Drug Targeting by Solid Lipid Nanoparticles for Dermal Use

Maia, C Santos; Mehnert, W.; Schaller, Martin; Körting, Hans Christian; Gysler, Anja; Haberland, Annekathrin; Schäfer‐Korting, Monika

doi:10.1080/1061186021000038364

Cited by 154 publications

(38 citation statements)

References 18 publications

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“…SLNs used for topical application for various drugsuch as anticancer [16], vitamin-A [17], isotretinoin, flurbiprofen [18].Using glyceryl behenate, vitamineA-loaded nanoparticles can be prepared. Thismethod is useful for the improvement ofpenetration with sustained release.…”

Section: Slns For Topical Usementioning

confidence: 99%

Solid Lipid Nanoparticle: A Review

Joshi¹

2012

iosrphr

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Section: Slns For Topical Usementioning

confidence: 99%

Solid Lipid Nanoparticle: A Review

Joshi¹

2012

iosrphr

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“…The report show an improved extent of prednicarbate uptake by human skin in vitro, if applied as SLN dispersion or cream containing prednicarbate-loaded SLN. The authors found that a prednicarbate targeting to the epidermis [189]. This is particular relevant because prednicarbate in the dermis is responsible for the induction of irreversible skin atrophy while the inflammatory process is most pronounced within the epidermis [186].…”

Section: Applications Of Nanocarrier Systems In Topical/transdermal Dmentioning

confidence: 99%

Nanocarrier Systems for Transdermal Drug Delivery

Escobar-Chávez¹,

Rodríguez-Cruz²,

Domínguez-Delgado³

et al. 2012

Recent Advances in Novel Drug Carrier Systems

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is an open discussion, in one hand, the nanotechnologist continue making new and more sophisticated nanocarriers and in the other hand, toxicologist continue evaluating possible damaging effects.Whatever it happens, nanotechnology is the new era and nanomedicine cannot be taking off. New nanocarriers will be created and the entire scientist working in nanomedicine bet for it to be the cure of diseases that in this moment are difficult to deal with [3] The application of preparations to the skin for medical purposes is as old as the history of medicine itself, with references to the use of ointments and salves found in the records of Babylonian and Egyptian medicine. The historical development of permeation research is well described by Hadgraft & Lane [4]. Over time, the skin has become an important route for drug delivery in which topical, regional or systemic effects are desired. Nevertheless, skin constitutes an excellent barrier and presents difficulties for the transdermal delivery of therapeutic agents, since few drugs possess the characteristics required to permeate across the stratum corneum in sufficient quantities to reach a therapeutic concentration in the blood. In order to enhance drug transdermal absorption different methodologies have been investigated developed and patented [5,6]. Improvement in physical permeationenhancement technologies has led to renewed interest in transdermal drug delivery. Some of these novel advanced transdermal permeation enhancement technologies include: iontophoresis, electroporation, ultrasound, microneedles to open up the skin and more recently the use of transdermal nanocarriers [3,[7][8][9][10].A number of excellent reviews that have been published contain detailed discussions concerning many aspects of transdermal nanocarriers [11][12][13][14][15][16][17]. The present chapter shows an updated overview of the use of submicron particles and other nanostructures in the pharmaceutical field, specifically in the area of topical and transdermal drugs. This focus is justified due to the magnitude of the experimental data available with the use of these nanocarriers. The development of submicron particles and other nanostructures in the pharmaceutical and cosmetic fields has been emerged in the last decades for designing best formulations for application through the skin [18][19][20][21]. The skinThe skin is the largest organ of the body [22][23][24], accounting for more than 10% of body mass, and the one that enables the body to interact more intimately with its environment. Essentially, the skin consists of four layers: The SC, that is the outer layer of the skin (nonviable epidermis), and forms the rate-controlling barrier for diffusion for almost all compounds. It is composed of dead flattened, keratin-rich cells, the corneocytes. These dense cells are surrounded by a complex mixture of intercellular lipids, namely, ceramides, free fatty acids, cholesterol, and cholesterol sulphate. Their most important feature is that they are structured as ordered bilayer arrays [25]...

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“…Besides, the drug targeting to the skin or even to its substructures could be realized by micro-and nanoparticulate systems [40,41]. These drug carrier systems could target glucocorticoids to the viable epidermis, where the inflammatory reactions take place [9]. In particular, liposomal preparations showed strong affinity for the SC [42].…”

Section: Formulations Of Tcmentioning

confidence: 99%

“…In particular, liposomal preparations showed a strong affinity for the SC. Patents filed on topical nanoparticulate formulations also claimed the importance of colloidal drug carrier systems for this type of applications [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%