Drug release from hydrogel-based matrix systems partially coated: experiments and modeling

Piano, Raffaella De; Caccavo, Diego; Cascone, Sara; Festa, Caterina; Lamberti, Gaetano; Barba, Anna Angela

doi:10.1016/j.jddst.2020.102146

Cited by 12 publications

(10 citation statements)

References 23 publications

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“…The sustained and controlled drug release from the polymeric matrix of the hydrogel is always challenging due to its complex releasing mechanism. It has four fundamental parameters to control drug releases: diffusion, solvent, degradation, erosion, and swelling. , In the erosion mechanism, drug delivery occurs due to a hydrolytic process, and the polymeric matrix of hydrogels begins to degrade at the edges and margins to release the drug . Diffusion mechanisms release drugs from the hydrogel polymeric matrix when there is a concentration difference.…”

Section: Resultsmentioning

confidence: 99%

“… 38 , 39 In the erosion mechanism, drug delivery occurs due to a hydrolytic process, and the polymeric matrix of hydrogels begins to degrade at the edges and margins to release the drug. 40 Diffusion mechanisms release drugs from the hydrogel polymeric matrix when there is a concentration difference. The swelling of hydrogels is directly related to diffusion that interacts with body fluids and swells by absorbing biofluids to release the drug.…”

Section: Resultsmentioning

confidence: 99%

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Graphene Oxide-Functionalized Bacterial Cellulose–Gelatin Hydrogel with Curcumin Release and Kinetics: In Vitro Biological Evaluation

Khan,

Stojanović,

Rehman

et al. 2023

ACS Omega

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Biopolymer-based bioactive hydrogels are excellent wound dressing materials for wound healing applications. They have excellent properties, including hydrophilicity, tunable mechanical and morphological properties, controllable functionality, biodegradability, and desirable biocompatibility. The bioactive hydrogels were fabricated from bacterial cellulose (BC), gelatin, and graphene oxide (GO). The GO-functionalized-BC (GO-f-BC) was synthesized by a hydrothermal method and chemically crosslinked with bacterial cellulose and gelatin using tetraethyl orthosilicate (TEOS) as a crosslinker. The structural, morphological, and wettability properties were studied using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and a universal testing machine (UTM), respectively. The swelling analysis was conducted in different media, and aqueous medium exhibited maximum hydrogel swelling compared to other media. The Franz diffusion method was used to study curcumin (Cur) release (Max = 69.32%, Min = 49.32%), and Cur release kinetics followed the Hixson−Crowell model. Fibroblast (3T3) cell lines were employed to determine the cell viability and proliferation to bioactive hydrogels. Antibacterial activities of bioactive hydrogels were evaluated against infectioncausing bacterial strains. Bioactive hydrogels are hemocompatible due to their less than 0.5% hemolysis against fresh human blood. The results show that bioactive hydrogels can be potential wound dressing materials for wound healing applications.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Graphene Oxide-Functionalized Bacterial Cellulose–Gelatin Hydrogel with Curcumin Release and Kinetics: In Vitro Biological Evaluation

Khan,

Stojanović,

Rehman

et al. 2023

ACS Omega

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“…For this reason, a handful of experimental results can be used as a reference for validating the simulation. In this research, the experimental results presented by De Piano et al published in 2021 [ 40 ] and the experimental results presented in the research by Lamberti et al [ 25 ] have been used. The first study [ 40 ] presents the experimental results for three rotation speeds of the paddle in the dissolution test process.…”

Section: Methodsmentioning

confidence: 99%

Tablet Geometry Effect on the Drug Release Profile from a Hydrogel-Based Drug Delivery System

Mohseni-Motlagh,

Dolatabadi,

Baniassadi

et al. 2023

Pharmaceutics

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In order to achieve the optimal level of effectiveness and safety of drugs, it is necessary to control the drug release rate. Therefore, it is important to discover the factors affecting release profile from a drug delivery system. Geometry is one of these effective factors for a tablet-shaped drug delivery system. In this study, an attempt has been made to answer a general question of how the geometry of a tablet can affect the drug release profile. For this purpose, the drug release process of theophylline from two hundred HPMC-based tablets, which are categorized into eight groups of common geometries in the production of oral tablets, was simulated using finite element analysis. The analysis of the results of these simulations was carried out using statistical methods including partial least squares regression and ANOVA tests. The results showed that it is possible to predict the drug release profile by knowing the geometry type and dimensions of a tablet without performing numerous dissolution tests. Another result was that, although in many previous studies the difference in the drug release profile from several tablets with different geometries was interpreted only by variables related to the surface, the results showed that regardless of the type of geometry and its dimensions, it is not possible to have an accurate prediction of the drug release profile. Also, the results showed that without any change in the dose of the drug and the ingredients of the tablet and only because of the difference in geometry type, the tablets significantly differ in release profile. This occurred in such a way that, for example, the release time of the entire drug mass from two tablets with the same mass and materials but different geometries can be different by about seven times.

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“…FT-IR spectra were recorded from 400–4000 cm −1 with a resolution of 1 cm −1 using a PerkinElmer Spectrum 100 spectrophotometer (Perkin Elmer Corp., Norwalk, CT, USA). The spectra were processed using the SpectraGryph 1.2 spectroscopy software (Am Dummelsmoos 2887561, Oberstdorf, Germany) [ 40 ].…”

Section: Methodsmentioning

confidence: 99%

Methotrexate-Loaded Gelatin and Polyvinyl Alcohol (Gel/PVA) Hydrogel as a pH-Sensitive Matrix

et al. 2021

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The aim was to formulate and evaluate Gel/PVA hydrogels as a pH-sensitive matrix to deliver methotrexate (MTX) to colon. The primed Gel/PVA hydrogels were subjected to evaluation for swelling behavior, diffusion coefficient, sol-gel characteristic and porosity using an acidic (pH 1.2) and phosphate buffer (PBS) (pH 6.8 & pH 7.4) media. Fourier transform infrared spectroscopy (FTIR) and thermal gravimetric analysis (TGA) were performed to evaluate the chemical compatibility of the Gel/PVA hydrogel. The shape alteration and release of Gel/PVA hydrogel was conducted at pH 1.2, pH 6.8 and pH 7.4. The drug release kinetic mechanism was determined using various kinetic equations. The physicochemical evaluation tests and drug release profile results were found to be significant (p < 0.01). However, it was dependent on the polymers’ concentration, the pH of the release media and the amount of the cross-linking agent. Hydrogels containing the maximum amount of gel showed a dynamic equilibrium of 10.09 ± 0.18 and drug release of 93.75 ± 0.13% at pH 1.2. The kinetic models showed the release of MTX from the Gel/PVA hydrogel was non-Fickian. The results confirmed that the newly formed Gel/PVA hydrogels are potential drug delivery systems for a controlled delivery of MTX to the colon.

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Drug release from hydrogel-based matrix systems partially coated: experiments and modeling

Cited by 12 publications

References 23 publications

Graphene Oxide-Functionalized Bacterial Cellulose–Gelatin Hydrogel with Curcumin Release and Kinetics: In Vitro Biological Evaluation

Graphene Oxide-Functionalized Bacterial Cellulose–Gelatin Hydrogel with Curcumin Release and Kinetics: In Vitro Biological Evaluation

Tablet Geometry Effect on the Drug Release Profile from a Hydrogel-Based Drug Delivery System

Methotrexate-Loaded Gelatin and Polyvinyl Alcohol (Gel/PVA) Hydrogel as a pH-Sensitive Matrix

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