Dry syrup: An overview

Ola, Monika; Bhaskar, Rajveer; Patil, Priya D.

doi:10.30750/ijpbr.6.3.5

Cited by 3 publications

(4 citation statements)

References 2 publications

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“…The dissolution of paracetamol instant jelly was carried out in 900 mL of a buffer solution with pH 5.8 at a paddle speed of 50 rpm. At scheduled intervals (15,20,30,45,60, and 120 min), 3 mL samples were taken, and an equivalent volume of the fresh dissolution medium was added. The aliquots, following suitable dilution, were analysed for drug content at 243 nm using a spectrophotometer Hitachi spectrophotometer model U-1900.…”

Section: In Vitro Drug Releasementioning

confidence: 99%

“…The paracetamol instant jelly in this study was prepared in dry form for reconstitution (single dose). The main reasons for this type of dosage form are to avoid chemical and physical stability problems, as well as to decrease the final product weight, because the aqueous vehicle is absent and, accordingly, transportation expenditures may be lessened [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

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Stability of Paracetamol Instant Jelly for Reconstitution: Impact of Packaging, Temperature and Humidity

Almurisi

AL-Japairai

Alshammari

et al. 2022

Gels

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The stability of the medicinal product is a major concern in the pharmaceutical industry and health authorities, whose goal is to guarantee that drugs are delivered to patients without loss of therapeutic properties. This study aims to evaluate the effect of environmental conditions and packaging on the stability of paracetamol instant jelly sachets based on both chemical and physical stability. The paracetamol instant jelly was packaged in plastic sachets (packaging 1) and sealed aluminium bags in screw-capped amber glass bottles (packaging 2), which were stored in real-time and accelerated stability chambers for 3 months. Samples were taken out from the chambers and were characterised for appearance, moisture content, texture, viscosity, in vitro drug release, paracetamol content, and 4-aminophenol level at different time points. The real-time storage condition at a lower temperature maintained the stability of the paracetamol instant jelly, while the accelerated condition led to a significant change in the formulation properties. In addition, the proper packaging of paracetamol instant jelly maintained the paracetamol’s stability, regardless of environmental conditions, for three months. The results show that the environmental conditions and packaging play a significant role in maintaining paracetamol instant jelly stability.

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Section: In Vitro Drug Releasementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Stability of Paracetamol Instant Jelly for Reconstitution: Impact of Packaging, Temperature and Humidity

Almurisi

AL-Japairai

Alshammari

et al. 2022

Gels

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“…Additionally, various drug delivery methods such as nasal, sublingual, buccal, rectal, vaginal, and ocular routes have been reported to pose some administration challenges and may be unsuitable for children, especially neonates and those under 2 years old [ 17 , 18 ]. Oral drug delivery systems (ODDSs), on the other hand, are considered more effective treatment strategies because they are easy to administer, simple, flexible, patient-friendly, painless, non-invasive, and stable [ 13 , 14 , 19 , 20 ]. Thus, the oral route remains the most suitable and popular channel of drug delivery for both infectious and non-infectious diseases in children, and it is the focus of the review.…”

Section: Introductionmentioning

confidence: 99%

Leading Paediatric Infectious Diseases—Current Trends, Gaps, and Future Prospects in Oral Pharmacotherapeutic Interventions

