Drug Resistance Patterns and Trends in Patients with Suspected Drug-Resistant Tuberculosis in Dalian, China: A Retrospective Study

Pan, Yuanping; Yu, Yingying; Lu, Jiachen; Yi, Yaohui; Dou, Xiaofeng; Zhou, Ling

doi:10.2147/idr.s373125

Cited by 9 publications

(4 citation statements)

References 32 publications

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“…The emergency of drug-resistant TB (DR-TB) has threatened global public health efforts to control TB [3,4]. China has the third-highest burden of MTB in the world [5], in particular a significant increase in DR-TB, which severely impacts treatment outcomes [6]. The timely diagnosis and treatment of TB, particularly DR-TB, contributes to controlling the transmission of the disease [2].…”

Section: Introductionmentioning

confidence: 99%

Drug Resistance and Molecular Characteristics of Mycobacterium tuberculosis: A Single Center Experience

Chen

Feng

et al. 2022

JPM

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In recent years, the incidence of tuberculosis (TB) and mortality caused by the disease have been decreasing. However, the number of drug-resistant tuberculosis patients is increasing rapidly year by year. Here, a total of 380 Mycobacterium tuberculosis (MTB)-positive formalin-fixed and paraffin-embedded tissue (FFPE) specimens diagnosed in the Department of Pathology of the Eighth Medical Center, Chinese PLA General Hospital were collected. Among 380 cases of MTB, 85 (22.37%) were susceptible to four anti-TB drugs and the remaining 295 (77.63%) were resistant to one or more drugs. The rate of MDR-TB was higher in previously treated cases (52.53%) than in new cases [(36.65%), p < 0.05]. Of previously treated cases, the rate of drug resistance was higher in females than in males (p < 0.05). Among specimens obtained from males, the rate of drug resistance was higher in new cases than in previously treated cases (p < 0.05). Of mutation in drug resistance-related genes, the majority (53/380, 13.95%) of rpoB gene carried the D516V mutation, and 13.42% (51/380) featured mutations in both the katG and inhA genes. Among the total specimens, 18.68% (71/380) carried the 88 M mutation in the rpsL gene, and the embB gene focused on the 306 M2 mutation with a mutation rate of 19.74%. Among the resistant INH, the mutation rate of −15 M was higher in resistance to more than one drug than in monodrug-resistant (p < 0.05). In conclusion, the drug resistance of MTB is still very severe and the timely detection of drug resistance is conducive to the precise treatment of TB.

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Section: Introductionmentioning

confidence: 99%

Drug Resistance and Molecular Characteristics of Mycobacterium tuberculosis: A Single Center Experience

Chen

Feng

et al. 2022

JPM

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“…Located in East China, Nanjing is an ancient capital with a relatively developed economy and profound cultural heritage. In Nanjing, studies have shown that the total rate of DR-TB during 2017–2020 was 32.7% [ 28 ], lower than that during 2002–2014 (49.53 ± 8.57%) [ 29 ] but still higher than that in the areas of Hainan (24.9%) [ 30 ], Dalian (29.59%) [ 31 ] and Hangzhou (23.82%) [ 32 ] in China. At the same time, a meta-analysis also noted out that the prevalence of any drug resistance among new and retreatment cases was significantly higher in eastern China than in other regions of China [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Assessing the quality of life in patients with drug-resistant tuberculosis: a cross-sectional study

