Dual‐Mode Nanoparticle Probes for High‐Performance Magnetic Resonance and Fluorescence Imaging of Neuroblastoma

Lee, Jae-Hyun; Jun, Young‐wook; Yeon, Soo-In; Shin, Jeon-Soo; Cheon, Jinwoo

doi:10.1002/ange.200603052

Cited by 76 publications

(38 citation statements)

References 24 publications

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“…Fe 3 O 4 MNS have been assembled on dye-doped mesoporous silica nanoparticles (Fig. 10a) [37, 150]. The r 2 value of Fe 3 O 4 coated silica nanoparticles was 2.8 times higher than that of well-dispersed Fe 3 O 4 nano-particles (Fig.…”

Section: Mns For Diagnostic Imaging Of Cancermentioning

confidence: 99%

Theranostic Magnetic Nanostructures (MNS) for Cancer

Nandwana

Chu³

et al. 2015

Cancer Treatment and Research

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Despite the complexities of cancer, remarkable diagnostic and therapeutic advances have been made during the past decade, which include improved genetic, molecular, and nanoscale understanding of the disease. Physical science and engineering, and nanotechnology in particular, have contributed to these developments through out-of-the-box ideas and initiatives from perspectives that are far removed from classical biological and medicinal aspects of cancer. Nanostructures, in particular, are being effectively utilized in sensing/diagnostics of cancer while nanoscale carriers are able to deliver therapeutic cargo for timed and controlled release at localized tumor sites. Magnetic nanostructures (MNS) have especially attracted considerable attention of researchers to address cancer diagnostics and therapy. A significant part of the promise of MNS lies in their potential for “theranostic” applications, wherein diagnostics makes use of the enhanced localized contrast in magnetic resonance imaging (MRI) while therapy leverages the ability of MNS to heat under external radio frequency (RF) field for thermal therapy or use of thermal activation for release of therapy cargo. In this chapter, we report some of the key developments in recent years in regard to MNS as potential theranostic carriers. We describe that the r2 relaxivity of MNS can be maximized by allowing water (proton) diffusion in the vicinity of MNS by polyethylene glycol (PEG) anchoring, which also facilitates excellent fluidic stability in various media and extended in vivo circulation while maintaining high r2 values needed for T2-weighted MRI contrast. Further, the specific absorption rate (SAR) required for thermal activation of MNS can be tailored by controlling composition and size of MNS. Together, emerging MNS show considerable promise to realize theranostic potential. We discuss that properly functionalized MNS can be designed to provide remarkable in vivo stability and accompanying pharmacokinetics exhibit organ localization that can be tailored for specific applications. In this context, even iron-based MNS show extended circulation as well as diverse organ accumulation beyond liver, which otherwise renders MNS potentially toxic to liver function. We believe that MNS, including those based on iron oxides, have entered a renaissance era where intelligent synthesis, functionalization, stabilization, and targeting provide ample evidence for applications in localized cancer theranostics.

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Section: Mns For Diagnostic Imaging Of Cancermentioning

confidence: 99%

Theranostic Magnetic Nanostructures (MNS) for Cancer

Nandwana

Chu³

et al. 2015

Cancer Treatment and Research

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“…So wurde über "Kern-Satelliten"-Hybridnanopartikel aus einem farbstoffdotierten Siliciumdioxid-Kern (Dye-SiO 2 ) und mehreren Fe 3 O 4 -Nanopartikeln berichtet. [94] Aufgrund kooperativer magnetischer Wechselwirkungen zwischen den gekoppelten Nanopartikeln ist der Kontrasteffekt dieser Sonden um den Faktor 3.4 größer als bei den isolierten Nanopartikeln (Abbildung 16 a). Mit NanopartikelKonjugaten des HmenB1-Antikörpers, der spezifisch an Polysialinsäure bindet, werden PSA-positive Zellen (CHP-134) in Kernspintomographien dunkel wiedergegeben und sind anhand dieses Kontrasts nachweisbar (Abbildung 16 b).…”

Section: Angewandte Chemieunclassified

Chemisches Design von leistungsfähigen Nanosonden für die Kernspintomographie

2008

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Synthetische magnetische Nanopartikel (MNP) werden in der Biomedizin immer häufiger als Sonden eingesetzt. Dies gilt besonders für die Anwendung in der Kernspintomographie (Magnetic Resonance Imaging, MRI). Diese Nanopartikel sind von ähnlicher Größe wie biologische Funktionseinheiten. Deshalb und wegen ihrer einzigartigen magnetischen Eigenschaften eignen sie sich zur molekularen Bildgebung. Dieser Aufsatz gibt einen Überblick zu neuartigen MNP‐Sonden, mit denen biologische Ereignisse auf molekularer und zellulärer Ebene empfindlich und spezifisch nachgewiesen werden können.

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“…[3,6] Furthermore, delivery of the bifunctional nanostructures in a targeted manner could be achieved by applying an external magnetic field. [7] Several fluorophores have been investigated for the preparation of bifunctional magnetic fluorescent nanostructures, a great majority of which employed organic dyes [8][9] and semiconductor quantum dots (QDs) [10][11][12] as the emitting component. Organic dyes are commonly used because they have been widely used as fluorescent labeling agents.…”

Section: Introductionmentioning

confidence: 99%

“…[8][9][10][11][12] On top of the biocompatibility, SPIONs are selected because they have been extensively studied for various biomedical applications, such as hypherthermia, magnetic guided drug delivery, cell sorting, protein immobilization, and contrast agents in MRI. [27] To integrate the fluorescence and magnetism functionalities into a single nanoobject, several different synthetic strategies have been devised over the past few years, which can be broadly classified into: 1) covalent conjugation of the fluorophores onto magnetic nanocrystals by small organic molecules, [28][29] 2) direct bonding between the fluorophores and magnetic nanocrystals through inorganic synthesis, [30][31] and 3) coencapsulation of both fluorescent and magnetic components inside polymeric [10][11][12] or silica nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Silica Nanocapsules of Fluorescent Conjugated Polymers and Superparamagnetic Nanocrystals for Dual‐Mode Cellular Imaging

Tan

Wang²,

Yang

et al. 2011

Chemistry A European J

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We describe here a facile and benign synthetic strategy to integrate the fluorescent behavior of conjugated polymers and superparamagnetic properties of iron oxide nanocrystals into silica nanocapsules, forming a new type of bifunctional magnetic fluorescent silica nanocapsule (BMFSN). The resultant BMFSNs are uniform, colloidally stable in aqueous medium, and exhibit the desired dual functionality of fluorescence and superparamagnetism in a single entity. Four conjugated polymers with different emissions were used to demonstrate the versatility of employing this class of fluorescent materials for the preparation of BMFSNs. The applicability of BMFSNs in cellular imaging was studied by incubating them with human liver cancer cells, the result of which demonstrated that the cells could be visualized by dual-mode fluorescence and magnetic resonance imaging. Furthermore, the superparamagnetic behavior of the BMFSNs was exploited for in vitro magnetic-guided delivery of the nanocapsules into the cancer cells, thereby highlighting their potential for targeting biomedical applications.

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Dual‐Mode Nanoparticle Probes for High‐Performance Magnetic Resonance and Fluorescence Imaging of Neuroblastoma

Cited by 76 publications

References 24 publications

Theranostic Magnetic Nanostructures (MNS) for Cancer

Theranostic Magnetic Nanostructures (MNS) for Cancer

Chemisches Design von leistungsfähigen Nanosonden für die Kernspintomographie

Silica Nanocapsules of Fluorescent Conjugated Polymers and Superparamagnetic Nanocrystals for Dual‐Mode Cellular Imaging

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