Dual-functional core-shell electrospun mats with precisely controlled release of anti-inflammatory and anti-bacterial agents

Wen, Shihao; Hu, Yupeng; Zhang, Yuanzhong; Huang, Shifeng; Yu-chen, Zuo; Min, Younjin

doi:10.1016/j.msec.2019.02.076

Cited by 35 publications

(18 citation statements)

References 81 publications

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“…In the past few years, several research groups have prepared polymeric nanofibers in order to achieve different controlled drug release profiles. To date, various types of drugs, including DNA, RNA, protein, antibacterial, antiviral, and anticancer agents, etc., have been incorporated into electrospun nanofibers for desired applications [31,34,35,36]. For example, electrospun nanofibers have been applied as skin care (or facial) masks for the treatment of the skin as well as for other medical or therapeutic purposes.…”

Section: Biomedical Applications Of the Electrospun Nanofibersmentioning

confidence: 99%

Drug Delivery Applications of Core-Sheath Nanofibers Prepared by Coaxial Electrospinning: A Review

2019

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Electrospinning has emerged as one of the potential techniques for producing nanofibers. The use of electrospun nanofibers in drug delivery has increased rapidly over recent years due to their valuable properties, which include a large surface area, high porosity, small pore size, superior mechanical properties, and ease of surface modification. A drug loaded nanofiber membrane can be prepared via electrospinning using a model drug and polymer solution; however, the release of the drug from the nanofiber membrane in a safe and controlled way is challenging as a result of the initial burst release. Employing a core-sheath design provides a promising solution for controlling the initial burst release. Numerous studies have reported on the preparation of core-sheath nanofibers by coaxial electrospinning for drug delivery applications. This paper summarizes the physical phenomena, the effects of various parameters in coaxial electrospinning, and the usefulness of core-sheath nanofibers in drug delivery. Furthermore, this report also highlights the future challenges involved in utilizing core-sheath nanofibers for drug delivery applications.

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Section: Biomedical Applications Of the Electrospun Nanofibersmentioning

confidence: 99%

Drug Delivery Applications of Core-Sheath Nanofibers Prepared by Coaxial Electrospinning: A Review

2019

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“…By using coaxial electrospinning, Heydari et al [119] obtained an antibacterial and healing promotion coreshell membranes by loading simvastatin in the core and ciprofloxacin in the shell. Wen et al [123] also prepared a dual-functional core-shell electrospun mat with the ability to accurately control the release of anti-inflammatory and anti-bacterial agents.…”

Section: Wound Dressingmentioning

confidence: 99%

The Development and Bio-applications of Multifluid Electrospinning

Wang¹,

Yu²,

Li³

et al. 2020

MAHIG

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Electrospinning is a potent "top-down" nanofabrication method and has been explored by many researchers in recent decades because it is an efficient, versatile, simple, and low-cost route to prepare nanofibers. Nanofiber membranes generated by electrospinning have been used in various fields including tissue engineering, wound dressing, biosensing, theranostics, and functional textiles. Here we summarize the development of multifluid electrospinning processes, including coaxial, Janus and triaxial electrospinning, and the applications of these techniques. Complex nanostructures prepared by multifluid electrospinning are considered. The key parameters that affect the electrospinning process are introduced, and a discussion of both equipment and solution parameters is presented.

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“…Electrospun fibres provide matrices in which active compounds can be incorporated. Fibres with a core-shell structure fabricated via coaxial electrospinning can be loaded with a core of antimicrobial compounds [109,110], as well as corrosion inhibitors and self-healing agents [111]. The shell of the fibres will serve to protect and control the release.…”

Section: Release Of Active Compoundsmentioning

confidence: 99%

Electrospinning: A Powerful Tool to Improve the Corrosion Resistance of Metallic Surfaces Using Nanofibrous Coatings

Rivero

Redin

Rodríguez

2020

Metals

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The use of surface engineering techniques to tune-up the composition of nanostructured thin-films for developing functional coatings with advanced properties is a hot topic within the scientific community. The control of the coating structure at the nanoscale level allows improving the intrinsic properties of the surface compared to bulk materials. A nanodeposition technique with increasing popularity in the field of nanotechnology is electrospinning. This technique permits the fabrication of long and continuous fibres on the micro-nano scale. The good control over fibre morphology combined with its simplicity, cost-effectiveness, easy exploitability and scalability make electrospinning a very interesting tool for technological applications. This review is focused on the use of the electrospinning technique to protect metallic surfaces against corrosion. Polymeric precursors, from natural or biodegradable to synthetic polymers and copolymers can be electrospun with an adequate control of the operational deposition parameters (applied voltage, flow rate, distance tip to collector) and the intrinsic properties of the polymeric precursor (concentration, viscosity, solvent). The electrospun fibres can be used as an efficient alternative to encapsulate corrosion inhibitors of different nature (inorganic or organic) as well as self-healing agents which can be released to reduce the corrosion rate in the metallic surfaces.

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Dual-functional core-shell electrospun mats with precisely controlled release of anti-inflammatory and anti-bacterial agents

Cited by 35 publications

References 81 publications

Drug Delivery Applications of Core-Sheath Nanofibers Prepared by Coaxial Electrospinning: A Review

Drug Delivery Applications of Core-Sheath Nanofibers Prepared by Coaxial Electrospinning: A Review

The Development and Bio-applications of Multifluid Electrospinning

Electrospinning: A Powerful Tool to Improve the Corrosion Resistance of Metallic Surfaces Using Nanofibrous Coatings

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