DRUG UTILIZATION BASED ADRs DETECTION OF ANTIBIOTICS PRESCRIBED FOR LRTI IN TERTIARY CARE TEACHING HOSPITAL, NEW DELHI

Shamim,; Ali, Mohammad Daud; Alam, Sarfaraz; Ali, Sajid; Ahmad, Sarfaraz; Ansari, Salahuddin

doi:10.22159/ijpps.2018v10i4.23368

Cited by 3 publications

(4 citation statements)

References 10 publications

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“…Of this, amoxycillin + clavulanic acid caused most ADRs as it was the readily available antibiotic in government supply. Similar results were obtained in studies by Mandha et al [6], Shamim M et al [10] where beta lactams were the commonest antibiotic causing ADRs. NSAIDs came next with a percentage of 19 followed by bronchodilators (5.2%) and antipsychotics (3.4%).…”

Section: Discussionsupporting

confidence: 90%

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Adverse Drug Reactions in Pediatric Patients in a Tertiary Care Hospital in Kollam

Reeja

et al. 2021

Asian J Pharm Clin Res

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Objective: Adverse drug reactions have not been as thoroughly studied in children as they have in adults. Extrapolation of efficacy, dosing regimens, and ADRs from adult data are inappropriate owing to developmental changes in physiology and drug handling. There is a lack of local data regarding the potential risk of ADRs in pediatric patients. Objective of this study is to identify the adverse drug reaction (ADR) profile in pediatric patients. Methods: In this cross-sectional study, 450 children attending the pediatric inpatient and outpatient department were selected, and the CDSCO reporting form for suspected ADR reporting forms was collected from those who had any adverse events by the consulting pediatrician. Later, this form was analyzed for the details for ADRs and assessed for causality, severity, and preventability using Naranjo’s algorithm, Hartwig and Siegel scale, and modified Schumock and Thornton scale of adverse drug reactions. Results: The cross-sectional study revealed a prevalence of 12.89%. Antibiotics caused more ADRs than any other group of drugs. Dermatological ADRs were the most common. Most ADRs were not preventable and were of moderate severity. The causality assessment showed that most ADRs were possible category. Conclusion: The ADRs are often unrecognized. We need more strict monitoring for early detection, treatment, and more importantly prevention of these events in the future. For that, more awareness programs, CMEs and teamwork are extremely important among the caregivers.

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Section: Discussionsupporting

confidence: 90%

“…No severe ADRs were reported. Severe ADRs are generally not observed and are rare in recent studies also [5,6,10]. This was in accordance with study by Mandha et al and Digra et al [13].…”

Section: Discussionsupporting

confidence: 89%

Adverse Drug Reactions in Pediatric Patients in a Tertiary Care Hospital in Kollam

Reeja

et al. 2021

Asian J Pharm Clin Res

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“…Whereas, according to the WHO, it is stated that the use of ceftriaxone to achieve optimal therapy was 10-14 days [8], for example, for giving too short of administration of antibiotics ceftriaxone 2 times a day with a dose of 225 mg in patients having body weight 9 kg and given only for 2 days. In Indonesia, the use of antibiotics is in the range of 3-7 days to kill disease-causing microbes [7,21]. If the treatment was done too short, the therapy will not be optimal and in the long run which will cause the resistance of antibiotics.…”

Section: Discussionmentioning

confidence: 99%

The Rationality of Antibiotics Therapy Toward Children With Typhoid Fever at M.M. Dunda Hospital

Tuloli

Moo

2018

Asian J Pharm Clin Res

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Objectives: Typhoid fever is an acute systemic infectious disease in the small intestine caused by Salmonella enterica serotype typhi (Salmonella typhi) having the symptoms of fever a week or more with impairment of the gastrointestinal tract with or without impaired consciousness. The purpose of this study was to determine the rationality of antibiotic therapy in pediatric patients at M.M Dunda Limboto Hospital.Methods: This research belongs to non-experimental descriptive with retrospective data retrieval. The data used were obtained from 83 medical records of childhood typhoid patients during 6 months (June–November 2016) at the regional general hospital of M.M Dunda Limboto. These data were analyzed using the Gyssens criteria.Results: The results showed that the most antibiotics used by physicians were ceftriaxone 39% of the use of antibiotic quality which was category IIB 9%, category IIA 13%, and category 0 (rational) 52%.Conclusion: The rationality of antibiotic therapy in children with typhoid fever at M.M Dunda Limboto Hospital was 52% of the most antibiotics used, i.e. ceftriaxone (39%).

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“…Exposure of variable individuals to infectious agents, infectious dose and pathogen virulence drive differences in the frequency of respiratory infections. The rating of infectious disease risk depends on several environmental factors and lifestyle habits 5 . Infectious respiratory diseases include common cold, bronchitis, bronchiolitis, pneumonia, tuberculosis whereas non infectious respiratory diseases include chronic obstructive pulmonary disease, asthma, occupational lung disease and pulmonary malignancies.…”

Section: Introductionmentioning

confidence: 99%

A Study on Drug Utilization of Antibiotics in Respiratory Tract Infections among Geriartrics

Charave

Suresh

Shihab

et al. 2020

J. Drug Delivery Ther.

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Back ground: Respiratory Tract Infections (RTIs) often pose a major threat for geriatric patients (>60 years) who are at higher risk of developing complications. The first line treatments for RTIs are antibiotics which help in reducing the infection. As there is increasing incidence of antimicrobial resistance it is necessary to conduct drug utilization of antibiotics which helps in better understanding about errors and risks involved in prescriptions. Objectives: The objective of the study is to access the prescribing pattern, appropriate use of antibiotics and inappropriateness of antibiotics in viral infections. Methodology: The present study is a prospective observational study. The study included 110 patients which included the evaluation of the patients medical records of antibiotics, sputum culture reports and physician records. Results: Out of 110 geriartric RTI patients, female (59.09%) were more predominantly affected over males (40.90%). Among the RTIs diagnosed pneumonia (40%) was higher followed by LRTI (28.18%). The common signs and symptoms found were breathlessness (34.54%) with major comorbidity of diabetes milletus (47.31%). Piperacillin + tazobactam (40.90%) was the mostly prescribed antibiotic for both gram positive (Streptococci) and gram negative (E. coli) bacteria which was given through I.V. (90%). Total drug interactions and medication errors were 13.03% and 3.32% respectively. Conclusion: The present study gives an overview of antibiotics use and complications involved in geriatric population diagnosed with RTIs. Appropriate antibiotic usage according to Hospital Antibiotic Policy was observed in the study site with lower number of medication errors and drug interactions. Key words: Respiratory Tract Infections, drug utilization, antibiotics, geriatrics.

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DRUG UTILIZATION BASED ADRs DETECTION OF ANTIBIOTICS PRESCRIBED FOR LRTI IN TERTIARY CARE TEACHING HOSPITAL, NEW DELHI

Cited by 3 publications

References 10 publications

Adverse Drug Reactions in Pediatric Patients in a Tertiary Care Hospital in Kollam

Adverse Drug Reactions in Pediatric Patients in a Tertiary Care Hospital in Kollam

The Rationality of Antibiotics Therapy Toward Children With Typhoid Fever at M.M. Dunda Hospital

A Study on Drug Utilization of Antibiotics in Respiratory Tract Infections among Geriartrics

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