Drug Repurposing for Tuberculosis

Cardoso, Nicole C.; Oosthuizen, Carel B.; Peton, Nashied; Singh, Vinayak

doi:10.5772/intechopen.101393

Drug Repurposing - Molecular Aspects and Therapeutic Applications 2022

DOI: 10.5772/intechopen.101393

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Drug Repurposing for Tuberculosis

Nicole C. Cardoso¹,

Carel B. Oosthuizen²,

Nashied Peton³

et al.

Abstract: Tuberculosis (TB), caused by Mycobacterium tuberculosis, is a major global health concern given the increase in multiple forms of drug-resistant TB. This underscores the importance of a continuous pipeline of new anti-TB agents. From recent studies, it is evident that the increase in drug efficacy is being achieved through re-engineering old TB-drug families and repurposing known drugs. This approach has led to producing a newer class of compounds which not only saves time and investment in developing newer dr… Show more

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2023

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Cited by 2 publications

References 53 publications

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Multitargeting: An Alternative Approach to Tackle Multidrug Resistance in Tuberculosis

Patra

Hazra

Hazarika

2023

CDT

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Background: The prevalence of drug-resistant organisms has steadily increased over the past few decades worldwide. Especially in tuberculosis (TB) disease, the problems of co-morbidity and the rapid emergence of multidrug resistance have necessitated the development of multitarget-based therapeutic regimens. Several multitargeting compounds against Mycobacterium tuberculosis (Mtb) have been studied through novel in silico tools but these have rendered reduced efficacy in clinical trials. The authors have focussed on many exotic targets belonging to crucial Mtb survival pathways whose molecular structures and functions are underexplored. Likewise, insights into the hidden possibilities of promiscuous compounds from natural products or repurposed drugs to inhibit other cellular proteins apart from their validated targets are also depicted in this review. In addition to the existing line of drugs currently recommended for multidrug-resistant TB, newer host-directed therapies could also be fruitful. Furthermore, several challenges, including safety/efficacy ratios of multitarget compounds highlighted here, can also be circumnavigated by researchers to design “smart drugs” for improved tuberculosis therapeutics. Conclusion: A holistic approach towards alleviating the existing drawbacks of drug discovery in drug-resistant TB has been outlined. Finally, considering the current needs, the authors have put forward an overall summary of possible trends in multitargeting that are significant for futuristic therapeutic solutions.

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Multitargeting: An Alternative Approach to Tackle Multidrug Resistance in Tuberculosis

Patra

Hazra

Hazarika

2023

CDT

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An overview of current strategies and future prospects in drug repurposing in tuberculosis

Singh

Chawla

2023

Exploration of Medicine

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A large number of the population faces mortality as an effect of tuberculosis (TB). The line of treatment in the management of TB faces a jolt with ever-increasing multi-drug resistance (DR) cases. Further, the drugs engaged in the treatment of TB are associated with different toxicities, such as renal and hepatic toxicity. Different combinations are sought for effective anti-tuberculosis (anti-TB) effects with a decrease in toxicity. In this regard, drug repurposing has been very promising in improving the efficacy of drugs by enhancement of bioavailability and widening the safety margin. The success in drug repurposing lies in specified binding and inhibition of a particular target in the drug molecule. Different drugs have been repurposed for various ailments like cancer, Alzheimer’s disease, acquired immunodeficiency syndrome (AIDS), hair loss, etc. Repurposing in anti-TB drugs holds great potential too. The use of whole-cell screening assays and the availability of large chemical compounds for testing against Mycobacterium tuberculosis poses a challenge in this development. The target-based discovery of sites has emerged in the form of phenotypic screening as ethionamide R (EthR) and malate synthase inhibitors are similar to pharmaceuticals. In this review, the authors have thoroughly described the drug repurposing techniques on the basis of pharmacogenomics and drug metabolism, pathogen-targeted therapy, host-directed therapy, and bioinformatics approaches for the identification of drugs. Further, the significance of repurposing of drugs elaborated on large databases has been revealed. The role of genomics and network-based methods in drug repurposing has been also discussed in this article.

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Drug Repurposing for Tuberculosis

Cited by 2 publications

References 53 publications

Multitargeting: An Alternative Approach to Tackle Multidrug Resistance in Tuberculosis

Multitargeting: An Alternative Approach to Tackle Multidrug Resistance in Tuberculosis

An overview of current strategies and future prospects in drug repurposing in tuberculosis

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