Dual antioxidant activity and the related mechanisms of a novel pentapeptide GLP4 from the fermented mycelia of<i>Ganoderma lingzhi</i>

Huang, Ping; Luo, Feijun; Ma, You-Chu; Wang, Si-Xian; Huang, Jian; Qin, Dandan; Xue, Fei-Fei; Liu, Bi-Yang; Wu, Qiang; Wang, Xiaoling; Liu, Gao-Qiang

doi:10.1039/d2fo01572b

Cited by 9 publications

(5 citation statements)

References 57 publications

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“…(Li et al, 2018;Mishra et al, 2021). Estudos indicam que diferentes espécies de Ganoderma podem ser cultivadas in vitro, resultando em uma ampla gama de metabólitos secundários com diversas atividades biológicas, como efeitos hipotensores, citotóxicos, antioxidantes, imunomoduladores, entre outros (Cilerdzic et al, 2016;Huang et al, 2022;Liu et al, 2016;Xiao et al, 2020).…”

Section: Moléculas Bioativas De Ganoderma Sppunclassified

Perspectivas do potencial imunomodulador e antineoplásico de polissacarídeos e outras biomoléculas de Ganoderma spp.

Silva,

Chevreuil,

Silva

et al. 2024

OLEL

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Os polissacarídeos derivados de espécies fúngicas pertencentes ao gênero Ganoderma têm sido reconhecidos como agentes importantes tanto na modulação do sistema imunológico quanto na inibição do crescimento tumoral. Este estudo objetivou destacar a capacidade antineoplásica e imunomoduladora in vitro dos polissacarídeos de Ganoderma. Foi demonstrado que esses polissacarídeos são capazes de estimular a atividade de células imunes, fortalecendo assim resposta imunológica contra células tumorais. Adicionalmente, esses compostos naturais mostram-se capazes de prevenir, bloquear ou mesmo reverter o desenvolvimento do câncer, com potencial para mitigar os efeitos colaterais associados aos tratamentos convencionais. É importante ressaltar que esses compostos também exibem atividades antineoplásicas, retardando o crescimento e a disseminação de tumores. O potencial imunomodulador e antineoplásico dos polissacarídeos de Ganoderma pode representar uma fonte promissora de tratamentos adjuvantes e alternativos para o câncer e outras doenças relacionadas ao sistema imunológico. Diante dos desafios e limitações da quimioterapia, os medicamentos fitoterápicos emergem como alternativas promissoras no tratamento do câncer. Nesse contexto, os polissacarídeos extraídos de Ganoderma, um cogumelo medicinal, despertam crescente interesse devido às suas propriedades comprovadas de quimioprevenção e antineoplásicas.

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Section: Moléculas Bioativas De Ganoderma Sppunclassified

Perspectivas do potencial imunomodulador e antineoplásico de polissacarídeos e outras biomoléculas de Ganoderma spp.

Silva,

Chevreuil,

Silva

et al. 2024

OLEL

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“…MBPs may regulate the expression of related antioxidant proteins by down-regulating the Keapl gene and up-regulating Nrf2 gene expression (Figure 2) [31]. The GLP [39] promoted Nrf2 and activated the Nrf2-ARE signalling pathway, exhibiting antioxidant effects on cells induced by hydrogen peroxide (H 2 O 2 ). Nrf2 dissociated from Keap1 upon stimulation of the PI3K/AKT and MAPK pathways, moving to the nucleus, and associated with the antioxidant component ARE, which regulated the expression of antioxidant enzymes such as HO-1, catalase (CAT), etc.…”

Section: Antioxidant Activitymentioning

confidence: 99%

Bioactive Peptides from Edible Mushrooms—The Preparation, Mechanisms, Structure—Activity Relationships and Prospects