Wang,

Gu,

Zhang

et al. 2024

BMC Pulm Med

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Background This study investigated the current status of the quality of life (QOL) of drug-resistant tuberculosis (DR-TB) patients in Nanjing, China, and analyzed the influencing factors. Methods The survey was conducted among patients with DR-TB who were hospitalized in the tuberculosis department of the Second Hospital of Nanjing (Nanjing Public Health Medical Center) from July 2022 to May 2023. The Chinese version of the World Health Organization Quality of Life (WHOQOL-BREF) questionnaire was used to investigate the QOL levels of patients with DR-TB, and a multiple linear regression model was used to analyze the QOL influencing factors. Results A total of 135 patients participated in the study; 69.6% were male, the average age was 46.30 ± 17.98 years, 13.33% had an education level of elementary school or below, and 75.56% were married. The QOL scores were 51.35 ± 17.24, 47.04 ± 20.28, 43.89 ± 17.96, and 35.00 ± 11.57 in the physiological, psychological, social, and environmental domains, respectively. The differences between the four domain scores and the Chinese normative results were statistically significant (P < 0.05). The results of multiple linear regression analysis showed that the factors related to the physiological domain included residence, family per-capita monthly income, payment method, adverse drug reactions (ADRs), and comorbidities; psychological domain correlates included educational level, family per-capita monthly income, course of the disease, and caregivers; social domain correlates included age and comorbidities; and factors related to the environmental domain included age, education level, and comorbidities. Conclusions In Nanjing, China, patients with younger age, higher education level, living in urban areas, high family per-capita monthly income, no adverse drug reactions, no comorbidities, and having caregivers have better quality of life. Future interventions to improve the quality of life of patients with drug-resistant tuberculosis could be tailored to a specific factor.

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“…The World Health Organization (WHO) proposed a strategy to eliminate TB, which was to reduce TB mortality to less than 95% and incidence to 90% by 2035 [2]. However, the emergence of drug-resistant TB (DR-TB) has seriously hindered the prevention and treatment of TB [3]. DR-TB is now becoming the world's deadliest pathogen, with a quarter of deaths attributed to antimicrobial drug resistance [4].…”

Section: Introductionmentioning

confidence: 99%

The differences in drug resistance between drug-resistant tuberculosis patients with and without diabetes mellitus in northeast China: a retrospective study

Pan

et al. 2023

BMC Infect Dis

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Background Diabetes mellitus (DM) and drug-resistant tuberculosis (DR-TB) are serious global public health problems. This study aimed to explore the differences in drug resistance between DR-TB patients with and without DM. Risk factors for developing multidrug-resistant tuberculosis (MDR-TB) were also investigated among DR-TB patients. Methods The patient’s basic demographic,　clinical characteristics, and drug susceptibility testing (DST) data were collected from the Chinese Disease Control Information System. Descriptive statistics were used to estimate the frequency and proportion of included variables. Categorical variables were compared using the Chi-square test or Fisher’s exact test. Chi-square tests for trends were used to determine changes and trends in MDR-TB and pre-extensively drug-resistantTB (pre-XDR-TB) patterns over time. Univariate and multivariate logistic regression analysis was used to explore the risk factors of MDR-TB. Results Compared with DR-TB patients with DM, DR-TB patients without DM had significantly higher rates of mono-resistant streptomycin (SM) and any resistance to kanamycin (KM), but significantly lower rates of any resistance to protionamide (PTO) and mono-resistance to levofloxacin (LFX), and pre-XDR-TB (P<0.05). The proportion of resistance to other anti-TB drugs was not statistically different between the DR-TB with and without DM. Among DR-TB patients without and with DM, the proportion of patients with MDR-TB and pre-XDR-TB patterns showed a significant downward trend from 2016 to 2021 (P<0.05). Among DR-TB patients without DM, male, previously treated DR-TB cases, and immigration were risk factors for MDR-TB (P<0.05). In DR-TB patients with DM, a negative sputum smear is a risk factor for MDR-TB (P<0.05). Conclusion There was no statistical difference in resistance patterns between DR-TB with and without DM, except in arbitrary resistance to PTO and KM, mono-resistant SM and LFX, and pre-XDR-TB. Great progress has been made in the prevention and control of MDR-TB and pre-XDR-TB. However, DR-TB patients with and without DM differ in their risk factors for developing MDR-TB.

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Drug Resistance Patterns and Trends in Patients with Suspected Drug-Resistant Tuberculosis in Dalian, China: A Retrospective Study

Cited by 9 publications

References 32 publications

Drug Resistance and Molecular Characteristics of Mycobacterium tuberculosis: A Single Center Experience

Drug Resistance and Molecular Characteristics of Mycobacterium tuberculosis: A Single Center Experience

Assessing the quality of life in patients with drug-resistant tuberculosis: a cross-sectional study

The differences in drug resistance between drug-resistant tuberculosis patients with and without diabetes mellitus in northeast China: a retrospective study

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