Dual-channel differential surface plasmon ellipsometry for bio-chemical sensing

Hooper, Ian R.; Rooth, Maxim; Sambles, J. R.

doi:10.1016/j.bios.2009.07.023

Cited by 23 publications

(9 citation statements)

References 43 publications

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“…Later they reported the multiplexing capability of their SPR polarimetry system and compared its performance with the commercially available Nomadics SensiQ discovery system. Here, a higher signal to noise ratio as well as lower detection limit were obtained [80].…”

Section: Polarimetrymentioning

confidence: 70%

“…This immobilization process has made label-free characterization of bio-interactions possible. In 2009, Hooper et al [80] built a highly sensitive dualchannel differential phase sensitive SPR sensor and applied it for characterization of interaction between BSA, transferrin and their specific antibodies. A self assembled monolayer was first formed by injecting 1 mM solution of 16-mercaptohexadecanoic acid across the gold coated SF2 slide.…”

Section: Monitoring and Characterization Of Interactionsmentioning

confidence: 99%

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Phase‐sensitive surface plasmon resonance biosensors: methodology, instrumentation and applications

et al. 2012

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International audienceSurface Plasmon Resonance (SPR) has become a central tool for label-free characterization of biomolecular interactions. Based on monitoring of amplitude characteristics, conventional SPR sensors have been extensively explored, commercialized and applied for studies of many important interactions (antigen-antibody, protein-ligand etc), but this technology still lacks of sensitivity for the detection of relatively small and low copy number compounds. Phase-sensitive SPR has recently emerged as an upgrade of this technology to resolve the sensitivity issue. Profiting from a sharp phase jump under SPR and ultra-sensitive tools of its control, this technology offers up to 100-time improvement of the detection limit, giving access to the detection of trace amounts of small molecular weight analytes (drugs etc). This paper intends to provide a tutorial on basic concepts of phase detection in SPR sensing, compare the performance of phase- and amplitude-sensitive sensors, review recent progress in the development and applications of phase-sensitive SPR sensors, and outline future prospects and trends of this technology

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Section: Polarimetrymentioning

confidence: 70%

Section: Monitoring and Characterization Of Interactionsmentioning

confidence: 99%

Phase‐sensitive surface plasmon resonance biosensors: methodology, instrumentation and applications

et al. 2012

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“…There have been reported two types of optical systems based on the Kretschmann configuration for multi-analyte SPR sensors. [11][12][13][14][15][16][17][18][19][20][21] The first type of SPR sensor is a so-called SPR imaging sensor, where a 2-dimension CCD sensor is used for measuring reflected light from the sensor chip, on which a multi-channel or micro array was fabricated. [11][12][13][14] For example, Piliarik et al 11 reported a high-throughput SPR imaging sensor for nucleic acids, while identifying a specific bacteria pathogenous.…”

Section: Introductionmentioning

confidence: 99%

“…The second type of SPR sensor, based on the Kretschmann configuration, is that beam splitters [15][16][17] or a cylindrical lens array 18 can be used to divide a single mono-chromatic incident light beam into multi-beams. For example, Hemmi et al 15 developed this type SPR sensor by utilizing several cubic beam splitters to generate 9 beams for 9 sensing points.…”

Section: Introductionmentioning

confidence: 99%

“…However, the incident light intensities of the beams were different due to the fact that beams passed through several beam splitters for the generation of the multi-beams. In addition, Mauriz et al 16 and Hooper et al 17 also developed similar multi-channel SPR sensors by using a single beam splitter and a cylindrical lens array for generating incident light beams. 18 The intensities of the reflected light for the multi-beams were detected by a two-dimensional CCD sensor in both cases.…”

Section: Introductionmentioning

confidence: 99%

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Development of a Portable Surface Plasmon Resonance Sensor with Multi-Sensing Points Based on the Linear CCD Sensor

et al. 2016

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A portable-type surface plasmon resonance (SPR) sensor, composed from a new optical system for multi-sensing, has been developed to apply to environment analysis, clinical diagnosis etc., where many samples are desired to be analyzed at high throughput. The optical system of the sensor consists of a light-emitting diode, a pair of cylindrical lenses, a pair of collimator lenses, a correction lens, a prism, a polarizer and a linear CCD sensor with 2048 pixels. Reflected light from a sensor chip of the width of 6 mm at a certain incident angle was detected by ca. 618 pixels of the linear CCD sensor as an SPR sensor signal. An SPR sensor signal at a specified incident angle is controllable for optimization by adjusting the position of the CCD sensor. A sensor chip having a 30-stripe linear pattern (100 μm width/stripe) was prepared. The spatial resolution as well as the performance of the sensor were evaluated by using sucrose solutions. As a result, the acquisition of SPR sensor signals from 30 sensing points was successfully achieved with a spatial resolution of 100 μm (distance between 2 sensing points). A lower detection limit of ca. 3.2 -5.5 × 10 -5 RIU with a standard deviation of ±4.5% was obtained by averaging the signals from 6 -7 pixels of the CCD sensor per one sensing stripe.

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SPR Biosensors

Kong

et al. 2017

Handbook of Photonics for Biomedical Engineering

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Dual-channel differential surface plasmon ellipsometry for bio-chemical sensing

Cited by 23 publications

References 43 publications

Phase‐sensitive surface plasmon resonance biosensors: methodology, instrumentation and applications

Phase‐sensitive surface plasmon resonance biosensors: methodology, instrumentation and applications

Development of a Portable Surface Plasmon Resonance Sensor with Multi-Sensing Points Based on the Linear CCD Sensor

SPR Biosensors

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