Drug Release Kinetics from Polymer Matrix through Fractal Approximation of Motion

Abstract

The present paper analyzes the process of drug release from polymer matrix. This process has been considered as fractal polymer process. Since complexity of physical processes is replaced by fractality, the paper studies the process through fractal approach. In drug dynamics, fractal "diffusion" equation can be obtained through fractal approximation of motion. All experimental release curves have been best demonstrated by Weibull relation (which was, in its turn, also demonstrated). Weibull parameters are related to the fractal dimension of drug release kinetics from a polymer matrix. Such a dimension can characterize and measure the complexity of the system. In the above-mentioned context, some experimental results of our researchers are presented and analyzed by comparing them with Peppas relation, a basic law in the description of drug release kinetics. Consequently, experimental data for Weibull relation are better correlated with certain resulting factors. At the same time, some conclusions regarding the phenomena involved in the process are considered as being based on the approach.

Dual‐analgesic loadedUHMWPEexhibits synergistic antibacterial effects againstStaphylococci

“…This indicates increased complexity and tortuosity of tolfenamic acid and bupivacaine clusters in the UHMWPE matrix. Previously we demonstrated that the initial release is primarily driven by the “small” drug clusters, 16 and increased fractal dimension is often associated with increased drug diffusion from the polymeric matrix 44,45 . We attribute the pronounced increase in the tolfenamic elution to the increased complexity and tortuosity of “small” drug clusters.…”