Dual stimuli-responsive polymeric nanoparticles combining soluplus and chitosan for enhanced breast cancer targeting

Twal, Shrouq; Jaber, Nisrein; Al-Remawi, Mayyas; Hamad, Islam; Al-Akayleh, Faisal; Alshaer, Walhan

doi:10.1039/d3ra08074a

Cited by 9 publications

(2 citation statements)

References 93 publications

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“…There was an initial weight loss in the curves from 20 to 100 °C, which is due to the loss of absorbed water. The second stage of weight loss was monitored due to decomposition of the polymer when the temperature increased to 210 °C …”

Section: Resultsmentioning

confidence: 99%

“…The second stage of weight loss was monitored due to decomposition of the polymer when the temperature increased to 210 °C. 28 Arylboronic acid could be oxidized by ROS (such as H 2 O 2 ) and then rearranged to remove the modified group (Figure 2D). The H 2 O 2 -triggered removal of PBA groups from GC-PBA was investigated by 1 H NMR.…”

Section: Synthesis and Characterization Of Nbc Gc-pba And Fa-gc-pbamentioning

confidence: 99%

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Folate-Modified pH and ROS Dual-Responsive Polymeric Nanocarriers for Targeted Anticancer Drug Delivery

Dai,

Chen,

Zhang

et al. 2024

ACS Appl. Nano Mater.

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The tumor microenvironment is distinguished from normal tissues, such as the acidic microenvironment, elevated reactive oxygen species (ROS) levels, and overexpressed specific receptors on the cell surface. According to these unique hallmarks of cancer, stimulus-responsive drug carriers can be designed for targeted anticancer drug delivery and specific drug release in tumor tissues. Herein, a folate-modified pH/ROS dual-responsive polymeric micellar nanosystem was developed for the targeted delivery of doxorubicin (DOX). The drug release profile suggested a sustained drug release from the polymeric micelles and an accelerated drug release at lower pH and higher ROS levels. The cellular uptake assay indicated that the polymeric micelles were internalized by HepG2 cells and that the cellular uptake of micelles can be enhanced by folate modification through a receptor-mediated endocytosis pathway. Furthermore, the folate-modified pH/ ROS dual-responsive polymeric micellar nanocarriers demonstrated enhanced inhibition on the migration of HepG2 cells in the cell scratch test and showed improved suppression on the proliferation of HepG2 cells and a lower IC 50 than the nonfolate micelles in the cell viability test, indicating the desirable in vitro anticancer efficiency of the nanosystem.

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Section: Resultsmentioning

confidence: 99%

Section: Synthesis and Characterization Of Nbc Gc-pba And Fa-gc-pbamentioning

confidence: 99%