2022
DOI: 10.21203/rs.3.rs-1491454/v1
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

Dual Specificity Phosphatase 1 (DUSP1) Provides Mechanistic Link Between Melanoma Cellular Plasticity and Drug Resistance

Abstract: Melanoma cells exhibit phenotypic plasticity that allows transition from a proliferative and differentiated phenotype to a more invasive and undifferentiated or transdifferentiated phenotype often also associated with drug resistance. The mechanisms involved in melanoma phenotype plasticity and its role in drug resistance are not fully understood. We previously demonstrated that the MAPK inhibitors (MAPKi)-resistance phenotype is associated with decreased expression of stem cell proliferation genes and increas… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Publication Types

Select...

Relationship

0
0

Authors

Journals

citations
Cited by 0 publications
references
References 44 publications
(62 reference statements)
0
0
0
Order By: Relevance

No citations

Set email alert for when this publication receives citations?