Dual role for microbial short-chain fatty acids in modifying SIV disease trajectory following anti-α4β7 antibody administration
Samuel D. Johnson,
Nageswara Pilli,
Jianshi Yu
et al.
Abstract:Background
Human Immunodeficiency Virus (HIV)/Simian Immunodeficiency Virus (SIV) infection is associated with significant gut damage, similar to that observed in patients with inflammatory bowel disease (IBD). This pathology includes loss of epithelial integrity, microbial translocation, dysbiosis, and resultant chronic immune activation. Additionally, the levels of all-
trans
-retinoic acid (atRA) are dramatically attenuated. Data on the therapeutic use of anti-α4β7 an… Show more
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