Drug Sensitivity Testing for Cancer Therapy, Key Areas

Abstract

Aims: Cancer is a high-mortality disease (9.6 million deaths in 2018 worldwide). Given various anticancer drugs, drug selection plays a key role in patient survival in clinical trials. Methods: Drug Sensitivity Testing (DST), one of the leading drug selective systems, was widely practiced for therapeutic promotion in the clinic. Notably, DSTs assist in drug selection that benefits drug responses against cancer from 20-22% to 30-35% over the past two decades. The relationship between drug resistance in vitro and drug treatment benefits was associated with different tumor origins and subtypes. Medical theory and underlying DST mechanisms remain poorly understood until now. The study of the clinical scenario, sustainability and financial support for mechanism and technical promotions is indispensable Results: Despite the great technical advance, therapeutic prediction and drug selection by DST needs to be miniature, versatility and cost-effective in the clinic. Multi-parameters and automation of DST should be a future trend. Advanced biomedical knowledge and clinical approaches to translating oncologic profiles into drug selection were the main focuses of DST developments. With a great technical stride, the clinical architecture of the DST platform was entering higher levels (drug response testing at any stage of cancer patients and miniaturization of tumor samples). Discuss: The cancer biology and pharmacology for drug selection mutually benefit the clinic. New proposals to reveal more therapeutic information and drug response prediction at genetic, molecular and omics levels should be estimated overall. Conclusion: By upholding this goal of non-invasive, versatility and automation, DST could save the life of several thousand annually worldwide. In this article, new insights into DST novelty and development are highlighted.

Anti-metastatic drug development, overview and perspectives

“…[67][68][69] They are cancer biomarkers, 70 pharmacogenomics, 71 individual anti-metastatic treatment 72 and drug sensitivity testing. [73][74][75][76][77] By understanding the properties of different disciplines, we can have good drug selection in the clinic and save life of million in the future.Currently, drug sensitivity testing is mostly related with anti-metastatic therapies and drug selection. Their major techniques have been systematically progressed within the past decade.…”

“…Their major techniques have been systematically progressed within the past decade. [73][74][75] These technique progress will continue to grow in the future.…”

Bone Metastasis and Circulation Biomarkers Profiling Towards Personalized Cancer Medicine

“…Personalized medicine is a useful drug selection paradigm that may optimize drug treatment [6,7] . This includes for testing drug sensitivity, biomarkers or pharmacogenomics [10][11][12][13] .…”