Dual Anticancer and Antibacterial Properties of Silica-Based Theranostic Nanomaterials Functionalized with Coumarin343, Folic Acid and a Cytotoxic Organotin(IV) Metallodrug

Abstract

Five different silica nanoparticles functionalized with vitamin B12, a derivative of coumarin found in green plants and a minimum content of an organotin(IV) fragment (1-MSN-Sn, 2-MSN-Sn, 2-SBA-Sn, 2-FSPm-Sn and 2-FSPs-Sn), were identified as excellent anticancer agents against triple negative breast cancer, one of the most diagnosed and aggressive cancerous tumors, with very poor prognosis. Notably, compound 2-MSN-Sn shows selectivity for cancer cells and excellent luminescent properties detectable by imaging techniques once internalized. The same compound is also able to interact with and nearly eradicate biofilms of Staphylococcus aureus, the most common bacteria isolated from chronic wounds and burns, whose treatment is a clinical challenge. 2-MSN-Sn is efficiently internalized by bacteria in a biofilm state and destroys the latter through reactive oxygen species (ROS) generation. Its internalization by bacteria was also efficiently monitored by fluorescence imaging. Since silica nanoparticles are particularly suitable for oral or topical administration, and considering both its anticancer and antibacterial activity, 2-MSN-Sn represents a new dual-condition theranostic agent, based primarily on natural products or their derivatives and with only a minimum amount of a novel metallodrug.

Biomineral-Based Composite Materials in Regenerative Medicine

“…These Silica/Fn-SFP nanoparticles exhibited high drug-loading capacities along with pH-responsive drug release patterns and a dual DDS [ 232 ]. Leveraging this biocompatible framework, a dual DDS was developed, capable of concurrently administering anticancer drugs and any other type of drug, such as antibiotics, thus effectively combating cancer and microbial infections [ 35 , 233 , 234 ].…”

Critical view on antimicrobial, antibiofilm and cytotoxic activities of quinazolin-4(3H)-one derived schiff bases and their Cu(II) complexes

“…The authors have long been engaged in the study of various types of heterocycles [ 3 , [15] , [16] , [17] , [18] , [19] ], primarily as anti-infective and anti-cancer agents with the aim of obtaining substances with dual (anti-cancer + antibacterial) activity [ [20] , [21] , [22] , [23] , [24] , [25] , [26] ], because such therapeutics are particularly advantageous in the treatment of oncological patients who have drug-suppressed immunity and for whom even banal infections and opportunistic pathogens are a threat. So impressed with the global interest in quinazolin-4(3 H )-ones as antibacterial compounds [ 4 , [27] , [28] , [29] , [30] , [31] ], the previously described anticancer 2,3-disubstituted-quinazolin-4(3 H )-one derived Schiff bases [ 32 , 33 ] were screened for their antimicrobial activity, and their cytotoxic potential was tested against the human monocytic leukemia cell line THP-1 and thus the spectrum of cytotoxic activities published earlier [ 32 , 33 ] was extended to another line.…”

Melatonin Derivative-Conjugated Formulations of Pd(II) and Pt(II) Thiazoline Complexes on Mesoporous Silica to Enhance Cytotoxicity and Apoptosis against HeLa Cells

“…Using this covalent functionalization procedure, the incorporation of other molecules of interest, e.g., a targeting molecule, to increase the selectivity of the designed systems is possible [ 12 , 13 , 14 ]. For example, systems based on silica functionalized with proteins [ 15 , 16 ], vitamins [ 17 , 18 , 19 ] or sugars [ 20 , 21 ] have been prepared and have been shown to increase their biological activity mainly due to greater accumulation in the target area compared with that in those systems not having the targeting molecule.…”