Drug Vectoring Systems to Target Drug Delivery Using Nanotechnologies

Pérez-Surio, Alberto Frutos; Alcacera-Lopez, M. Aranzazu

doi:10.2174/2468187307666170712151006

Cited by 3 publications

(2 citation statements)

References 24 publications

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“…This internalization was observed with liposomes decorated with glycyrrhizic acid due to the presence of GL receptors on the surface of rat hepatocytes [67]. The increasing evolution of the molecular biology knowledge and the consequent discovery of new targets and promising target ligands provides new information for the development of new nanosystems decorated for vectorization [68][69][70].…”

Section: Vectorization Of Nanosystemsmentioning

confidence: 93%

Glycyrrhizic Acid and Its Hydrolyzed Metabolite 18β-Glycyrrhetinic Acid as Specific Ligands for Targeting Nanosystems in the Treatment of Liver Cancer

et al. 2021

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Glycyrrhizic acid and its hydrolyzed metabolite 18β-glycyrrhetinic acid, obtained from the plant Glycyrrhiza glabra, have numerous pharmacological activities, such as anti-inflammatory, anti-ulcerative, antiallergic, immunomodulatory, antiviral, antitumor, hepatoprotective, and antioxidant effects, and others. In addition to the pharmacological activities, in the 1980s, an interaction and uptake of these molecules by the liver was verified, which was later confirmed by other studies through the discovery of specific receptors in the hepatocytes. The presence of these specific receptors in the liver led to vectorization and delivery of drugs, by the introduction of glycyrrhizic acid or glycyrrhetinic acid on the surface of nanosystems, for the treatment of liver diseases. This review describes experimental evidence of vectorization by conjugating glycyrrhizic acid or glycyrrhetinic acid to nanosystems and delivery of antitumor drugs for the treatment of liver cancer and also describes the techniques used to perform this conjugation. We have shown that due to the existence of specific receptors for these molecules, in addition to the targeting of nanosystems to hepatocytes, nanosystems having glycyrrhizic acid or glycyrrhetinic acid on their surface had the same therapeutic effect in a significantly lower dose compared to the free drug and unconjugated nanosystems, with consequent reduction of side effects and toxicity.

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Section: Vectorization Of Nanosystemsmentioning

confidence: 93%

Glycyrrhizic Acid and Its Hydrolyzed Metabolite 18β-Glycyrrhetinic Acid as Specific Ligands for Targeting Nanosystems in the Treatment of Liver Cancer

et al. 2021

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“…The vectorization of active molecules is currently a major challenge in many research fields such as pharmaceuticals, food and cosmetics. In the pharmaceutical field, synthetic or bio-inspired nanocarriers are mainly developed to specifically deliver drugs such as anti-cancer agents [1][2][3][4][5] or therapeutic proteins [6]. In this area, genetically engineered organic, inorganic and virus-like nanostructures [7] or nanocarriers synthetized from ionic liquids [8] have increasing interest compared with conventional drug delivery systems.…”

Section: Introductionmentioning

confidence: 99%

Encapsulation of Vitamin C by Glycerol-Derived Dendrimers, Their Interaction with Biomimetic Models of Stratum corneum and Their Cytotoxicity

et al. 2022

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Vitamin C is one of the most sensitive cosmetic active ingredients. To avoid its degradation, its encapsulation into biobased carriers such as dendrimers is one alternative of interest. In this work, we wanted to evaluate the potential of two biobased glycerodendrimer families (GlyceroDendrimers-Poly(AmidoAmine) (GD-PAMAMs) or GlyceroDendrimers-Poly(Propylene Imine) (GD-PPIs)) as a vitamin C carrier for topical application. The higher encapsulation capacity of GD-PAMAM-3 compared to commercial PAMAM-3 and different GD-PPIs, and its absence of cytotoxicity towards dermal cells, make it a good candidate. Investigation of its mechanism of action was done by using two kinds of biomimetic models of stratum corneum (SC), lipid monolayers and liposomes. GD-PAMAM-3 and VitC@GD-PAMAM-3 (GD-PAMAM-3 with encapsulated vitamin C) can both interact with the lipid representatives of the SC lipid matrix, whichever pH is considered. However, only pH 5.0 is suggested to be favorable to release vitamin C into the SC matrix. Their binding to SC-biomimetic liposomes revealed only a slight effect on membrane permeability in accordance with the absence of cytotoxicity but an increase in membrane rigidity, suggesting a reinforcement of the SC barrier property. Globally, our results suggest that the dendrimer GD-PAMAM-3 could be an efficient carrier for cosmetic applications.

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Folic acid modified precision nanocarriers: charting new frontiers in breast cancer management beyond conventional therapies

Nehal,

Rohilla,

Sartaj

et al. 2024

Journal of Drug Targeting

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Drug Vectoring Systems to Target Drug Delivery Using Nanotechnologies

Cited by 3 publications

References 24 publications

Glycyrrhizic Acid and Its Hydrolyzed Metabolite 18β-Glycyrrhetinic Acid as Specific Ligands for Targeting Nanosystems in the Treatment of Liver Cancer

Glycyrrhizic Acid and Its Hydrolyzed Metabolite 18β-Glycyrrhetinic Acid as Specific Ligands for Targeting Nanosystems in the Treatment of Liver Cancer

Encapsulation of Vitamin C by Glycerol-Derived Dendrimers, Their Interaction with Biomimetic Models of Stratum corneum and Their Cytotoxicity

Folic acid modified precision nanocarriers: charting new frontiers in breast cancer management beyond conventional therapies

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