Duffy blood group system and ocular toxoplasmosis

Ferreira, Ana Iara Costa; Mattos, Cinara Cássia Brandão de; Frederico, Fábio Batista; Bernardo, Cássia Rubia; Almeida, G. C.; Siqueira, Rubens Camargo; Meira-Strejevitch, Cristina da Silva; Pereira-Chioccola, Vera Lúcia; Mattos, Luiz Carlos de

doi:10.1016/j.meegid.2020.104430

Cited by 2 publications

(3 citation statements)

References 58 publications

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“…Blood group systems other than the ABO system have been assessed on their association with T. gondii infection. In a recent study, researchers assessed the association between T. gondii infection and the Duffy blood group system and found that phenotypes and antigens of this blood group system do not constitute risk factors for infection by T. gondii and the development of ocular toxoplasmosis [ 27 ]. In a study of pregnant women in Brazil, investigators showed that the Lewis b profile appears to protect against T. gondii infection [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Association between ABO and Rh blood groups and Toxoplasma gondii infection: A cross sectional study

Pérez-Álamos,

Aguilar-Durán,

Estrada Martínez

et al. 2024

EuJMI

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We aimed to determine the association between the seropositivity to Toxoplasma gondii and the ABO and Rh blood groups in 2,053 people. ABO and Rhesus blood groups and anti-T. gondii IgG and IgM antibodies were determined using commercially available assays. Of the 2,053 people studied, 171 (8.3%) were positive for anti-T. gondii IgG antibodies. Sixty-five (38.0%) and 36 (21.1%) of these 171 individuals had high anti-T. gondii IgG antibody levels (≥150 IU mL−1) and anti-T. gondii IgM antibodies, respectively. We found the following prevalences of T. gondii infection among the ABO groups: 8.5% in group A, 4.3% in group B, 4.7% in group AB, and 8.9% in group O (P = 0.19). The prevalences of T. gondii infection among Rh groups were: 8.4% in the Rh-positive group and 7.1% in the Rh-negative group (P = 0.58). Logistic regression analysis showed that the frequencies of ABO and Rh blood groups were similar (P > 0.05) among people with positive and negative serology for anti-T. gondii IgG antibodies, with high (≥150 IU mL−1) and lower (<150 IU mL−1) levels of anti-T. gondii IgG antibodies, and with positive and negative serology for anti-T. gondii IgM antibodies. Results does not support an association between T. gondii infection and ABO and Rh blood groups.

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Section: Discussionmentioning

confidence: 99%

Association between ABO and Rh blood groups and Toxoplasma gondii infection: A cross sectional study

Pérez-Álamos,

Aguilar-Durán,

Estrada Martínez

et al. 2024

EuJMI

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“…The Duffy blood group system is a clinically remarkable blood group system 1 . It comprises six antigens (Fy a , Fy b , Fy 3 , Fy 4 , Fy 5 , Fy 6 ), and four main phenotypes; Fy(a+b+), Fy(a−b+), Fy(a+b−), and Fy(a−b−) 2,3 . The antigens are expressed on a glycosylated erythrocyte membrane protein known as the Duffy antigen receptor for chemokines (DARC).…”

Section: Introductionmentioning

confidence: 99%

“… 1 It comprises six antigens (Fy a , Fy b , Fy 3 , Fy 4 , Fy 5 , Fy 6 ), and four main phenotypes; Fy(a+b+), Fy(a−b+), Fy(a+b−), and Fy(a−b−). 2 , 3 The antigens are expressed on a glycosylated erythrocyte membrane protein known as the Duffy antigen receptor for chemokines (DARC). The absence of DARC on the red blood cell surface is correlated with various conditions such as inflammation, human immunodeficiency virus infection, and malignancies.…”

Section: Introductionmentioning

confidence: 99%

The highest Duffy (FYX) allele frequency ever reported for Scottish population: A cross‐sectional study

Armstrong‐Fisher,

Urbaniak,

Karimi Rouzbahani

et al. 2023

Health Science Reports

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Background and Aim The Duffy (FY) blood group system has six known antigens among which the Fya and Fyb are known as major antigens. Fyx phenotype forms as a result of two point mutations in the FYB allele leading to instability of Duffy protein and so reduction of Duffy antigen expression in the cells. This study aimed to investigate the FYX allele frequency in the Scottish population. Methods The Duffy blood group system was serologically and molecularly investigated in 222 samples collected from donors of Aberdeen Regional Blood Transfusion Center (BTC). The haemagglutination and BeadChip microarray chemistry methods were used for phenotyping and genotyping. Confirmatory tests were also used to check the discrepant results. Results In this study, the frequency of Duffy blood group phenotypes including Fya+, Fya+b+, and Fyb+ were 17.57%, 42.79%, and 39.64%, respectively. Furthermore, the frequency of FYA/FYA, FYA/FYB, and FYB/FYB genotypes was estimated to be 14.41%, 45.95%, and 39.64%, respectively, using the Bioarray method. In the present study, based on Duffy DNA sequencing results, 12 samples (5.41%) had just one FYX allele. Conclusion The frequency of the FYX allele in this study was estimated to be 0.0270% which is more than the results reported so far.

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Duffy blood group system and ocular toxoplasmosis

Cited by 2 publications

References 58 publications

Association between ABO and Rh blood groups and Toxoplasma gondii infection: A cross sectional study

Association between ABO and Rh blood groups and Toxoplasma gondii infection: A cross sectional study

The highest Duffy (FYX) allele frequency ever reported for Scottish population: A cross‐sectional study

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