Drug release modulation by physical restrictions of matrix swelling

Starch-free grewia gum matrices: Compaction, swelling, erosion and drug release behaviour

“…This property has been utilized in the formulation of dosage forms (Nakano and Ogata, 1984) where the powdered drug is embedded within the matrix of hydrophilic polymeric materials and compressed to produce matrix tablets. The release of drug from such hydrophilic matrices is described as a complex interaction between swelling, diffusion and erosion (Harland et al, 1988;Peppas and Sahlin, 1989;Colombo et al, 1990;Lee and Kim, 55 1991; Colombo et al, 1992;Colombo et al, 1995;Reynolds et al, 1998;Munday and Cox, 2000;Ghori et al, 2014a).…”

Effects of polymer type, polymer: direct tabletting agent ratio and tabletting method on verapamil hydrochloride extended release from hydroxypropylmethylcellulose matrix tablets: polimer tipinin, pol

“…In order to delay the release of drug in the first four hours, F8 was modified by adding the same type of polymer layer to each face of the tablet, thus F9, F10 and F11 were prepared as threelayered matrix tablets (Table 1) (14,15,16,25). Among them, release profile of F9 which was layered with low viscosity grade polymer was found to be similar to pharmacopeial profiles ( Figure 4).…”

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“…Gastoretentive drug delivery system [27] As compared to other drug delivery system, oral drug delivery is the most convenient, easiest method of drug administration so it is the preferred method of administering therapeutic agents for their systemic effects. Oral medication is generally considered as the first avenue investigated in the development of pharmaceutical formulations because of patient acceptance, convenience in administration and cost-effective manufacturing processes.…”