Dual response to pH and chiral microenvironments for the release of a flurbiprofen-loaded chiral self-assembled mesoporous silica drug delivery system

Wu, Lulu; Gou, Kaijun; Guo, Xianmou; Guo, Yingyu; Chen, Muyun; Hou, Jing; Li, Sanming; Li, Heran

doi:10.1016/j.colsurfb.2020.111501

Cited by 16 publications

(8 citation statements)

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“…Nimesulide is commonly used for pain relieving in painful osteoarthritis disorders and other acute pain states [ 113 , 114 ]. Another drug often used to relief pain and inflammation symptoms in osteoarthritis and rheumatoid arthritis is flurbiprofen [ 115 , 116 ]. The mechanism of action of this phenylalcanoic acid derivative belonging to the group of NSAIDS also involves blockage of the COX-2 enzyme.…”

Section: Anti-inflammatory Agentsmentioning

confidence: 99%

“…Mesoporous silica-based DDSs are especially useful for the incorporation of poorly water-soluble drug molecules. In order to solve the problem of low solubility, many different approaches have been put forward and investigated in depth to improve the dissolution kinetics and bioavailability of poorly water-soluble drugs such as solid dispersions, nanosuspensions, spray drying, cryogenic technologies and prodrug strategies [ 87 , 115 , 155 ]. It was shown that the problem of low drug solubility can also be overcome by the usage of a carrier substance like mesoporous silica during the preparation of sophisticated drug delivery platforms.…”

Section: Mesoporous Material-based Drug Delivery Systems For Anti-inf...mentioning

confidence: 99%

“…Well-defined surface of mesoporous matrices allows conjunction with pore-blocking materials to prevent premature cargo release, with stimuli-responsive ligands (nanovalves or gate keepers [ 145 ]) for controlled release or with specific ligands for targeting [ 151 ]. Stimuli-responsive drug release refers to the release of the drug trigged by a variety of external factors including temperature, light, pH, heat, tumors, enzyme presence, chiral environment or redox potential [ 115 , 161 , 162 ]. These approaches were shown to improve the therapeutic efficacy and reduce side effects of the drugs which is of great importance in pharmaceutical practice and can lift DDSs research to a new level.…”

Section: Mesoporous Material-based Drug Delivery Systems For Anti-inf...mentioning

confidence: 99%

“…One outstanding feature resulting from the usage of mesoporous silica as the carrier in modern drug delivery platforms is the enhancement of dissolution kinetics and bioavailability of poorly water-soluble drugs. It is claimed that over 70% of active pharmaceutical ingredients (APIs) belong to the Biopharmaceutical Classification System (BCS) class II and IV [ 87 , 115 ]. The substances from class II are characterized by low solubility and high permeability through biological membranes (intestinal epithelium) meanwhile the components of class IV exhibit both low solubility and low permeability [ 161 ].…”

Section: Mesoporous Material-based Drug Delivery Systems For Anti-inf...mentioning

confidence: 99%

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Mesoporous Materials as Elements of Modern Drug Delivery Systems for Anti-Inflammatory Agents: A Review of Recent Achievements

Moritz

Geszke-Moritz

2022

Pharmaceutics

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Interest in the use of mesoporous materials as carriers of medicinal substances has been steadily increasing in the last two decades. Mesoporous carriers have application in the preparation of delivery systems for drugs from various therapeutic groups; however, their use as the carriers of anti-inflammatory agents is particularly marked. This review article, with about 170 references, summarizes the achievements in the application of mesoporous materials as the carriers of anti-inflammatory agents in recent years. This article will discuss a variety of mesoporous carriers as well as the characteristics of their porous structure that determine further use of these materials in the field of medical applications. Special attention will be paid to the progress observed in the construction of stimuli-responsive drug carriers and systems providing site-specific drug delivery. Subsequently, a review of the literature devoted to the use of mesoporous matrices as the carriers of anti-inflammatory drugs was carried out.

