Drug utilization study in pediatric prescriptions of a university hospital in southern brazil: off-label, unlicensed and high-alert medications

Santos, Luciana dos; Heineck, Isabela

doi:10.1016/j.farma.2010.12.008

Cited by 45 publications

(45 citation statements)

References 24 publications

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“…Observing the profile of oral solutions and suspensions compounded for newborns and children of the studied hospital, it was verified that solutions/suspensions of these active principles were identified in other studies: folic acid,9 , 19 folinic acid,9 , 20 ursodeoxycholic acid,11 , 14 captopril,8 , 9 , 14 , 15 , 18 , 21 caffeine,12 , 16 , 19 , 22 , 23 spironolactone,9 , 24 - 28 fluconazole,17 furosemide,8 , 9 , 26 hydrochlorothiazide,8 , 9 , 18 , 26 , 27 propranolol,10 ranitidine,9 pyrimethamine17 and sulfadiazine 17. Therefore, it is observed that the demand for oral solutions and suspensions administered to newborns and children in this study has also been observed in other studies and that the compounding of drugs is a national and international necessity due to the lack of oral liquid drugs from the pharmaceutical industry.…”

Section: Discussionsupporting

confidence: 63%

“…, 8 Costa et al found 119 drug adaptations from solid to liquid form and Gavrilov et al identified two dose modifications in pharmaceutical forms 910 Dos Santos and Heineck found that 79 prescription items involved extemporaneous preparations 11. Extemporaneous compounded oral preparations are magistral drugs that should be used within 48hours 3…”

Section: Discussionmentioning

confidence: 99%

“…In Brazil, there are few studies on the use of magistral drugs in infants and children, which are concentrated in hospitals from only three Brazilian cities: Fortaleza,9 , 14 , 15 Porto Alegre11 , 16 and Belo Horizonte 1718 …”

Section: Discussionmentioning

confidence: 99%

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Magistral drugs in hospitalized newborns and children

Pereira

Miranda

Castilho

et al. 2016

Revista Paulista de Pediatria (English Edition)

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Objective:Study the use of magistral oral solutions and suspensions in infants and children at a university hospital.Methods:This is a descriptive study based on the analysis of the assessed hospital's magistral drug request forms regarding the patients in the neonatal ICU, Obstetrics, Pediatrics and Pediatric Emergency from January 2012 to December 2013. The frequency of drug requests and dispensation was evaluated and the consumption of each active ingredient of the preparations was expressed as number of “infant defined daily dose” (iDDD) and of iDDD/100 bed-days.Results:A total of 657 forms were analyzed - a monthly average of 27 pediatric preparations. The neonatal ICU accounted for 69.6% of these requests. Twenty-one drug items were used, of which the most common were folinic acid (88 requests), sulfadiazine (85) and captopril (73). The consumption of the active principle in these preparations varied in number of iDDD, from 7.5 (hydralazine) to 16,520.0 (folic acid), and in number of iDDD/100 bed-days in the neonatal ICU, from 0.1 (zinc sulfate) to 146.1 (folic acid).Conclusions:The constant consumption of magistral oral solutions and suspensions by newborns and children of the assessed hospital indicates the need for such preparations as a pediatric therapeutic alternative in this hospital.

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Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

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Magistral drugs in hospitalized newborns and children

Pereira

Miranda

Castilho

et al. 2016

Revista Paulista de Pediatria (English Edition)

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“…The studies were conducted in 18 countries spread across four continents, principally Europe (55.9 %) [19-23, 25, 28-30, 32, 35, 37-39, 41, 43, 44, 48, 49], followed by America (23.5 %) [27,31,34,40,45,47,50,52], Asia (11.8 %) [24,33,36,42,46] and Oceania (5.9 %) [26,51]. The country with most studies was Brazil (14.7 %) [27,34,45,47,50].…”

Section: Characteristics Of Selected Studiesmentioning

confidence: 99%

Use of off-label and unlicenced drugs in hospitalised paediatric patients: a systematic review

Magalhães

Rodrigues

Roque

et al. 2014

Eur J Clin Pharmacol

103

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These findings show that: (i) off-label and/or an unlicensed prescribing is widespread among the hospitalised paediatric population worldwide, (ii) there is no consensus on a definition of off-label and/or unlicensed drugs and (iii) preterm newborns receive most off-label and/or unlicensed drugs. By shedding new light on off-label and/or unlicensed drug prescribing, these findings will hopefully contribute to generating new, more effective knowledge about the paediatric population's need for quality drugs that are both safe and efficacious.

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“…Quando avaliadas as classes ATC, verificou-se que a mais prescrita incluiu os medicamentos para o sistema nervoso, seguida de anti-infecciosos sistêmicos e dos medicamentos para trato digestivo e metabólico; e comparativamente a outros estudos, verificou-se uma semelhança nas classes mais utilizadas [10,[44][45][46]. Os anti-infecciosos sistêmicos aparecem na lista dos medicamentos mais utilizados por crianças em diversos estudos [47,48], e este é um resultado esperado ao considerar-se que as doenças infecciosas, especialmente as de vias respiratórias, estão entre as morbidades mais comuns em crianças, sendo responsáveis por grande parte das prescrições de antimicrobianos [49].…”

Section: Artigo Originalunclassified

Utilização de medicamentos em crianças internadas em um hospital geral

Martins

Uberti

Warpechowski

et al. 2017

Sci Med

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*** Medication use in children admitted to a general hospital ***AIMS: To describe the profile of medications used in children admitted to a general hospital.METHODS: A cross-sectional study was conducted with children aged 0 to 12 years, admitted to the Hospital Nossa Senhora da Conceição, in Tubarão, state of Santa Catarina, Brazil, between July 2013 and July 2014. The following data were collected: f age, sex, length of hospital stay, International Classification of Diseases codes for hospitalization, and medications used. The Anatomical Therapeutic Chemical classification system was used for the medications.RESULTS: The medical records of 1,603 children aged up to 12 years were analyzed. The hospital stay ranged from one to 115 days. The number of medications per admission ranged from one to 77, with an average of 9.84 medications per patient. A total of 211 different types of medications were used, most of which were classified as analgesic with central nervous system activity. Tonsillar hypertrophy and adenoid hypertrophy were the most prevalent disorders diagnosed among the 303 different International Classification of Diseases codes found in this study. Seven types of unlicensed medications and 23 drugs with some kind of restriction for pediatric use were prescribed.CONCLUSIONS: The average number of medications was high in hospitalized children, and the prescription of unlicensed drugs and those with some kind of restriction for pediatric use was an important factor. These data suggest poor attention to the risks and benefits of medication use in children – a relevant issue that requires continuous and intensive surveillance by different health professionals .

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Drug utilization study in pediatric prescriptions of a university hospital in southern brazil: off-label, unlicensed and high-alert medications

Cited by 45 publications

References 24 publications

Magistral drugs in hospitalized newborns and children

Magistral drugs in hospitalized newborns and children

Use of off-label and unlicenced drugs in hospitalised paediatric patients: a systematic review

Utilização de medicamentos em crianças internadas em um hospital geral

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