Dual target deep brain stimulation for complex essential and dystonic tremor – A 5-year follow up

Shepherd, Hilary; Heartshorne, Rosie; Osman-Farah, Jibril; Macerollo, Antonella

doi:10.1016/j.jns.2024.122887

Journal of the Neurological Sciences

2024

DOI: 10.1016/j.jns.2024.122887

|View full text |Cite

Dual target deep brain stimulation for complex essential and dystonic tremor – A 5-year follow up

Hilary Shepherd,

Rosie Heartshorne,

Jibril Osman-Farah

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Preprint1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Mapping the topographic organization of the human zona incerta using diffusion MRI

Haast,

Kai,

Taha

et al. 2024

Preprint

View full text Add to dashboard Cite

The zona incerta (ZI) is a deep brain region originally described by Auguste Forel as an “immensely confusing area about which nothing can be said.” Despite the elusive nature of this structure, mounting evidence supports the role of the ZI and surrounding regions across a diverse range of brain functions and as a candidate target for neuromodulatory therapies. Usingin vivodiffusion MRI and data-driven connectivity, we identify a topographic organization between the ZI and neocortex. Specifically, our methods identify a rostral-caudal gradient predominantly connecting the frontopolar and ventral prefrontal cortices with the rostral ZI, and the primary sensorimotor cortices with the caudal ZI. Moreover, we demonstrate how clustering and gradient approaches build complementary evidence including facilitating the mapping of a central region of the ZI, connected with the dorsal prefrontal cortex. These results were shown to be replicable across multiple datasets and at the individual subject level, building evidence for the important role of the ZI in mediating frontal lobe-associated tasks, ranging from motor to cognitive to emotional control. Finally, we consider the impact of this topographic organization on the refinement of neuromodulatory targets. These results pave the way for an increasingly detailed understanding of ZI substructures, and considerations forin vivotargeting of the ZI for neuromodulation.

show abstract

Mapping the topographic organization of the human zona incerta using diffusion MRI

Haast,

Kai,

Taha

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Dual target deep brain stimulation for complex essential and dystonic tremor – A 5-year follow up

Cited by 1 publication

References 22 publications

Mapping the topographic organization of the human zona incerta using diffusion MRI

Mapping the topographic organization of the human zona incerta using diffusion MRI

Contact Info

Product

Resources

About