Dual dynamically crosslinked thermosensitive hydrogel with self-fixing as a postoperative anti-adhesion barrier

Li, Ziyi; Liu, Lixin; Chen, Yongming

doi:10.1016/j.actbio.2020.04.034

Cited by 80 publications

(43 citation statements)

References 51 publications

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“…Dynamic hydrogels are a new generation of hydrogels which are crosslinked by dynamic covalent bonding via S N 2-type nucleophilic substitution [8], imine chemistry [9], Diels-Alder reaction [10], etc. Generally, they are responsive to external stimuli, such as light, temperature, and pH [11][12][13]. A dynamic hydrogel was formed by specific benzoxaborole-carbohydrate interactions between benzoxaborolemodified hyaluronic acid and fructose-based glycopolymer.…”

Section: Introductionmentioning

confidence: 99%

“…A thermos-sensitive hydrogel was generated by dynamic chemical oxime bonding from alkoxyamineterminated Pluronic F127 and oxidized hyaluronic acid, as well as hydrophobic association. The hydrogel exhibits much higher modulus and higher stability than the Pluronic F127 hydrogel, and could be used as a promising postoperative anti-adhesion material in clinical practice [12]. On the other hand, soft hydrogels based on alginate-boronic acid were obtained from reversible inter-and intramolecular interactions by dynamic equilibrium of boronic acid-diol complexation and dissociation.…”

Section: Introductionmentioning

confidence: 99%

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Anti-bacterial dynamic hydrogels prepared from O-carboxymethyl chitosan by dual imine bond crosslinking for biomedical applications

Saint-Cyr

Soussan

et al. 2021

International Journal of Biological Macromolecules

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Imine dynamic hydrogels are synthesized via dual-imine bond crosslinking from O-carboxymethyl chitosan (CMCS) and a water soluble dynamer using a 'green' approach. Three dynamers are prepared through reaction of benzene-1,3,5-tricarbaldehyde and di-amino Jeffamine with molar mass of 500, 800 and 1900, respectively. Hydrogels, namely H500, H800 and H1900 are then obtained by mixing CMCS and dynamer aqueous solutions. FT-IR confirms the formation of hydrogels via imine bonding. H1900 presents larger pore size and higher storage modulus as compared to H500 and H800 due to the higher molar mass of Jeffamine linker. The hydrogels exhibit pH sensitive swelling behavior due to electrostatic attraction or repulsion in the pH range from 3 to 10. The highest swelling ratio is obtained at pH 8, reaching 7500% for H800. Self-healing of hydrogels is evidenced by rheological measurements with alternatively applied low and high strains, and by using a macroscopic approach with re-integration of injected filaments. Furthermore, the H1900 membrane exhibits outstanding antibacterial activity against an E. coli suspension at 10 8 CFU mL −1 . Therefore, dynamic hydrogels synthesized from CMCS and Jeffamine present outstanding rheological, swelling, self-healing and antibacterial properties, and are most promising as healthcare material in wound dressing, drug delivery and tissue engineering.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anti-bacterial dynamic hydrogels prepared from O-carboxymethyl chitosan by dual imine bond crosslinking for biomedical applications

Saint-Cyr

Soussan

et al. 2021

International Journal of Biological Macromolecules

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“…In order to clarify our upshot exactly, we first estimated mechanical properties of PCT hydrogels with different Ti 3 C 2 Tx composite contents at room temperature 46 . The resultant PCT hydrogels exhibited large deformability, including stretching, bending, and twisting.…”

Section: Resultsmentioning

confidence: 99%

Ti₃C₂Tx MXenes reinforced PAA/CS hydrogels with self‐healing function as flexible supercapacitor electrodes

