2018
DOI: 10.1002/ange.201800148
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Dual‐Input Regulation and Positional Control in Hybrid Oligonucleotide/Discotic Supramolecular Wires

Abstract: The combination of oligonucleotides and synthetic supramolecular systems allows for novel and long‐needed modes of regulation of the self‐assembly of both molecular elements. Discotic molecules were conjugated with short oligonucleotides and their assembly into responsive supramolecular wires studied. The self‐assembly of the discotic molecules provides additional stability for DNA‐duplex formation owing to a cooperative effect. The appended oligonucleotides allow for positional control of the discotic element… Show more

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Cited by 8 publications
(3 citation statements)
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References 39 publications
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“…Addition of a solution of supramolecular Cy5‐disc 5 assemblies to the supramolecular polymers assembled on DNA origami produced a time‐dependent increase in FRET, but only when the Cy3 fluorophores were placed in close proximity to the supramolecular assembly (Figure 4; compare red curves in a and b). The FRET signal approaches equilibrium after 60 min, which corresponds to reported mixing kinetics between similar supramolecular assemblies, purely assembled in solution [8, 18] . No increase in FRET was observed when DNA‐disc 2 , anchoring the supramolecular polymer to the DNA, was omitted from multicomponent mixture, confirming the absence of nonspecific interactions with the DNA nanostructure (gray curves).…”
Section: Figuresupporting
confidence: 69%
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“…Addition of a solution of supramolecular Cy5‐disc 5 assemblies to the supramolecular polymers assembled on DNA origami produced a time‐dependent increase in FRET, but only when the Cy3 fluorophores were placed in close proximity to the supramolecular assembly (Figure 4; compare red curves in a and b). The FRET signal approaches equilibrium after 60 min, which corresponds to reported mixing kinetics between similar supramolecular assemblies, purely assembled in solution [8, 18] . No increase in FRET was observed when DNA‐disc 2 , anchoring the supramolecular polymer to the DNA, was omitted from multicomponent mixture, confirming the absence of nonspecific interactions with the DNA nanostructure (gray curves).…”
Section: Figuresupporting
confidence: 69%
“…The supramolecular system consists of bipyridine‐based C 3 ‐symmetrical amphiphilic discotic molecules that self‐assemble in water to form intrinsically fluorescent columnar aggregates, presumably via an isodesmic mechanism [18] . A library of differently functionalized monomers (Figure S1) includes fully glycol‐decorated monomer 1 (termed inert “disc”, due to the disc‐like molecular structure, Figure 1 a) and 1 a , with a single amine‐functionalization on one of the nine ethylene glycol tails as versatile starting point for the synthesis of other derivatives.…”
Section: Figurementioning
confidence: 99%
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