2024
DOI: 10.1002/chem.202401589
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Dual pH and Ca2+‐Responsive PEG‐Modified Pillar[5]arene‐Based Supramolecular Nanodrug Delivery System: Excellent Cargo Encapsulation and Minimal Drug Toxicity

Haojie Shao,
Wengui Duan,
Yan Huang
et al.

Abstract: Chemotherapy is one of the most employed strategies in clinical treatment of cancer. However, reducing medication adverse effects and improving the biological activity remains a significant issue for chemotherapy. We developed a pH and Ca2+‐responsive pillar[5]arene‐based supramolecular nanodrug delivery system (NDDS) WP5⊃EV@DOX to address the aforementioned challenges. The formation of this NDDS began with the spontaneous formation of supramolecular nanodrug carrier WP5⊃EV in water from PEG‐modified pillar[5]… Show more

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