Drug utilisation study in patients receiving antiepileptic drugs in Colombia

Machado‐Alba, Jorge Enrique; Calvo-Torres, L. Felipe; García-Betancur, Santiago; Aguirre-Novoa, A.; Bañol-Giraldo, Alejandra M.

doi:10.1016/j.nrleng.2015.06.002

Cited by 8 publications

(10 citation statements)

References 34 publications

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“…The differences encountered in terms of the prescription profile of pyridostigmine and other variables among the different Colombian cities in this study (Supporting Information Table ) are not surprising, given that variability in health care, particularly in prescription habits, is a persistent finding in pharmacoepidemiological studies …”

Section: Discussionmentioning

confidence: 80%

Prescription profile of pyridostigmine use in a population of patients with myasthenia gravis

et al. 2017

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We determined the pyridostigmine prescription pattern in a population of patients with myasthenia gravis (MG). A descriptive cross-sectional study was conducted by using a prescription database of 3.5 million individuals from which patients who had been diagnosed with MG and for whom pyridostigmine had been prescribed were selected. A total of 306 outpatients with MG were found, and 258 were receiving pyridostigmine (mean age 53.0 ± 18.0 years). The calculated prevalence of MG was 86.7 cases per million persons. Monotherapy was used by 53.1% of the patients, prednisolone was used by 21.7%, and 30.2% used other immunomodulators. Medications for other comorbidities were taken by 74.8% of the patients, and 43.4% had prescriptions that could potentially trigger worsening symptoms. Pyridostigmine is being prescribed at doses close to the defined daily doses predominantly as monotherapy. A high proportion of patients were also prescribed a medication that could aggravate their condition, including some that can trigger a myasthenic crisis. Muscle Nerve 56: 1041-1046, 2017.

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Section: Discussionmentioning

confidence: 80%

Prescription profile of pyridostigmine use in a population of patients with myasthenia gravis

et al. 2017

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“…Among these, 351 articles were excluded after title screening and the abstract of the 784 remaining papers was assessed. Finally, 461 publications were excluded following the eligibility criteria and thus, 323 articles that had interpretable data and fulfilled the eligibility criteria were used for data extraction…”

Section: Resultsmentioning

confidence: 99%

“…Regarding health insurance companies, a total of 27 articles reported the use of claims data as the source of data 26,27,33,44,46‐48,53,55,58,78,116,140,149,175,205,226,227,231,258,270,281,284,288,289,324,325 . In most of the articles (75%), the specific health insurance company was not identifiable.…”

Section: Resultsmentioning

confidence: 99%

Availability of secondary healthcare data for conducting pharmacoepidemiology studies in Colombia: A systematic review

Franco¹,

Vizcaya²

2020

Pharmacology Res & Perspec

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“…Monotherapy with Valproic acid (VPA) and Carbamazepine (CBZ) was commonly prescribed 11 . The study from Colombia also reported that monotherapy with conventional antiepileptics was the most widely used therapeutic approach in their population 12 . The introduction of newer AEDs to the conventional drugs brings the total number of AEDs to 20 for use in common epilepsies 13 , which indicates the possibility of 200 duo-therapies or more than 1000 combinations of 3 AEDs.…”

mentioning

confidence: 98%

“…Fortunately, potentially fatal hematological disorders such as aplastic anemia are very rare 15 . The various hematological alterations associated with older anticonvulsant drugs are aplastic anemia and agranulocytosis with Carbamazepine (CBZ)/Phenytoin (PHT) 11,12 , neutropenia and leucopenia with Phenytoin (PHT) and thrombocytopenia with Valproic acid (VPA) 16 .…”

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confidence: 99%

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2019

IJPSR

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Data Collection was through Electronic Health Record. A designed validated form to record demographic characteristics, hematological-biochemical parameters and adverse effects were utilized. Results: 115 patients were recruited. 54 (44%) were female and 64 (56%) were male. Carbamazepine; CBZ (n = 47; 40.9%) and Valproic acid; VPA (n = 32; 27.8%) were the most frequently prescribed antiepileptic drugs (AEDs). While CBZ + VPA (n = 21, 18.3%) was the most frequently prescribed combination. Generalized seizures were more frequently diagnosed (n = 80, 70%) compared to partial seizures (n = 22, 19%). The hematological abnormalities manifested as reduction in levels of Hemoglobulin (Hg), Hematocrit, Mean corpuscular volume (MCV), Mean corpuscular hemoglobin (MCH) with all AEDs, while CBZ treatment was additionally associated with reduction in Mean corpuscular hemoglobin concentration (MCHC). The combination of CBZ + VPA revealed same effect on hematological parameters except that Hematocrit was not reduced in combination therapy. Dermatitis was observed with the use of CBZ while hearing loss was observed with VPA and PHT. Conclusion: Judicious prescription of AED is required, especially when a significant proportion of patients experience hematological, CNS and other adverse effects. INTRODUCTION: Epilepsy is usually defined as a tendency to recurrent seizures. The word "epilepsy" is derived from Latin and Greek words for "seizure" or "to seize upon" 1 .

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Drug utilisation study in patients receiving antiepileptic drugs in Colombia

Cited by 8 publications

References 34 publications

Prescription profile of pyridostigmine use in a population of patients with myasthenia gravis

Prescription profile of pyridostigmine use in a population of patients with myasthenia gravis

Availability of secondary healthcare data for conducting pharmacoepidemiology studies in Colombia: A systematic review

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