Dry eye diagnosis and management

Módis, László; Szalai, Eszter

doi:10.1586/eop.10.89

Cited by 16 publications

(16 citation statements)

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“…The TBUT test for TBUT was performed in accordance with standard procedures. Results of the TBUT samples were evaluated as follows: 10 s or more = normal [20], 5–9 s = mild level of TBUT dysfunction, 3–4 s = moderate, <3 s = severe [5, 6]. Corneal staining was performed using fluorescein strips, with the cornea divided into five zones: central, superior, inferior, nasal, and temporal.…”

Section: Methodsmentioning

confidence: 99%

Results of a Multicenter, Randomized, Double-Masked, Placebo-Controlled Clinical Study of the Efficacy and Safety of Visomitin Eye Drops in Patients with Dry Eye Syndrome

et al. 2015

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IntroductionThis article presents the results of an international, multicenter, randomized, double-masked, placebo-controlled clinical study of Visomitin (Mitotech LLC, Moscow, Russian Federation) eye drops in patients with dry eye syndrome (DES). Visomitin is the first registered (in Russia) drug with a mitochondria-targeted antioxidant (SkQ1) as the active ingredient.MethodsIn this multicenter (10 sites) study of 240 subjects with DES, study drug (Visomitin or placebo) was self-administered three times daily (TID) for 6 weeks, followed by a 6-week follow-up period. Seven in-office study visits occurred every 2 weeks during both the treatment and follow-up periods. Efficacy measures included Schirmer’s test, tear break-up time, fluorescein staining, meniscus height, and visual acuity. Safety measures included adverse events, slit lamp biomicroscopy, tonometry, blood pressure, and heart rate. Tolerability was also evaluated.ResultsThis clinical study showed the effectiveness of Visomitin eye drops in the treatment of signs and symptoms of DES compared with placebo. The study showed that a 6-week course of TID topical instillation of Visomitin significantly improved the functional state of the cornea; Visomitin increased tear film stability and reduced corneal damage. Significant reduction of dry eye symptoms (such as dryness, burning, grittiness, and blurred vision) was also observed.ConclusionBased on the results of this study, Visomitin is effective and safe for use in eye patients with DES for protection from corneal damage.FundingMitotech LLC.

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Section: Methodsmentioning

confidence: 99%

Results of a Multicenter, Randomized, Double-Masked, Placebo-Controlled Clinical Study of the Efficacy and Safety of Visomitin Eye Drops in Patients with Dry Eye Syndrome

et al. 2015

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“…In severe forms of the disease, conjunctival scarring or conjunctivochalasis and/or corneal complications may occur. Filamentary keratitis, persistent epithelial defects, ulceration, and even corneal perforation can complicate the course [14,15,22]. Corneal staining may be required to evaluate the severity of its defects.…”

Section: Slit-lamp Biomicroscopymentioning

confidence: 99%

“…The result is recorded after 5 minutes. Normally, the length of wetted strip is around 10 mm or greater and if the length is less than 5 mm, it indicates symptomatic tear deficient; but Schirmer's test values less or equal to 10 mm have greater diagnostic value and indicate hyposecretion [22,[46][47][48][49][50].…”

Section: Schirmer's Testmentioning

confidence: 99%

“…Table 4 helps the clinician to grade the severity of the DED. Despite the wide use in clinical practice, standard tests for assessing DED and ocular surface disorders (including history taking and symptoms recording, TBUT, meibomian gland testing, ocular surface saining, and Schirmer's testing) have shown poor repeatability and lack of efficacy [22,57]. Moreover, it is well know that subjective symptoms often do not correlate with objective signs.…”

Section: Assessing the Dry Eyementioning

confidence: 99%

“…Adapted from Módis and Szalai [22]. that is not identified as dry eye (such as fluctuating vision) but do not show a lot of ocular finding such as corneal staining or any other marked conditions.…”

Section: Assessing the Dry Eyementioning

confidence: 99%

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Examination for Dry Eyes

Wahyu¹

2022

Dry Eye Syndrome - Modern Diagnostic Techniques and Advanced Treatments

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Dry eye disease (DED) is a multifactorial disease of tears and ocular surface that results in various symptoms with the potential damage to the ocular surface. It can range from mild to severe signs and symptoms and may affect patient’s quality of life. Various techniques and methods have been developed to evaluate DED for initial examination or regular follow up. The simple evaluations that can be performed in clinic include eyelid examination, tear break-up time, and ocular surface stainings; while the advanced ones may require certain devices or laboratory equipment. Careful and thorough examinations are important to guide the clinician to assess and evaluate dry eye.

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