Drusen ooze: Predictor for progression of dry age-related macular degeneration

Jhingan, Mahima; Singh, Sumit Randhir; Samanta, Anindya; Arora, Supriya; Tucci, Davide; Amarasekera, Sohani; Cagini, Carlo; Lupidi, Marco; Chhablani, Jay

doi:10.1007/s00417-021-05147-7

Cited by 13 publications

(14 citation statements)

References 20 publications

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“…The residual bodies of the disc membrane remain and deposit on Bruch's membrane, forming drusen and leading to macular degeneration. 5 Upon Bruch's membrane rupture, choroidal capillaries migrate through the ruptured Bruch's membrane into the RPE and subcutaneous space of retinal nerve, forming choroidal neovascularization (CNV, Figure 1). 6 Dry AMD, also named non-neovascular, non-exudative or atrophic AMD, is characterized by the development of drusen, 7 while wet AMD, also known as neovascular or exudative AMD, is characterized by CNV.…”

Section: Introductionmentioning

confidence: 99%

Long-Chain Polyunsaturated Fatty Acids and Their Metabolites Regulate Inflammation in Age-Related Macular Degeneration

Ren¹,

Ren²,

Deng³

et al. 2022

JIR

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Age-related macular degeneration (AMD) is a blinding eye disease, whose incidence strongly increases with ages. The etiology of AMD is complex, including aging, abnormal lipid metabolism, chronic inflammation and oxidative stress. Long-chain polyunsaturated fatty acids (LCPUFA) are essential for ocular structures and functions. This review summarizes the regulatory effects of LCPUFA on inflammation in AMD. LCPUFA are related to aging, autophagy and chronic inflammation. They are metabolized to pro-and anti-inflammatory metabolites by various enzymes. These metabolites stimulate inflammation in response to oxidative stress, causing innate and acquired immune responses. This review also discusses the possible clinical applications, which provided novel targets for the prevention and treatment of AMD and other age-related diseases.

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Section: Introductionmentioning

confidence: 99%

Long-Chain Polyunsaturated Fatty Acids and Their Metabolites Regulate Inflammation in Age-Related Macular Degeneration

Ren¹,

Ren²,

Deng³

et al. 2022

JIR

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“…5 More recently, drusen ooze was defined by Jhingen et al as an inclusive term that includes both isoreflective dots at the level of the retina pigment epithelium and hyperreflective dots overlying a drusen with underlying collapsing drusen or pseudodrusen. 6 The odds of progression to iRORA or cRORA was 20.3 times greater for eyes with drusen ooze at baseline. 6 So far, the studies have reported the progression of the disease or these biomarkers in one eye.…”

Section: Introductionmentioning

confidence: 92%

Bilateral evolution of OCT biomarkers in dry AMD: Long-term follow up study

Samanta,

Arora,

Jhingan

et al. 2023

European Journal of Ophthalmology

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Purpose To report the emergence and progress of four late-stage characteristics: incomplete retinal pigment epithelium and outer retinal atrophy (iRORA) and complete RPE and outer retinal atrophy (cRORA), drusen ooze and drusen collapse in eyes with dry age-related macular degeneration (AMD) using Spectral Domain Optical Coherence Tomography (SD-OCT). Methods This was a retrospective analysis of eyes with non-exudative AMD. Multimodal imaging was done at follow up visits ≤ 12 months. OCT volume scan was used to assess and identify the 4 characteristics. Univariate analysis was done for the various demographic and clinical characteristics. Patients with a mean age of 76.7 ± 10 years were followed up for 69.9 ± 20.6 months. iRORA, cRORA, drusen ooze was present in 15.6%, 15.6% and 15.6% of patients at baseline, respectively, and 25.0%, 40.6% and 53.1% of patients at the final follow-up, respectively. At baseline 9.1%, 0% and 9.1% of patients had bilateral drusen ooze, iRORA and cRORA, respectively. By the final follow-up, drusen collapse occurred in 46.9% and 18.8% patients in unilateral and bilateral eyes, respectively. For bilateral cases, the mean interval of time between emergence inthe two eyes for drusen ooze, drusen collapse, iRORA, and cRORA was 5 ± 1.4 years, 2.2 ± 2.2 years, 3.5 ± 0.7 and 1.7 ± 0.6 years, respectively. Conclusions Late-stage OCT biomarkers are seen bilaterally at 21.9% at baseline and at 56.3% at 5.8 years follow-up. Once present in one eye, cRORA had the shortest mean interval before appearance in the other eye.

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“…60 Eyes with drusen ooze had 20.3 odds of developing iRORA or cRORA at 2 years. 61,62 SDD or reticular pseudodrusen are discrete hyperreflective material located above the RPE and the ellipsoid zone (EZ). 63 Defined staging by Zweifel et al 64 shows SDD progressively getting larger and eventually breaking through the EZ.…”

Section: Optical Coherence Tomographymentioning

confidence: 99%

“… 60 Drusen ooze was defined as isoreflective dots that emerge from the top of a drusen through the defects of the RPE, often accompanied by hyperreflective dots and drusen collapse 60 . Eyes with drusen ooze had 20.3 odds of developing iRORA or cRORA at 2 years 61,62 …”

Section: Introductionmentioning

confidence: 99%

Imaging Modalities for Dry Macular Degeneration

Samanta,

Alsoudi,

Rahimy

et al. 2023

International Ophthalmology Clinics

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Drusen ooze: Predictor for progression of dry age-related macular degeneration

Cited by 13 publications

References 20 publications

Long-Chain Polyunsaturated Fatty Acids and Their Metabolites Regulate Inflammation in Age-Related Macular Degeneration

Long-Chain Polyunsaturated Fatty Acids and Their Metabolites Regulate Inflammation in Age-Related Macular Degeneration

Bilateral evolution of OCT biomarkers in dry AMD: Long-term follow up study

Imaging Modalities for Dry Macular Degeneration

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