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Section: Anti-inflammatory Agentsmentioning

confidence: 99%

Section: Mesoporous Material-based Drug Delivery Systems For Anti-inf...mentioning

confidence: 99%

Section: Mesoporous Material-based Drug Delivery Systems For Anti-inf...mentioning

confidence: 99%

Section: Mesoporous Material-based Drug Delivery Systems For Anti-inf...mentioning

confidence: 99%

See 2 more Smart Citations

Mesoporous Materials as Elements of Modern Drug Delivery Systems for Anti-Inflammatory Agents: A Review of Recent Achievements

Moritz

Geszke-Moritz

2022

Pharmaceutics

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“…Naturally, applying chirality definition into MSNs, chiral mesoporous silica (CMS) has been proposed and have been of significant interest in a variety of fields. Notably, the bold attempt of applying CMSs as drug carriers in recent years has brought unlimited possibilities due to the beneficial property of chiral materials (Wu et al, 2021). Previous reports point out that CMS has several interesting features, such as chiral topological structure (in molecular level, supramolecular level or macroscopic level), interconnection between individual porous channels, high external surface area and potential chiral recognition functions (Wang et al, 2019;Gou et al, 2020a,b).…”

Section: Introductionmentioning

confidence: 99%

Facile synthesis of PEI-based crystalline templated mesoporous silica with molecular chirality for improved oral delivery of the poorly water-soluble drug

et al. 2021

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The aim of this study was to build up a novel chiral mesoporous silica called PEIs@TA-CMS through a facile biomimetic strategy and to explore its potential to serve as a drug carrier for improving the delivery efficiency of poorly water-soluble drug. PEIs@TA-CMS was synthesized by using a chiral crystalline complex associated of tartaric acid and polyethyleneimine (PEIs) as templates, scaffolds and catalysts. The structural features including morphology, size, pore structure and texture properties were systematacially studied. The results showed that PEIs@TA-CMS was monodispersed spherical nanoparticles in a uniformed diameter of 120–130 nm with well-developed pore structure (S BET : 1009.94 m 2 /g, pore size <2.21 nm). Then PEIs@TA-CMS was employed as nimodipine (NMP) carrier and compared with the drug carry ability of MCM41. After drug loading, NMP was effectively transformed from the crystalline state to an amorphous state due to the space confinement in mesopores. As expected, PEIs@TA-CMS had superiority in both drug loading and drug release compared to MCM41. It could incorporate NMP with high efficiency, and the dissolution-promoting effect of PEIs@TA-CMS was more obvious because of the unique interconnected curved pore channels. Meanwhile, PEIs@TA-CMS could significantly improve the oral adsorption of NMP to a satisfactory level, which showed approximately 3.26-fold higher in bioavailability, and could effectively prolong the survival time of mice on cerebral anoxia from 10.98 to 17.33 min.

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Custom‐Design of Multi‐Stimuli‐Responsive Degradable Silica Nanoparticles for Advanced Cancer‐Specific Chemotherapy

Zhang,

Zhou,

Tang

et al. 2024

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Chemotherapy is crucial in oncology for combating malignant tumors but often encounters obatacles such as severe adverse effects, drug resistance, and biocompatibility issues. The advantages of degradable silica nanoparticles in tumor diagnosis and treatment lie in their ability to target drug delivery, minimizing toxicity to normal tissues while enhancing therapeutic efficacy. Moreover, their responsiveness to both endogenous and exogenous stimuli opens up new possibilities for integrating multiple treatment modalities. This review scrutinizes the burgeoning utility of degradable silica nanoparticles in combination with chemotherapy and other treatment modalities. Commencing the elucidation of degradable silica synthesis and degradation mechanisms, emphasis is placed on the responsiveness of these materials to endogenous (e.g., pH, redox reactions, hypoxia, and enzymes) and exogenous stimuli (e.g., light and high‐intensity focused ultrasound). Moreover, this exploration delves into strategies harnessing degradable silica nanoparticles in chemotherapy alone, coupled with radiotherapy, photothermal therapy, photodynamic therapy, gas therapy, immunotherapy, starvation therapy, and chemodynamic therapy, elucidating multimodal synergies. Concluding with an assessment of advances, challenges, and constraints in oncology, despite hurdles, future investigations are anticipated to augment the role of degradable silica in cancer therapy. These insights can serve as a compass for devising more efficacious combined tumor treatment strategies.

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Dual response to pH and chiral microenvironments for the release of a flurbiprofen-loaded chiral self-assembled mesoporous silica drug delivery system

Cited by 16 publications

References 58 publications

Mesoporous Materials as Elements of Modern Drug Delivery Systems for Anti-Inflammatory Agents: A Review of Recent Achievements

Mesoporous Materials as Elements of Modern Drug Delivery Systems for Anti-Inflammatory Agents: A Review of Recent Achievements

Facile synthesis of PEI-based crystalline templated mesoporous silica with molecular chirality for improved oral delivery of the poorly water-soluble drug

Custom‐Design of Multi‐Stimuli‐Responsive Degradable Silica Nanoparticles for Advanced Cancer‐Specific Chemotherapy

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