Drugs for Treating Respiratory System Diseases

Vardanyan, Ruben; Hruby, Victor

doi:10.1016/b978-0-12-411492-0.00023-7

Cited by 5 publications

(1 citation statement)

References 91 publications

(67 reference statements)

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“…Theophylline, a dimethylxanthine, is considered one of the most widely prescribed drugs to treat obstructive pulmonary diseases [1]. The structure is very related to caffeine [2], and theophylline occurs in coffee beans, cocoa beans and tea, although only in trace amounts. Henry Hyde Salter, MD, FRCP, wrote in his report from 1859, that "One of the commonest and best-reputed remedies of asthma, one that is almost sure to have been tried in any case that may come under our observation, and one that in many cases is more efficacious than any other, is strong coffee" [3].…”

Section: Introductionmentioning

confidence: 99%

Nationwide use of theophylline among adults-A 20-year Danish drug utilisation study

Henriksen

Davidsen

Laursen

2018

Respiratory Medicine

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Section: Introductionmentioning

confidence: 99%

Nationwide use of theophylline among adults-A 20-year Danish drug utilisation study

Henriksen

Davidsen

Laursen

2018

Respiratory Medicine

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Access to N−CF₃ Formamides by Reduction of N−CF₃ Carbamoyl Fluorides

2022

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The departure into unknown chemical space is essential for the discovery of new properties and function. We herein report the first synthetic access to N‐trifluoromethylated formamides. The method involves the reduction of bench‐stable NCF3 carbamoyl fluorides and is characterized by operational simplicity and mildness, tolerating a broad range of functional groups as well as stereocenters. The newly made N−CF3 formamide motif proved to be highly robust and compatible with diverse chemical transformations, underscoring its potential as building block in complex functional molecules.

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Access to N−CF₃ Formamides by Reduction of N−CF₃ Carbamoyl Fluorides

2022

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The departure into unknown chemical space is essential for the discovery of new properties and function. We herein report the first synthetic access to N-trifluoromethylated formamides. The method involves the reduction of bench-stable NCF 3 carbamoyl fluorides and is characterized by operational simplicity and mildness, tolerating a broad range of functional groups as well as stereocenters. The newly made NÀ CF 3 formamide motif proved to be highly robust and compatible with diverse chemical transformations, underscoring its potential as building block in complex functional molecules.

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Drugs for Treating Respiratory System Diseases

Cited by 5 publications

References 91 publications

Nationwide use of theophylline among adults-A 20-year Danish drug utilisation study

Nationwide use of theophylline among adults-A 20-year Danish drug utilisation study

Access to N−CF₃ Formamides by Reduction of N−CF₃ Carbamoyl Fluorides

Access to N−CF₃ Formamides by Reduction of N−CF₃ Carbamoyl Fluorides

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Drugs for Treating Respiratory System Diseases

Cited by 5 publications

References 91 publications

Nationwide use of theophylline among adults-A 20-year Danish drug utilisation study

Nationwide use of theophylline among adults-A 20-year Danish drug utilisation study

Access to N−CF3 Formamides by Reduction of N−CF3 Carbamoyl Fluorides

Access to N−CF3 Formamides by Reduction of N−CF3 Carbamoyl Fluorides

Contact Info

Product

Resources

About

Access to N−CF₃ Formamides by Reduction of N−CF₃ Carbamoyl Fluorides

Access to N−CF₃ Formamides by Reduction of N−CF₃ Carbamoyl Fluorides