Dry Eye Management: Targeting the Ocular Surface Microenvironment

Zhang, Xiaobo; M, Vimalin Jeyalatha; Qu, Yangluowa; He, Xin; Ou, Shangkun; Bu, Jinghua; Jia, Changkai; Wang, Junqi; Wu, Han; Liu, Zuguo; Li, Wei

doi:10.3390/ijms18071398

Cited by 195 publications

(212 citation statements)

References 198 publications

(232 reference statements)

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“…Sex hormones are known to play a role in the maintenance of the structure and integrity of the human cornea (Zhang et al, 2017). Corneal thickness, curvature, and sensitivity were altered throughout the menstrual cycle (Ghahfarokhi et al, 2015).…”

Section: Prolactin Induced Proteinmentioning

confidence: 99%

Pathogenesis of Keratoconus: The intriguing therapeutic potential of Prolactin-inducible protein

Sharif

Bak‐Nielsen

Hjortdal

et al. 2018

Progress in Retinal and Eye Research

103

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Keratoconus (KC) is the most common ectatic corneal disease, with clinical findings that include discomfort, visual disturbance and possible blindness if left untreated. KC affects approximately 1:400 to 1:2000 people worldwide, including both males and females. The aetiology and onset of KC remains a puzzle and as a result, the ability to treat or reverse the disease is hampered. Sex hormones are known to play a role in the maintenance of the structure and integrity of the human cornea. Hormone levels have been reported to alter corneal thickness, curvature, and sensitivity during different times of menstrual cycle. Surprisingly, the role of sex hormones in corneal diseases and KC has been largely neglected. Prolactin-induced protein, known to be regulated by sex hormones, is a new KC biomarker that has been recently proposed. Studies herein discuss the role of sex hormones as a control mechanism for KC onset and progression and evidence supporting the view that prolactin-induced protein is an important hormonally regulated biomarker in KC is discussed.

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Section: Prolactin Induced Proteinmentioning

confidence: 99%

Pathogenesis of Keratoconus: The intriguing therapeutic potential of Prolactin-inducible protein

Sharif

Bak‐Nielsen

Hjortdal

et al. 2018

Progress in Retinal and Eye Research

103

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“…The mean weights of the samples of all formulae were ranged between (16.23±1.39 mg -20.30±0.92 mg) as shown in table (5).…”

Section: Weight Uniformitymentioning

confidence: 98%

“…The prepared inserts of all formulae had drug content means ranged between (1.84±0.14 mg -2.16±0.17 mg); the results are presented in table (5). According to USP dosage uniformity criteria the acceptable range would be (1.7mg -2.3 mg).…”

Section: Drug Content Uniformitymentioning

confidence: 99%

“…The results of folding endurance are shown in table (5). F1 was very brittle due to the absence of the plasticizer in its composition, which ensures the importance of the plasticizer presence in formulating the inserts.…”

Section: Folding Endurancementioning

confidence: 99%

“…Dry eye management includes patient's education, dietary and environmental changes, artificial tears, punctal plugs, topical and systemic medications; in addition to surgical intervention which can be a possible option. The choice of a suitable management is based on the etiology and severity of the syndrome (4,1,5) .…”

Section: Introductionmentioning

confidence: 99%

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Preparation and Evaluation of Rebamipide Film using Casting Technique for Local Action

Radhi

Ghareeb

2019

IJPS

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The aim of this study is to prepare and evaluate an extended release rebamipide ocular insert using hydroxypropyl methylcellulose as the main components of this drug delivery system for dry eye syndrome management, to have the advantage of both rebamipide inducing mucin secretion and hydroxypropyl methylcellulose lubricating properties. Solvent casting technique was used to prepare the inserts; the amino acid L-arginine was used to solubilize the drug, hydroxypropyl methylcellulose grades (HPMC E5 and K15M) and poly ethylene glycol 200 were used as excipients. The inserts were evaluated for their physical and mechanical properties, moisture loss% and absorption %, surface pH, and in-vitro drug release. The use of L-arginine exhibited an enhancement of rebamipide solubility in both deionized water and phosphate buffer (pH 7.4) by approximately 274 and 2.8 folds, respectively. The formulae showed uniform weight, thickness and drug content except for formula (F1) that composed mostly of HPMC E5: HPMC K15M at ratio of 1: 0.17 and had no plasticizer (poly ethylene glycol 200) in its composition; it showed haziness in its appearance and brittleness of the insert. While formula (F3) which contained mainly HPMC E5: HPMC K15M at ratio of 1: 0.4 with poly ethylene glycol 200 showed good physical and mechanical properties thus was selected for in vitro release and was compared to the marketed brand Mucosta ® ophthalmic suspension unit dose 2%w/v; F3 showed significant larger T50% and T80% (p-values 0.034 and 0.015) compared to those of the reference marketed brand and similarity factor value was (f2 = 37.27). The results of this study showed that rebamipide ocular inserts have good potential for futuristic rebamipide extended release ocular delivery system.

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Quantitative Proteomics and Weighted Correlation Network Analysis of Tear Samples in Type 2 Diabetes Patients Complicated with Dry Eye

Zou

Zhang

et al. 2020

Proteomics Clinical Apps

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PurposeDiabetic patients are more likely to experience dry eye (DE). TMT‐based proteomics and WGCNA are used to identify the differentially expressed proteins in tear proteome of type 2 diabetes with DE. The aim is to provide a molecular basis for exploring possible mechanisms underlying the pathogenesis of diabetic DE.Experimental designSubjects are divided into four groups (ten in each): type 2 diabetes with DE; type 2 diabetes without DE; non‐diabetes with DE and normal controls. All subjects undergo DE tests. Total proteins are extracted and quantitatively labeled with TMT, then analyzed using liquid chromatography‐mass spectrometry. WGCNA is used to identify the hub genes. Finally, differentially expressed proteins are validated by ELISA.ResultsA total of 1922 proteins are identified, of which 1814 contain quantitative information. Ultimately, 650 of these proteins yield quantitative values. WGCNA performed on these 650 proteins reveal four distinct hub genes of diabetic DE.Conclusions and clinical relevanceDE is associated with the differential expression of tear proteins in type 2 diabetes. Inflammation, immune factors, and lipid metabolism may play a role in the development of diabetic DE. LTF, LYZ, ZAG, and DNAJC3 have the potential to be the biomarkers of DE in diabetes.

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Dry Eye Management: Targeting the Ocular Surface Microenvironment

Cited by 195 publications

References 198 publications

Pathogenesis of Keratoconus: The intriguing therapeutic potential of Prolactin-inducible protein

Pathogenesis of Keratoconus: The intriguing therapeutic potential of Prolactin-inducible protein

Preparation and Evaluation of Rebamipide Film using Casting Technique for Local Action

Quantitative Proteomics and Weighted Correlation Network Analysis of Tear Samples in Type 2 Diabetes Patients Complicated with Dry Eye

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