DSM-5 en pacientes que solicitan el primer tratamiento del trastorno por uso de alcohol. Diferencias de sexo en el estudio multicéntrico CohRTA

Sanvisens, Arantza; Rubio, Gabriel; Short, Antoni; Gual, Antoni; Álvarez, Francisco; Torrens, Marta; Fonseca, Fernando Rodrı́guez de; Muga, Roberto; CohRTA, Estudio CohRTA Estudio

doi:10.20882/adicciones.1177

Cited by 6 publications

(1 citation statement)

References 32 publications

(40 reference statements)

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“…The DSM-5 defines AUD as a problematic pattern of alcohol use leading to clinically significant impairment or distress, as manifested by at least 2 of the following 11 symptoms occurring within 12-months [38][39][40].…”

Section: Item Diagnostic Criteria or Characteristicsmentioning

confidence: 99%

Molecular Toxicology and Pathophysiology of Comorbid Alcohol Use Disorder and Post-Traumatic Stress Disorder Associated with Traumatic Brain Injury

Wang

Luo

Zhou

et al. 2023

IJMS

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The increasing comorbidity of alcohol use disorder (AUD) and post-traumatic stress disorder (PTSD) associated with traumatic brain injury (TBI) is a serious medical, economic, and social issue. However, the molecular toxicology and pathophysiological mechanisms of comorbid AUD and PTSD are not well understood and the identification of the comorbidity state markers is significantly challenging. This review summarizes the main characteristics of comorbidity between AUD and PTSD (AUD/PTSD) and highlights the significance of a comprehensive understanding of the molecular toxicology and pathophysiological mechanisms of AUD/PTSD, particularly following TBI, with a focus on the role of metabolomics, inflammation, neuroendocrine, signal transduction pathways, and genetic regulation. Instead of a separate disease state, a comprehensive examination of comorbid AUD and PTSD is emphasized by considering additive and synergistic interactions between the two diseases. Finally, we propose several hypotheses of molecular mechanisms for AUD/PTSD and discuss potential future research directions that may provide new insights and translational application opportunities.

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Section: Item Diagnostic Criteria or Characteristicsmentioning

confidence: 99%

Molecular Toxicology and Pathophysiology of Comorbid Alcohol Use Disorder and Post-Traumatic Stress Disorder Associated with Traumatic Brain Injury

Wang

Luo

Zhou

et al. 2023

IJMS

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Gender Differences in Alcohol Use: a Nationwide Study in a Multiethnic Population

Goh

Asharani

Abdin

et al. 2022

Int J Ment Health Addiction

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The increase in alcohol consumption, and the greater consequences of chronic alcohol use among females, as well as the convergence of the gender gap warrants investigation. This paper aims to uncover gender differences in individuals with alcohol use disorder (AUD) in Singapore. The SMHS 2016 was a population-based, cross-sectional, epidemiological study. Recruitment spanned from August 2016 to March 2018, where 6126 respondents were recruited. Similarly to global estimates, lifetime prevalence and 12-month prevalence for AUD were higher in males than females. However, females had a higher prevalence of obsessive–compulsive disorder (OCD) co-morbidity than males. Women also had an earlier onset and age of recovery of AUD than men. Alarmingly, male (94.14%) and female (100%) respondents reported low help-seeking for their AUD. Gender differences in individuals with AUD were identified in Singapore population. Future research should direct its effort to identify barriers to help-seeking for individuals with alcohol use disorder.

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Hormonal Differences Between Women and Men, Their Consequences on Addiction to Substances and Considerations on the Therapeutic Approach

Balmorí¹,

Macías²,

Puente³

2022

Curr Addict Rep

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DSM-5 en pacientes que solicitan el primer tratamiento del trastorno por uso de alcohol. Diferencias de sexo en el estudio multicéntrico CohRTA

Abstract: DSM-5 en pacientes que solicitan el primer tratamiento del trastorno por uso de alcohol. Diferencias de sexo en el estudio multicéntrico CohRTA DSM-5 in patients seeking their first treatment for alcohol use disorder. Sex differences in the multicenter CohRTA study

Cited by 6 publications

References 32 publications

Molecular Toxicology and Pathophysiology of Comorbid Alcohol Use Disorder and Post-Traumatic Stress Disorder Associated with Traumatic Brain Injury

Molecular Toxicology and Pathophysiology of Comorbid Alcohol Use Disorder and Post-Traumatic Stress Disorder Associated with Traumatic Brain Injury

Gender Differences in Alcohol Use: a Nationwide Study in a Multiethnic Population

Hormonal Differences Between Women and Men, Their Consequences on Addiction to Substances and Considerations on the Therapeutic Approach

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