Drug resistance patterns among extra-pulmonary tuberculosis cases in a tertiary care centre in North India

Sharma, Surendra Kumar; Chaubey, Jigyasa; Singh, Binit Kumar; Sharma, Reetika; Mittal, Abhenil; Sharma, Abhishek

doi:10.5588/ijtld.16.0939

Cited by 34 publications

(21 citation statements)

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“…Moreover, high MDR-TB in our study might be due to the difference in the study setting where the current study is conducted in an urban setting. However, our findings were consistent with previous studies [26,28,30,37,38].…”

Section: Discussionsupporting

confidence: 94%

“…In this study, INH mono-resistance was 3 (2%) which is relatively similar to the earlier study reported from Ethiopia [29] and India [27]. Another study reported from North India [30] indicated a higher proportion of INH mono-resistance than our result. This difference could be due to variation in treatment adherence, mutations, early introduction of drugs in the country, and high dose INH use for MDR treatment.…”

Section: Discussionsupporting

confidence: 90%

“…The proportion of pre-XDR-TB cases among MDR-TB patients in the present study was 21.4% [3]. The finding of the current study is similar to the previous study reported from India in which the proportion of pre-XDR-TB among MDR-TB patients was 18.4% [30]. In contrast…”

Section: Discussionsupporting

confidence: 89%

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Molecular characterization and drug resistance patterns of Mycobacterium tuberculosis complex in extrapulmonary tuberculosis patients in Addis Ababa, Ethiopia

et al. 2020

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Background Molecular characterization of Mycobacterium tuberculosis (MTB) is important to understand the pathogenesis, diagnosis, treatment, and prevention of tuberculosis (TB). However, there is limited information on molecular characteristics and drug-resistant patterns of MTB in patients with extra-pulmonary tuberculosis (EPTB) in Ethiopia. Thus, this study aimed to determine the molecular characteristics and drug resistance patterns of MTB in patients with EPTB in Addis Ababa, Ethiopia. Methods This study was conducted on frozen stored isolates of EPTB survey conducted in Addis Ababa, Ethiopia. A drug susceptibility test was performed using BACTEC-MGIT 960. Species and strain identification were performed using the Geno-Type MTBC and spoligotyping technique, respectively. Data were entered into the MIRU-VNTRplus database to assess the spoligotype patterns of MTB. Analysis was performed using SPSS version 23, and participants’ characteristics were presented by numbers and proportions. Results Of 151 MTB isolates, 29 (19.2%) were resistant to at least one drug. The highest proportion of isolates was resistant to Isoniazid (14.6%) and Pyrazinamide (14.6%). Nine percent of isolates had multidrug-resistant TB (MDR-TB), and 21.4% of them had pre-extensively drug-resistant TB (pre-XDR-TB). Among the 151 MTB isolates characterized by spoligotyping, 142 (94.6%) had known patterns, while 9 (6.0%) isolates were not matched with the MIRU-VNTRplus spoligotype database. Of the isolates which had known patterns, 2% was M.bovis while 98% M. tuberculosis. Forty-one different spoligotype patterns were identified. The most frequently identified SpolDB4 (SIT) wereSIT149 (21.2%), SIT53 (14.6%) and SIT26 (9.6%). The predominant genotypes identified were T (53.6%), Central Asia Strain (19.2%) and Haarlem (9.9%). Conclusion The present study showed a high proportion of MDR-TB and pre-XDR-TB among EPTB patients. The strains were mostly grouped into SIT149, SIT53, and SIT26. The T family lineage was the most prevalent genotype. MDR-TB and pre-XDR-TB prevention is required to combat these strains in EPTB. A large scale study is required to describe the molecular characteristics and drug resistance patterns of MTB isolates in EPTB patients.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 90%

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Molecular characterization and drug resistance patterns of Mycobacterium tuberculosis complex in extrapulmonary tuberculosis patients in Addis Ababa, Ethiopia

et al. 2020

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“…In last decade, the use of several molecular diagnostic techniques like Xpert MTB/RIF and LPA have increased the DR-TB case notification rate worldwide 12 . RIF-resistant (RR) associated rpoB gene hotspot (codon 507-533) is identified as the principle RR-TB defining region in all the nucleic acid amplification tests based molecular diagnostics 13 .…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Evaluation of Non-Interpretable Results Associated with rpoB Gene in Genotype MTBDRplus Ver 2.0

et al. 2020

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“…It should be differentiated from other common respiratory diseases such as tuberculosis which contributes to over one-quarter (27.3%) of the global TB burden in India alone. (Sharma et al, 2017), (Sharma et al, 2018). It shows symptoms like cough with expectoration, weight loss, fatigue, night sweats and evening rise in temperature.…”

Section: Figure 1: Renin Angiotensin System (Ras)mentioning

confidence: 99%

Role of Vitamin D in prevention of Corona virus infection (COVID-19)

Juneja¹,

Dangore–Khasbage²,

Bhowate³

2020

ijrps

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Corona viruses enveloped positive-sense RNA viruses causes various diseases in mammals as well as birds which range from upper respiratory tract infection to potentially lethal human respiratory syndrome. In humans, Severe Acute Respiratory Syndrome corona virus 2 (SARS-CoV-2) causing corona virus disease 2019 (COVID-19) which shows symptoms like fever, sore throat, gasping and ultimately pneumonia, lung injury and leading to death. The virus acts on various systems of our body, and one of them is the Renin-Angiotensin system. It is supposed that the virus causes cell injury by acting on Angiotensin-Converting Enzyme 2 (ACE2) receptors which causes an increase in the level of Angiotensin II, leading to inflammation and lung injury. An essential vitamin can prevent this in our body that is vitamin D. It acts on Renin-Angiotensin system (RAS) by inhibiting the action of renin and also by increasing production of ACE2 and hence Angiotensin II level decreases which prevent inflammation and lung injury. So vitamin D has a remarkable and pivotal role in modulation of the immune system of our body and hence protects human from this fatal disease.

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Drug resistance patterns among extra-pulmonary tuberculosis cases in a tertiary care centre in North India

Abstract: The burden of drug resistance, including M/XDR-TB, among EPTB patients is high. Novel molecular tests can help in early diagnosis and treatment to prevent disease progression and amplification of resistance.

Cited by 34 publications

References 0 publications

Molecular characterization and drug resistance patterns of Mycobacterium tuberculosis complex in extrapulmonary tuberculosis patients in Addis Ababa, Ethiopia

Molecular characterization and drug resistance patterns of Mycobacterium tuberculosis complex in extrapulmonary tuberculosis patients in Addis Ababa, Ethiopia

Diagnostic Evaluation of Non-Interpretable Results Associated with rpoB Gene in Genotype MTBDRplus Ver 2.0

Role of Vitamin D in prevention of Corona virus infection (COVID-19)

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