Lei

Zhou

et al. 2021

Polymers for Advanced Techs

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Lightweight, thin, and stretchable flexible microelectronic devices have become a new challenge for researchers. To provide power for these conformable devices, it is necessary to design the energy storage device into a flexible and stretchable structure. In this paper, a two‐step method was used to prepare a dual‐physical cross‐linked polyacrylic acid/chitosan/Ti3C2Tx(PCT) conductive hydrogel flexible electrode. The three‐dimensional (3D) porous structure not only offers a good electrical connection, but also saves the use of binder and additional current collector, which helps to enhance the electrochemical properties of electrode. The unique two‐dimensional layered structure of Ti3C2Tx enables the hydrogel electrode to withstand considerable pressure deformation without breaking, and has excellent tensile properties. The flexible electrode exhibited an excellent tensile strength of 0.083 MPa if only introduced 0.31 wt% of Ti3C2Tx with the tensile strain of 158.63% and owned remarkable self‐healing properties after injury. Thereby, the hydrogel electrode renders a maximum capacitance of 291.8 mF g−1 at 0.5 mA/g and a good cycling stability with 64.24% capacitance retention after 2000 charge–discharge cycles. This provides a research and development strategy for binder‐free, non‐toxic, and mini‐size flexible energy storage devices.

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“…have developed dual dynamically crosslinked thermosensitive hydrogel by alkoxyamine‐terminated pluronic F127 (AOP127) and oxidized hyaluronic acid (OHA) for the prevention of postoperative adhesion barrier. [ 141 ] Li et al. 's animal experiment (rat model of side‐wall defect‐bowel abrasion model) outcomes demonstrated a significant decrease in PPA in the animal group that is treated with AOP127/OHA‐based hydrogel, while the animals treated with normal saline or pluronic F127 hydrogel did not show any antiadhesion prevention efficacy.…”

Section: Biomaterials To Fabricate Antiadhesion Barriersmentioning

confidence: 99%

Advancement of Biomaterial‐Based Postoperative Adhesion Barriers

Chandel

Shimizu

Hasegawa

et al. 2021

Macromolecular Bioscience

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Postoperative peritoneal adhesion (PPA) is a prevalent incidence that generally happens during the healing process of traumatized tissues. It causes multiple severe complications such as intestinal obstruction, chronic abdominal pain, and female infertility. To prevent PPA, several antiadhesion materials and drug delivery systems composed of biomaterials are used clinically, and clinical antiadhesive is one of the important applications nowadays. In addition to several commercially available materials, like film, spray, injectable hydrogel, powder, or solution type have been energetically studied based on natural and synthetic biomaterials such as alginate, hyaluronan, cellulose, starch, chondroitin sulfate, polyethylene glycol, polylactic acid, etc. Moreover, many kinds of animal adhesion models, such as cecum abrasion models and unitary horn models, are developed to evaluate new materials’ efficacy. A new animal adhesion model based on hepatectomy and conventional animal adhesion models is recently developed and a new adhesion barrier by this new model is also developed. In summary, many kinds of materials and animal models are studied; thus, it is quite important to overview this field's current progress. Here, PPA is reviewed in terms of the species of biomaterials and animal models and several problems to be solved to develop better antiadhesion materials in the future are discussed.

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Dual dynamically crosslinked thermosensitive hydrogel with self-fixing as a postoperative anti-adhesion barrier

Cited by 80 publications

References 51 publications

Anti-bacterial dynamic hydrogels prepared from O-carboxymethyl chitosan by dual imine bond crosslinking for biomedical applications

Anti-bacterial dynamic hydrogels prepared from O-carboxymethyl chitosan by dual imine bond crosslinking for biomedical applications

Ti₃C₂Tx MXenes reinforced PAA/CS hydrogels with self‐healing function as flexible supercapacitor electrodes

Advancement of Biomaterial‐Based Postoperative Adhesion Barriers

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Dual dynamically crosslinked thermosensitive hydrogel with self-fixing as a postoperative anti-adhesion barrier

Cited by 80 publications

References 51 publications

Anti-bacterial dynamic hydrogels prepared from O-carboxymethyl chitosan by dual imine bond crosslinking for biomedical applications

Anti-bacterial dynamic hydrogels prepared from O-carboxymethyl chitosan by dual imine bond crosslinking for biomedical applications

Ti3C2Tx MXenes reinforced PAA/CS hydrogels with self‐healing function as flexible supercapacitor electrodes

Advancement of Biomaterial‐Based Postoperative Adhesion Barriers

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Product

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Ti₃C₂Tx MXenes reinforced PAA/CS hydrogels with self‐healing function as flexible supercapacitor electrodes