Dual-stream cortical feedbacks mediate sensory prediction

Abstract

Predictions are constantly generated from diverse sources to optimize cognitive functions in the ever-changing environment. However, the neural origin and generation process of top-down induced prediction remain elusive. We hypothesized that motor-based and memory-based predictions are mediated by distinct feedback networks from motor and memory systems to the sensory cortices. Using fMRI and a dual imagery paradigm, we showed that motor and memory upstream systems excited the auditory cortex in a content-specific manner. Moreover, the inferior and posterior parts of the parietal lobe differentially relayed predictive signals in motor-to-sensory and memory-to-sensory networks. Our results reveal the functionally distinct neural networks that mediate top-down sensory prediction and ground the neurocomputational basis of predictive processing.

Impaired motor-to-sensory transformation mediates auditory hallucinations

“…For example, actioninduced enhancement has been found in a subset of sensory cortices in addition to action-induced suppression (Eliades & Wang, 2005Enikolopov et al, 2018;Flinker et al, 2010;Singla et al, 2017). Auditory neural representations are constructed in auditory working memory based on covert speaking (Chu et al, 2022;Tian et al, 2018). This motor-based auditory working memory (i.e.…”