Dual-Responsive Micellar Microgels Matrixed with Surface-Engineered Lipids: a New Approach for Controlled Vaginal Drug Delivery

Kenechukwu, Franklin Chimaobi; Momoh, Mumuni A.; Nnamani, Petra O.; Umeyor, Chukwuebuka; Uronnachi, Emmanuel; Dias, Marcos L.; Ibezim, EC; Attama, Anthony A.

doi:10.1007/s12247-021-09546-5

Cited by 2 publications

(1 citation statement)

References 41 publications

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“…Therefore, higher melting enthalpy values would suggest a higher ordered lattice arrangement [ 46 ]. The slight presence or total absence of a melting peak in the DSC of a pharmaceutical formulation indicates that the drug is partly or completely amorphous/molecularly dispersed [ 47 , 48 ]. Metformin and Phospholipon® 90H thermograms showed a single sharp endothermic peak at 265.5 and 122.1 °C with enthalpy of -28.4 and -38.9 mW/mg, respectively, corresponding to their melting points, an indication of the highly crystalline nature of these materials.…”

Section: Resultsmentioning

confidence: 99%

Potential enhancement of metformin hydrochloride in solidified reverse micellar solution-based PEGylated lipid nanoparticles targeting therapeutic efficacy in diabetes treatment

Kenechukwu

Nnamani

Duhu

et al. 2022

Heliyon

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Section: Resultsmentioning

confidence: 99%

Potential enhancement of metformin hydrochloride in solidified reverse micellar solution-based PEGylated lipid nanoparticles targeting therapeutic efficacy in diabetes treatment

Kenechukwu

Nnamani

Duhu

et al. 2022

Heliyon

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Molecular association of Candida albicans and vulvovaginal candidiasis: focusing on a solution

David,

Solomon

2023

Front. Cell. Infect. Microbiol.

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Candida albicans-mediated vulvovaginal candidiasis (VVC) is a significant challenge in clinical settings, owing to the inefficacy of current antifungals in modulating virulence, development of resistance, and poor penetration into the biofilm matrix. Various predisposition factors are molecular drivers that lead to the dysbiosis of normal microflora of the vagina, upregulation of central metabolic pathways, morphogenesis, hyphal extension, adhesion, invasion, and biofilm formation leading to chronic infection and recurrence. Hence, it is crucial to understand the molecular mechanism behind the virulence pathways driven by those drivers to decode the drug targets. Finding innovative solutions targeting fungal virulence/biofilm may potentiate the antifungals at low concentrations without affecting the recurrence of resistance. With this background, the present review details the critical molecular drivers and associated network of virulence pathways, possible drug targets, target-specific inhibitors, and probable mode of drug delivery to cross the preclinical phase by appropriate in vivo models.

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Dual-Responsive Micellar Microgels Matrixed with Surface-Engineered Lipids: a New Approach for Controlled Vaginal Drug Delivery

Cited by 2 publications

References 41 publications

Potential enhancement of metformin hydrochloride in solidified reverse micellar solution-based PEGylated lipid nanoparticles targeting therapeutic efficacy in diabetes treatment

Potential enhancement of metformin hydrochloride in solidified reverse micellar solution-based PEGylated lipid nanoparticles targeting therapeutic efficacy in diabetes treatment

Molecular association of Candida albicans and vulvovaginal candidiasis: focusing on a solution

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