2008
DOI: 10.1016/j.conb.2008.05.005
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Dscam-mediated repulsion controls tiling and self-avoidance

Abstract: SummaryRecent studies have uncovered the molecular basis of self-avoidance and tiling, two fundamental principles required for the formation of neural circuits. Both of these wiring strategies are established through homophilic repulsion between Dscam proteins expressed on opposing cell surfaces. In Drosophila, Dscam1 mediates self-avoidance whereas Dscam2 mediates tiling. In contrast, phenotypes in the retina of the DSCAM mutant mouse indicate that DSCAM functions in both selfavoidance and tiling. These findi… Show more

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Cited by 57 publications
(56 citation statements)
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“…Most are thought to be inhibitory, and therefore self-limiting, maintaining the precision with which a neuron fires action potentials (46). Normally, neurites are rigorously excluded from contacting their own neuron; in Drosophila, the cell adhesion molecule Dscam1 promotes the repulsion of processes of the same neuron among axons (43) and synapses (25). We tentatively interpret autapses on cell types Mi1 and Dm9 to reflect the reduced effectiveness at these two specific neurons of DScam1-mediated self-exclusion, which normally prevents the self-contact that occurs at autapses.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Most are thought to be inhibitory, and therefore self-limiting, maintaining the precision with which a neuron fires action potentials (46). Normally, neurites are rigorously excluded from contacting their own neuron; in Drosophila, the cell adhesion molecule Dscam1 promotes the repulsion of processes of the same neuron among axons (43) and synapses (25). We tentatively interpret autapses on cell types Mi1 and Dm9 to reflect the reduced effectiveness at these two specific neurons of DScam1-mediated self-exclusion, which normally prevents the self-contact that occurs at autapses.…”
Section: Discussionmentioning
confidence: 99%
“…Combining these lines of evidence (the presence of errors on every cell type, their lack of obvious function, comparability with other error sources, and fewer errors on cells with more synapses) leads us to conclude that ICs simply indicate the accuracy attained by the mechanisms of neuronal synaptogenesis when wiring the medulla. These mechanisms may include the mechanisms of chemoaffinity (42) or those mechanisms involved in exclusion of incorrect connections through selfavoidance (43,44). These mechanisms, along with other cell surface and secreted molecules, are thought to regulate synaptogenesis between synaptic partners, forming the basis for the accuracy of synaptic connections we report.…”
Section: Discussionmentioning
confidence: 99%
“…Drosophila DSCAM1, a gene alternatively spliced to produce Ͼ38,000 possible protein isoforms (Schmucker et al, 2000), providing the basis for self-avoidance and tiling (Millard and Zipursky, 2008). Although the mammalian DSCAM gene is unable to generate such wide molecular diversity, it has been demonstrated to mediate homophilic repulsion, promoting dendrite self-avoidance in the developing mouse retina (Fuerst et al, 2008(Fuerst et al, , 2009.…”
Section: Discussionmentioning
confidence: 99%
“…In numerous cell types, dendritic branches that originate from the same neuron (sister branches) will not cross or fasciculate, and this self-avoidance (see Glossary, Box 2) ensures that dendritic arbors spread evenly across their territory (Grueber et al, 2002; Kramer and Kuwada, 1983;Millard and Zipursky, 2008;Sugimura et al, 2003). By contrast, branches from different neurons can co-exist.…”
Section: Dscam Control Of Dendritic Self-avoidance In Drosophilamentioning
confidence: 99%