Rampedi,

Ogunrombi,

Adeleke

2024

Pharmaceutics

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Paediatric infectious diseases contribute significantly to global health challenges. Conventional therapeutic interventions are not always suitable for children, as they are regularly accompanied with long-standing disadvantages that negatively impact efficacy, thus necessitating the need for effective and child-friendly pharmacotherapeutic interventions. Recent advancements in drug delivery technologies, particularly oral formulations, have shown tremendous progress in enhancing the effectiveness of paediatric medicines. Generally, these delivery methods target, and address challenges associated with palatability, dosing accuracy, stability, bioavailability, patient compliance, and caregiver convenience, which are important factors that can influence successful treatment outcomes in children. Some of the emerging trends include moving away from creating liquid delivery systems to developing oral solid formulations, with the most explored being orodispersible tablets, multiparticulate dosage forms using film-coating technologies, and chewable drug products. Other ongoing innovations include gastro-retentive, 3D-printed, nipple-shield, milk-based, and nanoparticulate (e.g., lipid-, polymeric-based templates) drug delivery systems, possessing the potential to improve therapeutic effectiveness, age appropriateness, pharmacokinetics, and safety profiles as they relate to the paediatric population. This manuscript therefore highlights the evolving landscape of oral pharmacotherapeutic interventions for leading paediatric infectious diseases, crediting the role of innovative drug delivery technologies. By focusing on the current trends, pointing out gaps, and identifying future possibilities, this review aims to contribute towards ongoing efforts directed at improving paediatric health outcomes associated with the management of these infectious ailments through accessible and efficacious drug treatments.

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“…нул для оральної суспензії необхідні підтверджені точність дозування та швидкість вивільнення діючої речовини [16].…”

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Influence of pharmaceutical factors on the dissolution profile of granules for oral suspension with nimesulide

Tarapon

Тригубчак

2022

Farm Zh

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In vitro dissolution profiles are investigated to predict the behavior of the drug in the body and to establish its effectiveness. The choice of medium and dissolution conditions depends on the class of BSC of the active substance or substances that are part of the drug. In this work, nimesulide was chosen as a model substance, which is a sparingly soluble substance of class II BSC, when bioavailability is limited only by dissolution. The aim of the work was to establish optimal conditions for determining the dissolution profiles of Nimesulide, granules for oral solution, 100 mg/2 g and to study the effect of compositional variables on the release of API. The subject of the study was granules for oral suspension, made on the basis of nimesulide. In the experiment used the substance nimesulide 3 manufacturers, corn starch and macrogol 20 (polyethylene glycol) cetostearyl ether. The particle size of the substances was investigated by laser diffraction. Determination of nimesulide release was performed by HPLC. The results of the study of the dissolution profiles of the drug Aulin, granules for oral suspension in pH 6.8, 7.5 and 7.8, where the active substance is not completely released. The addition of surfactants was used to increase the solubility of the drug. It has been experimentally confirmed that when using API nimesulide with a particle size D (90) = 64 μm, the release profiles are below the comparison drug. The similarity of the dissolution profiles of the test agent and the comparison drug provide API with a particle size D (90) < 30 μm. The dependence of the dissolution profile on the amounts of corn starch and macrogol 20 (polyethylene glycol) of cetostearyl ether is given, their optimal content in the composition of the drug is established. In the result of the work, the influence of research conditions on the dissolution profile of Aulin, granules for oral suspension, 100 mg/2 g was studied. pH 6.8 + 1% tween 80 and pH 7.4 + 0.5% tween 80 were chosen as optimal media. Experiments showed that the particle size of API nimesulide D (90) < 30 μm ensures compliance with the drug Nimesulide, granules for oral suspension, 100 mg/2 g by dissolution profiles. Increasing the amount of corn starch in the composition of the drug accelerates the dissolution of the granules and, as a consequence, raises the first points of the release profile of API. The use of 0.5% corn starch provides the dissolution profile closest to the comparison drug. To completely release API as a solubilizer, it is advisable to add 1% macrogol 20 (polyethylene glycol) cetostearyl ether.

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Dry syrup: An overview

Cited by 3 publications

References 2 publications

Stability of Paracetamol Instant Jelly for Reconstitution: Impact of Packaging, Temperature and Humidity

Stability of Paracetamol Instant Jelly for Reconstitution: Impact of Packaging, Temperature and Humidity

Leading Paediatric Infectious Diseases—Current Trends, Gaps, and Future Prospects in Oral Pharmacotherapeutic Interventions

Influence of pharmaceutical factors on the dissolution profile of granules for oral suspension with nimesulide

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