Gao

Zhao

et al. 2023

Foods

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Mushroom bioactive peptides (MBPs) are bioactive peptides extracted directly or indirectly from edible mushrooms. MBPs are known to have antioxidant, anti-aging, antibacterial, anti-inflammatory and anti-hypertensive properties, and facilitate memory and cognitive improvement, antitumour and anti-diabetes activities, and cholesterol reduction. MBPs exert antioxidant and anti-inflammatory effects by regulating the MAPK, Keap1-Nrf2-ARE, NF-κB and TNF pathways. In addition, MBPs exert antibacterial, anti-tumour and anti-inflammatory effects by stimulating the proliferation of macrophages. The bioactivities of MBPs are closely related to their molecular weights, charge, amino acid compositions and amino acid sequences. Compared with animal-derived peptides, MBPs are ideal raw materials for healthy and functional products with the advantages of their abundance of resources, safety, low price, and easy-to-achieve large-scale production of valuable nutrients for health maintenance and disease prevention. In this review, the preparation, bioactivities, mechanisms and structure–activity relationships of MBPs were described. The main challenges and prospects of their application in functional products were also discussed. This review aimed to provide a comprehensive perspective of MBPs.

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“…Additionally, Ganoderma lucidum polysaccharides exhibit a beneficial effect in mitigating lipopolysaccharide-induced acute pneumonia by inhibiting inflammation mediated by NRP1 [ 38 ]. Our team has previously characterized the amino acid sequence of GLP4, Gln–Arg–Val–Cys–Glu, noting its potent dual antioxidant activities [ 39 ]. Building on this foundation, the present study explores the protective capabilities of GLP4 against lung injury induced by cadmium poisoning in mice.…”

Section: Introductionmentioning

confidence: 99%

The Protective Effects of Ganoderma lucidum Active Peptide GLP4 on Lung Injury Induced by Cadmium Poisoning in Mice

Zhu,

Wang,

Liu

2024

Toxics

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Ganoderma triterpenes and spore powder have shown promising results in mitigating cadmium-induced renal and hepatic injuries. Ganoderma lucidum active peptide GLP4 is a natural protein with dual antioxidant activities derived from the mycelium of Ganoderma lucidum. However, its efficacy in alleviating cadmium-induced lung injury remains unexplored. This study aims to investigate the protective effects of GLP4 against cadmium-induced lung injury in mice. Mice were exposed to cadmium chloride via nebulization to induce lung injury. The protective effect of GLP4 was assessed by measuring the total cell count in BALF, levels of inflammatory cytokines, and the expression of NLRP3 in lung tissues a through histopathological examination of lung tissue changes. The results showed that GLP4 significantly mitigated histopathological damage in lung tissues, decreased the secretion of inflammatory cytokines, and reduced the expression of NLRP3, which was elevated in cadmium-exposed mice. In vitro studies further revealed that GLP4 inhibited the cadmium-induced activation of the NLRP3 inflammasome. Notably, acute cadmium exposure by the respiratory tract did not affect the liver and kidneys of the mice. The findings suggest that GLP4 reduces cadmium-induced lung injury in mice by inhibiting the activation of the NLRP3 inflammasome, which provides a theoretical foundation for using Ganoderma lucidum as a preventive and therapeutic agent against cadmium poisoning.

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Dual antioxidant activity and the related mechanisms of a novel pentapeptide GLP4 from the fermented mycelia ofGanoderma lingzhi

Abstract: Oxidative stress causes chronic inflammation, and mediates various diseases. The discovery of antioxidants from natural sources is important to research. Here we identified a novel antioxidant peptide (GLP4) from Ganoderma...

Cited by 9 publications

References 57 publications

Perspectivas do potencial imunomodulador e antineoplásico de polissacarídeos e outras biomoléculas de Ganoderma spp.

Perspectivas do potencial imunomodulador e antineoplásico de polissacarídeos e outras biomoléculas de Ganoderma spp.

Bioactive Peptides from Edible Mushrooms—The Preparation, Mechanisms, Structure—Activity Relationships and Prospects

The Protective Effects of Ganoderma lucidum Active Peptide GLP4 on Lung Injury Induced by Cadmium Poisoning in Mice

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