Dry, Moist, and Wet Skin Wound Repair

Vogt, Peter M.; Andree, Christoph; Breuing, Karl H.; Liu, Paul Y.; Sláma, Jaromír; Helo, Giselle; Eriksson, Elof

doi:10.1097/00000637-199505000-00007

Cited by 158 publications

(103 citation statements)

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“…When a wound bed dries, a crust is formed and promotes the migration of the cells to a deeper and humid level in the wound. Vogt 56 observed the wound healing favored by a humid environment (wounds treated with hydrocolloid dressing) was significantly faster in comparison to dry wounds (wounds treated with sterile gauze). In fact, the BC-COL hydrogel and collagenase ointment used favored a humid environment for the wound bed and promoted an earlier and better tissue repair in relation to the dry wound (control group).…”

Section: In Vivo Experimentsmentioning

confidence: 99%

Bacterial Cellulose/Collagen Hydrogel for Wound Healing

Moraes¹,

et al. 2016

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This study compares a wound dressing based on bacterial cellulose/collagen (BC/COL) hydrogel in rat dorsum with commercial collagenase ointment and untreated wound. The hydrogel was characterized by Scanning Electron Microscopy (SEM), Thermogravimetric Analysis (TGA), Fourier transformed -Infrared spectroscopy (FT-IR) and X-ray diffraction (XRD). According to the In vivo test and macroscopic evaluation, BC/COL hydrogel showed a better repair of wounds and promoted statistically significant differences of tissue repair between treatments on the 7th day after surgery. Better quality, quantity and orientation evaluation of collagen fibers (p=0.0001) were observed in the BC/COL hydrogel and collagenase ointment groups in relation to the control group. The BC/COL hydrogel promoted better wound healing than collagenase and the control group, therefore, it can be considered a potential wound dressing for skin regeneration.

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Section: In Vivo Experimentsmentioning

confidence: 99%

Bacterial Cellulose/Collagen Hydrogel for Wound Healing

Moraes¹,

et al. 2016

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“…The studies examining the effect of a hyper-hydrated environment were carried out using synthetic tissue culture medias and are very different in composition from chronic wound exudates. [50][51][52][53] Studies have shown that ulcer-derived exudate is fundamentally different from acute wound fluids. 71,72 The underlying pathological processes involved in chronic wound recalcitrance means that chronic exudate is highly damaging to tissues with its high content of protein-degrading enzymes.…”

Section: Exudate-dependent Tissue Damagementioning

confidence: 99%

The importance of hydration in wound healing: reinvigorating the clinical perspective

Ousey

Cutting

Rogers³

et al. 2016

J Wound Care

144

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Balancing skin hydration levels is important as any disruption in skin integrity will result in disturbance of the dermal water balance. The discovery that a moist environment actively supports the healing response when compared with a dry environment highlights the importance of water and good hydration levels for optimal healing. The benefits of ‘wet’ or ‘hyper-hydrated’ wound healing appear similar to those offered by moist over a dry environment. This suggests that the presence of free water may not be detrimental to healing, but any adverse effects of wound fluid on tissues is more likely related to the biological components contained within chronic wound exudate, for example elevated protease levels. Appropriate dressings applied to wounds must not only be able to absorb the exudate, but also retain this excess fluid together with its protease solutes, while concurrently preventing desiccation. This is particularly important in the case of chronic wounds where peri-wound skin barrier properties are compromised and there is increased permeation across the injured skin. This review discusses the importance of appropriate levels of hydration in skin, with a particular focus on the need for optimal hydration levels for effective healing. Declaration of interest: This paper was supported by Paul Hartmann Ltd. The authors have provided consultative services to Paul Hartmann Ltd.

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“…As it originates from ectoderm, its features are similar to human skin and hence could prevent dehydration, trauma, and associated infection commonly observed in disrupted skin wounds [9,10].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Amniotic Membrane Effectiveness in Skin Graft Donor Site Dressing in Burn Patients

et al. 2013

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Although the recipient site in burn wounds is dressed with universally accepted materials, the ideal management of split-thickness skin donor sites remains controversial. The aim of our study is to compare two methods of wound dressing in donor sites of split-thickness skin graft in patients undergoing burn wound reconstructive surgery. Forty-two consecutive patients with second-and thirddegree burns with a total body surface area between 20 and 40 % were enrolled in this randomized clinical trial conducted in Motahari Burn Hospital in Tehran, Iran. In each patient, two anatomic areas with similar features were randomly selected as intervention and control donor sites. The intervention site was dressed with amniotic membrane, whereas the control site was treated with Vaselineimpregnated gauze. Wounds were examined daily by expert surgeons to measure the clinical outcomes including duration of healing, severity of pain, and infection rate. The

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Dry, Moist, and Wet Skin Wound Repair

Cited by 158 publications

References 0 publications

Bacterial Cellulose/Collagen Hydrogel for Wound Healing

Bacterial Cellulose/Collagen Hydrogel for Wound Healing

The importance of hydration in wound healing: reinvigorating the clinical perspective

Evaluation of Amniotic Membrane Effectiveness in Skin Graft Donor Site Dressing in Burn Patients

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