Dual stimuli-responsive multi-drug delivery system for the individually controlled release of anti-cancer drugs

Wang, Xiao; Zhang, Xuan; Lin, Hang; Han, Kai; Jia, Hui‐Zhen; Zhang, Xian‐Zheng

doi:10.1039/c4cc08831j

Cited by 86 publications

(61 citation statements)

References 27 publications

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“…[4][5][6] In this case, stimuli-responsive polymers provide a solid platform for constructing different cocktail drugs loaded nanomedicines (e.g., hydrophobic and hydrophilic drugs), which exhibit "on-demand" drug release profiles and combination cytotoxicity. [7][8][9] Therefore polymeric nanotechnology might further enhance antitumor efficacy of cocktail chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Plasmonic, Targeted, and Dual Drugs-Loaded Polypeptide Composite Nanoparticles for Synergistic Cocktail Chemotherapy with Photothermal Therapy

Zhou

et al. 2016

Biomacromolecules

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To integrate cocktail chemotherapy with photothermal therapy into one biocompatible and biodegradable nanocarrier, the plasmonic, lactose-targeted, and dual anticancer drugs-loaded polypeptide composite nanoparticles were for the first time fabricated under mild conditions. The glyco-PEGylated polypeptide micelles that self-assembled from the lactose (LAC) and PEG grafted polycysteine terpolymer were used as templates to generate the plasmonic composite nanoparticles, as mainly characterized by DLS, TEM, SEM, and XPS. These composite nanoparticles showed a broad and strong near-infrared (NIR) absorption at 650-1100 nm and increased the temperature of phosphate buffer solution by 30.1 °C upon a continuous-wave laser irradiation (808 nm, 5 min, 2 W·cm(-2)), while the same dose of NIR-mediated heating completely killed HepG2 cancer cells in vitro, presenting excellent photothermal properties. Two anticancer drugs, doxorubicin (DOX) and 6-mercaptopurine (6-MP), were loaded into the composite nanoparticles through physical interactions and Au-S bond, respectively. The dual drugs-loaded composite nanoparticles exhibited reduction-sensitive and NIR-triggered cocktail drugs release profiles and trigger-enhanced cytotoxicity. As evidenced by flow cytometry, fluorescence microscopy, and MTT assay, the LAC-coated composite nanoparticles were more internalized by the HepG2 than the HeLa cell line, demonstrating a LAC-targeting enhanced cytotoxicity toward HepG2. The combination cocktail chemo-photothermal therapy produced a lower half maximal inhibitory concentration than cocktail chemotherapy or photothermal therapy alone, displaying a good synergistic antitumor effect.

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Section: Introductionmentioning

confidence: 99%

Plasmonic, Targeted, and Dual Drugs-Loaded Polypeptide Composite Nanoparticles for Synergistic Cocktail Chemotherapy with Photothermal Therapy

Zhou

et al. 2016

Biomacromolecules

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“…Sequential or combinatorial release of multiple therapies is incredibly promising, especially in the areas of chemotherapy (usually exploiting small molecule drugs) [ 89–91 ] and directing local tissue response to biomaterials (usually proteins). [ 92,93 ] In a recent example, combinatorial delivery of neurotrophic factor‐3 and glial‐cell derived neurotrophic factor was found to improve healing following spinal cord injury.…”

Section: Perspectivesmentioning

confidence: 99%

Visible Light‐Responsive Dynamic Biomaterials: Going Deeper and Triggering More

Rapp

DeForest

2020

Adv Healthcare Materials

100

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Photoresponsive materials have been widely used in vitro for controlled therapeutic delivery and to direct 4D cell fate. Extension of the approaches into a bodily setting requires use of low‐energy, long‐wavelength light that penetrates deeper into and through complex tissue. This review details recent reports of photoactive small molecules and proteins that absorb visible and/or near‐infrared light, opening the door to exciting new applications in multiplexed and in vivo regulation.

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“…Combination (or multi-drug) anti-cancer therapy, for example, has become popular as a route to overcoming drug resistance, with ideal "cocktail therapies" capable of controlled release of each drug individually to maximise synergistic effects. [98] Acidic and mildly hyperthermic microenvironments of cancerous tissues could also be exploited as dual triggers for the targeted delivery of therapeutics directly at a site of disease. There has hence been a surge of research in the area of multi-responsive Pickering emulsions in the last 5 years for various applications, including industrially relevant processes such as catalysis and sensing.…”

Section: Multi-stimuli Responsive Pickering Emulsionsmentioning

confidence: 99%

Recent developments in Pickering emulsions for biomedical applications

Harman

Patel

Guldin

et al. 2019

Current Opinion in Colloid & Interface Science

141

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Pickering emulsions, stabilised by organic or inorganic particles, offer long-term dispersibility of liquid droplets and resistance to coalescence. The versatility of stabilising particles and their ability to encapsulate and release cargo with high internal payload capacity makes them attractive in a wide variety of applications, ranging from catalysis to the cosmetic and food industry. While these properties make them an equally promising material platform for pharmaceutical and clinical applications, the development of Pickering emulsions for healthcare is still in its infancy. Herein, we summarise and discuss recent progress in the development of Pickering emulsions for biomedical applications, probing their design for passive diffusion-based release as well as stimuli-responsive destabilisation. We further comment on challenges and future directions of this exciting and rapidly expanding area of research.Pickering emulsions have been applied in a number of areas of research and industrial importance, such as food manufacturing, cosmetics, agrochemicals and therapeutic delivery. Their popularity in biomedical applications (i.e. for use in healthcare, such as therapeutics, diagnostics or imaging), in particular, has increased dramatically in recent years, thanks to their high stability, capacity for superior cargo loading compared to conventional systems, and diverse range of stabilising particles, creating a broad library of available building blocks. For biomedical and pharmaceutical application, the choice of emulsifier is critical; it must be biocompatible, non-toxic, and be able to be excreted from the body (if necessary). In this article, we will review the latest developments in the design and application of Pickering emulsions for biomedicine, with a focus on stimuli-responsive Pickering emulsions as a route to the triggered release of a payload towards advanced therapeutic delivery strategies. Within this discussion, we will describe systems which have been applied in proof of concept and in vitro assessments and emphasise areas of potential future development.

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Dual stimuli-responsive multi-drug delivery system for the individually controlled release of anti-cancer drugs

Cited by 86 publications

References 27 publications

Plasmonic, Targeted, and Dual Drugs-Loaded Polypeptide Composite Nanoparticles for Synergistic Cocktail Chemotherapy with Photothermal Therapy

Plasmonic, Targeted, and Dual Drugs-Loaded Polypeptide Composite Nanoparticles for Synergistic Cocktail Chemotherapy with Photothermal Therapy

Visible Light‐Responsive Dynamic Biomaterials: Going Deeper and Triggering More

Recent developments in Pickering emulsions for biomedical applications

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