rate among TEN cases was much lower than the previous reports. Early diagnosis, prompt withdrawal of the suspected drug, careful monitoring for development of complications and immediate intervention can improve the prognosis of CADR.

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Section: Discussionmentioning

confidence: 99%

Severe cutaneous adverse drug reactions: A clinicoepidemiological study

et al. 2015

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“…Fixed drug eruption is a distinctive drug induced reaction pattern characterized by recurrence of eruption at the same site of the skin or mucous membrane with repeated systemic administration of the drug. [ 5 ] It was first described by Bourns and later on by Brocq. FDE is the most common cutaneous drug reaction described in India, being somewhat more common in this part of the globe; a finding ascribed to genetic factors.…”

Section: Discussionmentioning

confidence: 99%

“…[ 7 ] Common drugs incriminated in causing FDE are trimethoprim-sulfamethoxazole, tetracycline, penicillin, nonsteroidal anti-inflammatory drugs like aspirin, diclofenac sodium, naproxen and ibuprofen. [ 5 ]…”

Section: Discussionmentioning

confidence: 99%

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Fixed drug eruptions with modafinil

Ghoshal

Sinha

2015

Indian J Pharmacol

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Modafinil is a psychostimulant drug, which has been approved by the US Food and Drug Administration for the treatment of narcolepsy associated excessive daytime sleepiness, sleep disorder related to shift work, and obstructive sleep apnea syndrome. However, presently it is being used as a lifestyle medicine; in India, it has been misused as an “over the counter” drug. Modafinil is known to have several cutaneous side effects. Fixed drug eruption (FDE) is a distinctive drug induced reaction pattern characterized by recurrence of eruption at the same site of the skin or mucous membrane with repeated systemic administration. Only two case reports exist in the literature describing modafinil induced FDE until date. Here, we report two similar cases. The increasing use of this class of drug amongst the medical personnel might be posing a threat to the proper use and encouraging subsequent abuse. There might be a considerable population using these drugs unaware of the possible adverse effects. Authorities should be more alert regarding the sale and distribution of such medicines.

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“…Oral lichenoid drug eruptions have been reported in association with an extensive list of medications. The most commonly implicated drug classes include: penicillamine (5,18), antimalarials (19), gold salts (5,12), antihypertensives, including β ‐blockers (4,5,18,20,21) and angiotensin inhibitors (5,6,21–23), nonsteroidal antiinflammatory drugs (5,24,25), and HIV medications (5,26,27). The time from initial medication intake to lesion appearance is variable, ranging from weeks to months with an average delay in onset of 2–3 months (6).…”

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confidence: 99%

Oral Lichenoid Drug Eruption: A Report of a Pediatric Case and Review of the Literature

Woo

Bonks

Borukhova

et al. 2009

Pediatric Dermatology

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Lichenoid drug eruptions are seen most frequently on the skin and seldomly affect the mucosal surfaces. Oral involvement-known as oral lichenoid drug eruption-is more common in the adult population and has been associated with numerous medications. Pediatric-onset oral lichenoid drug eruption is an exceptionally rare finding with only isolated cases published in the literature. The nonspecific appearance and latent presentation of pediatric oral lichenoid drug eruption can cause confusion in diagnosis and treatment. We report a case of oral lichenoid drug eruption occurring in a 15-year-old and explore challenges in the clinical and histologic recognition of this condition.

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Drug Reactions

Cited by 40 publications

References 3,869 publications

Severe cutaneous adverse drug reactions: A clinicoepidemiological study

Severe cutaneous adverse drug reactions: A clinicoepidemiological study

Fixed drug eruptions with modafinil

Oral Lichenoid Drug Eruption: A Report of a Pediatric Case and Review of the Literature

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