Dual role of carboxylic acid additive: mechanistic studies and implication for the asymmetric C–H amidation

Mechanistic Studies on Rhodium-Catalyzed Enantioselective Silylation of Aryl C–H Bonds

“…This work constitutes a rare systematic mechanistic study on enantioselective C–H bond functionalization 41–44 and the first on the enantioselective functionalization of C–H bonds with main group reagents. By conducting a combination of experimental and theoretical studies, we elucidated the enantioselectivity-determining steps and the origin of the high enantioselectivity.…”

Directing‐Group‐Assisted Transition‐Metal‐Catalyzed Direct Intermolecular C−H Amidation and Amination of Arenes

“…Up to 90 % diastereomeric excess was obtained for the P‐chirogenic product. Furthermore, with the assistance of a chiral acid additive, they rendered the first real enantioselective catalytic C−H amidation of arylphosphoryl compound with sulfonyl azide, albeit with moderate enantioselectivity . It was still a promising guide to spur future research efforts especially in asymmetric C−H functionalization.…”

Pd-catalyzed enantioselective C–H arylation of phosphinamides with boronic acids for the synthesis of P-stereogenic compounds

“…The most commonly used methods for the preparation of Pstereogenic molecules have mainly relied on resolution, [24][25][26] chiral-auxiliary-aided asymmetric synthesis, [27][28][29][30][31][32][33][34] and asymmetric lithiation-trapping reactions. [35][36][37][38] Other alternative methods include the NHC-catalyzed desymmetrization of bisphenolic phosphinates, 39 the metal-catalyzed asymmetric cross-coupling of phosphines or phosphine oxides, [40][41][42][43][44][45] hydrophosphination of olefins, 46 addition reactions of phosphorus nucleophiles, 47,48 and olefin metathesis of divinyl phosphinates.…”