Dual lanthanide-doped complexes: the development of a time-resolved ratiometric fluorescent probe for anthrax biomarker and a paper-based visual sensor

Wang, Qi-Xian; Xue, Shi-Fan; Chen, Zi‐Han; Ma, Shihui; Zhang, Shengqiang; Shi, Guoyue; Zhang, Min

doi:10.1016/j.bios.2017.03.027

Cited by 157 publications

(57 citation statements)

References 22 publications

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“…The major advantages of fluorescence-based POC diagnostic platforms compared with colorimetric sensing methods are simplicity, high selectivity and sensitivity, low detection limits, fast response time, and ease of handling [164]. However, fluorescence-based sensors suffer from background excitation light interference, which may mislead the accuracy of the experiments.…”

Section: Fluorescence-based Aptasensors For Abused Drugsmentioning

confidence: 99%

A Bottom-Up Approach for Developing Aptasensors for Abused Drugs: Biosensors in Forensics

et al. 2019

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Aptamer-based point-of-care (POC) diagnostics platforms may be of substantial benefit in forensic analysis as they provide rapid, sensitive, user-friendly, and selective analysis tools for detection. Aptasensors have not yet been adapted commercially. However, the significance of the applications of aptasensors in the literature exceeded their potential. Herein, in this review, a bottom-up approach is followed to describe the aptasensor development and application procedure, starting from the synthesis of the corresponding aptamer sequence for the selected analyte to creating a smart surface for the sensitive detection of the molecule of interest. Optical and electrochemical biosensing platforms, which are designed with aptamers as recognition molecules, detecting abused drugs are critically reviewed, and existing and possible applications of different designs are discussed. Several potential disciplines in which aptamer-based biosensing technology can be of greatest value, including forensic drug analysis and biological evidence, are then highlighted to encourage researchers to focus on developing aptasensors in these specific areas.

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Section: Fluorescence-based Aptasensors For Abused Drugsmentioning

confidence: 99%

A Bottom-Up Approach for Developing Aptasensors for Abused Drugs: Biosensors in Forensics

et al. 2019

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“…Ratiometric measurement is an attractive property to measure due to its inherent ability to correct for environmental factors (such as varied lighting conditions and/or optical transparency of medium; especially useful on paper-based platforms) and to self-calibrate [ 52 , 53 ]. Fluorescent dyes, although have been popularly used to demonstrate FRET-based ratiometric assays, can be easily susceptible to photobleaching [ 54 ]. More recently, the use of quantum dots [ 53 , 55 , 56 ] and gold nanoclusters [ 21 ] have been more favorable choices for FRET-based sensors due to its photostability and superior intensity from background and undesired autofluorescence [ 57 ].…”

Section: Digital Processingmentioning

confidence: 99%

Challenges in paper-based fluorogenic optical sensing with smartphones

Ulep

Yoon

2018

Nano Convergence

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Application of optically superior, tunable fluorescent nanotechnologies have long been demonstrated throughout many chemical and biological sensing applications. Combined with microfluidics technologies, i.e. on lab-on-a-chip platforms, such fluorescent nanotechnologies have often enabled extreme sensitivity, sometimes down to single molecule level. Within recent years there has been a peak interest in translating fluorescent nanotechnology onto paper-based platforms for chemical and biological sensing, as a simple, low-cost, disposable alternative to conventional silicone-based microfluidic substrates. On the other hand, smartphone integration as an optical detection system as well as user interface and data processing component has been widely attempted, serving as a gateway to on-board quantitative processing, enhanced mobility, and interconnectivity with informational networks. Smartphone sensing can be integrated to these paper-based fluorogenic assays towards demonstrating extreme sensitivity as well as ease-of-use and low-cost. However, with these emerging technologies there are always technical limitations that must be addressed; for example, paper’s autofluorescence that perturbs fluorogenic sensing; smartphone flash’s limitations in fluorescent excitation; smartphone camera’s limitations in detecting narrow-band fluorescent emission, etc. In this review, physical optical setups, digital enhancement algorithms, and various fluorescent measurement techniques are discussed and pinpointed as areas of opportunities to further improve paper-based fluorogenic optical sensing with smartphones.

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“…Zhang et al designed a system for detecting an anthrax biomarker, dipicolinic acid (DPA), using lanthanide-doped silica NPs ( Figure 1 b) [ 22 ]. Some fluorescent probes have already been used to detect DPA.…”

Section: Lanthanide-doped Luminescent Nanoparticles For Diagnosticmentioning

confidence: 99%

“…HClO induces ratiometric luminescence quenching by releasing Eu ions from Eu-complex. Reprinted with permission from [ 20 , 22 , 42 ].…”

Section: Figurementioning

confidence: 99%

“…The weak luminescence intensity of lanthanide ions is not sufficient for highly sensitive detection. Therefore, to enhance the luminescence intensity, lanthanide ions are incorporated into host materials such as polymer beads [ 20 , 21 ], silica [ 22 ], and inorganic NPs [ 23 ]. Although bare NPs without any surface modification could be used for target detection [ 24 ], bioconjugation of NPs with target-specific moieties (e.g., proteins or nucleic acid) is commonly recommended to increase the sensitivity and specificity [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

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Lanthanide-Doped Nanoparticles for Diagnostic Sensing

et al. 2017

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Lanthanide-doped nanoparticles exhibit unique optical properties, such as a long luminescence lifetime (up to several milliseconds), sharp emission peaks, and upconversion luminescence over the range of wavelengths from near-infrared to visible. Exploiting these optical properties, lanthanide-doped nanoparticles have been widely utilized for cellular and small animal imaging with the absence of background autofluorescence. In addition, these nanoparticles have advantages of high signal-to-noise ratio for highly sensitive and selective diagnostic detection. In this review, we summarize and discuss recent progress in the development of highly sensitive diagnostic methods using lanthanide-doped nanoparticles. Combined with a smartphone, portable luminescence detecting platforms could be widely applied in point-of-care tests.

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Dual lanthanide-doped complexes: the development of a time-resolved ratiometric fluorescent probe for anthrax biomarker and a paper-based visual sensor

Cited by 157 publications

References 22 publications

A Bottom-Up Approach for Developing Aptasensors for Abused Drugs: Biosensors in Forensics

A Bottom-Up Approach for Developing Aptasensors for Abused Drugs: Biosensors in Forensics

Challenges in paper-based fluorogenic optical sensing with smartphones

Lanthanide-Doped Nanoparticles for Diagnostic Sensing

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