DSA-Based Quantitative Assessment of Cerebral Hypoperfusion in Patients with Asymmetric Carotid Stenosis

Zhang, Xu; Gao, Jie; Yao, Xinke; Dai, Zhengze; Xu, Gelin; Cai, Ying; Li, Zhiyong

doi:10.32604/mcb.2019.06140

Cited by 6 publications

(3 citation statements)

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“…DSA is also useful in predicting the cerebral hyperperfusion phenomenon (HPP) developed upon carotid interventions. HPP is of low incidence but it can lead to morbidity and mortality, and may cause watershed cerebral infarction [16]. Indirectly measuring the cerebral circulation time (CCT), using the time to reach maximum contrast intensity, DSA can predict HPP (prolonged CCT) with a sensitivity and specificity of 75% and 100%, respectively [17].…”

Section: Introductionmentioning

confidence: 99%

Imaging modalities to diagnose carotid artery stenosis: progress and prospect

2019

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In the past few decades, imaging has been developed to a high level of sophistication. Improvements from one-dimension (1D) to 2D images, and from 2D images to 3D models, have revolutionized the field of imaging. This not only helps in diagnosing various critical and fatal diseases in the early stages but also contributes to making informed clinical decisions on the follow-up treatment profile. Carotid artery stenosis (CAS) may potentially cause debilitating stroke, and its accurate early detection is therefore important. In this paper, the technical development of various CAS diagnosis imaging modalities and its impact on the clinical efficacy is thoroughly reviewed. These imaging modalities include duplex ultrasound (DUS), computed tomography angiography (CTA) and magnetic resonance angiography (MRA). For each of the imaging modalities considered, imaging methodology (principle), critical imaging parameters, and the extent of imaging the vulnerable plaque are discussed. DUS is usually the initial recommended CAS diagnostic examination. However, for the therapeutic intervention, either MRA or CTA is recommended for confirmation, and for added information on intracranial cerebral circulation and aortic arch condition for procedural planning. Over the past few decades, the focus of CAS diagnosis has also shifted from pure stenosis quantification to plaque characterization. This has led to further advancement in the existing imaging tools and development of other potential imaging tools like Optical coherence tomography (OCT), photoacoustic tomography (PAT), and infrared (IR) thermography.

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Section: Introductionmentioning

confidence: 99%

Imaging modalities to diagnose carotid artery stenosis: progress and prospect

2019

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“…-вырабатывая различные биологически активные вещества, -принимает самое активное участие в поддержании сосудистого тонуса, атеромбогенности сосудистой стенки, регуляции адгезии и агрегации тромбоцитов, -проявляет про-и антикоагулянтную, фибринолитическую активность, -участвует в процессах воспаления [5][6][7]18]. Этапы эволюции атеросклеротической бляшки ассоциированы с эндотелиальной дисфункцией.…”

Section: вікові і статеві відмінності мозкового кровообігу у пацієнтіunclassified

Age and Sex Differences in Cerebral Circulation in Patients with Cerebral Atherosclerosis and Diabetes mellitus

Cherska

Гуріанов

Коміссарова

2020

FMEP

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Cerebrovascular pathology and metabolic disorders are problems of modern health care, which are of colossal medical and social significance. A high percentage of not only mortality, but also disability determines the extreme urgency of studying their various aspects, and the presence of combined pathology requires the development of a personalized approach to the tactics of managing such patients.The objective: was to determine sex and age differences in the structural and functional state of the vessels of the carotid and vertebro-basilar basins in patients with stage I–III cerebral atherosclerosis (CA) and type 2 diabetes mellitus.Materials and methods. A comprehensive clinical and instrumental study involved 229 patients with stageI–IIICA and type 2 diabetes mellitus. The patients were divided into 2 groups: I – the general group of patients who had an ischemic atherothrombotic stroke in the middle cerebral artery basin – CA III; II – with CA I–II stages. All patients underwent conventional clinical, laboratory and instrumental studies (Doppler ultrasound of the vessels of the head and neck – study of cerebral blood flow in the extra- and intracranial sections of the main arteries of the head and neck using the Aplio XG device (Toshiba).Results. In patients of group I, there were no age or sex differences in the linear systolic blood flow velocity (LSBFV) of the vessels of the carotid and vertebro-basilar basins. In group II patients over 60 years of age, the LSBFV in both internal carotid arteries was statistically significantly higher than in middle-aged patients, while the LSBFV in the left vertebral, posterior cerebral arteries and the basilar artery was statistically significantly higher in middle-aged patients than in the elderly. In our opinion, these differences can be explained by statistically significant differences in fasting blood glucose levels. It is important to note that statistically significant sex differences were found only for LSBFV in both common carotid arteries: in women with CA stages I-II, the rate of cerebral blood flow was higher than in men.Conclusions. For patients with stage III CA and T2DM, age and sex differences in the parameters of cerebral circulation both in the vessels of the carotid and in the vessels of the vertebro-basilar basins have not been established. Elderly patients with stage I–II CA and T2DM, in comparison with middle-aged patients, are characterized by a statistically significantly higher LSBFV in the vessels of the carotid basin and lower in the vessels of the vertebro-basilar basin. The rate of cerebral blood flow in female patients with stage I–II CA and diabetes mellitus is statistically significantly higher in both common carotid arteries, in contrast to the corresponding LSBFV indicators in male patients.

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“…DSA is also useful in predicting the cerebral hyperperfusion phenomenon (HPP) developed upon carotid interventions. HPP, of low incidence but it can lead to morbidity and mortality, may cause watershed cerebral infarction [51]. Indirectly measuring the cerebral circulation time (CCT), using the time to reach maximum contrast intensity, DSA can predict HPP (prolonged CCT) with a sensitivity and specificity of 75% and 100%, respectively [52].…”

Section: Digital Subtraction Angiography (Dsa)mentioning

confidence: 99%

Carotid artery stenosis (CAS) disease detection by passive and active medical infrared (IR) thermal imaging

Saxena¹

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DSA-Based Quantitative Assessment of Cerebral Hypoperfusion in Patients with Asymmetric Carotid Stenosis

Cited by 6 publications

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Imaging modalities to diagnose carotid artery stenosis: progress and prospect

Imaging modalities to diagnose carotid artery stenosis: progress and prospect

Age and Sex Differences in Cerebral Circulation in Patients with Cerebral Atherosclerosis and Diabetes mellitus

Carotid artery stenosis (CAS) disease detection by passive and active medical infrared (IR) thermal imaging

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